Interleukin-15 Receptor α Chain Knockout NOD-SCID mice have reduced numbers of NK cells, develop thymic lymphomas and fail to engraft human hematopoietic cells

Autor: Wiles Mv, Ding L, Serreze D, Li H, Megan Sykes, Chavez E, Nauman G, Benjamin E. Low, Vecchione A, Marharlooei Mk, Danzl N

NOD-SCID IL2rγcnull (NSG) mice are widely used to model human immune cell development because they are more permissive for human hematopoietic cell engraftment and reconstitution than NOD-SCID mice. While increased human reconstitution in the blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9299b537a34e0d39bd55d402243a0973
https://doi.org/10.1101/2021.04.22.440980

Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs.

Autor: Nauman G; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Danzl NM; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Lee J; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Borsotti C; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Madley R; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Fu J; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Hölzl MA; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Dahmani A; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Dorronsoro Gonzalez A; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Chavez É; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Campbell SR; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Yang S; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Satwani P; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Department of Pediatrics, Columbia University Medical Center, Columbia University, New York, NY., Liu K; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Department of Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT; and., Sykes M; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, NY; megan.sykes@columbia.edu.; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, NY.; Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Department of Surgery, Columbia University Medical Center, Columbia University, New York, NY.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Apr 01; Vol. 208 (7), pp. 1652-1663. Date of Electronic Publication: 2022 Mar 21.

Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus.

Autor: Madley R; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.; Columbia University Department of Microbiology and Immunology, New York, NY, 10032, USA., Nauman G; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.; Columbia University Department of Microbiology and Immunology, New York, NY, 10032, USA., Danzl N; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA., Borsotti C; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA., Khosravi Maharlooei M; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA., Li HW; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA., Chavez E; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA., Creusot RJ; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA., Nakayama M; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Roep B; Department of Immunohaematology & Blood Transfusion, Leiden University Medical Center, 2300 RC, Leiden, the Netherlands.; Department of Diabetes Immunology, Diabetes & Metabolism Research Institute at the Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA., Sykes M; Columbia Center for Translational Immunology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.; Columbia University Department of Microbiology and Immunology, New York, NY, 10032, USA.; Columbia University Department of Surgery, New York, NY, 10032, USA.

Publikováno v: Journal of translational autoimmunity [J Transl Autoimmun] 2020 Aug 09; Vol. 3, pp. 100061. Date of Electronic Publication: 2020 Aug 09 (Print Publication: 2020).

Humanized immune system mouse model and its application in tumor immunotherapy.

Autor: WANG Chenkun¹, LIU Haofei^1,2 hfliu2023@sinano.ac.cn

Publikováno v: Chinese Journal of Immunology. Oct2024, Vol. 40 Issue 10, p2017-2030. 14p.

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.

Autor: Khosravi-Maharlooei M; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Obradovic A; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Misra A; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Motwani K; Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA., Holzl M; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Seay HR; Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA., DeWolf S; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Nauman G; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, New York, USA., Danzl N; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Li H; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Ho SH; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA., Winchester R; Division of Rheumatology, Department of Medicine., Shen Y; Center for Computational Biology and Bioinformatics, and., Brusko TM; Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA., Sykes M; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, New York, USA.; Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2019 Mar 28; Vol. 129 (6), pp. 2446-2462. Date of Electronic Publication: 2019 Mar 28.