Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Natsumi Takeyama"'
Autor:
Yoshikazu Yuki, Shiho Kurokawa, Kotomi Sugiura, Koji Kashima, Shinichi Maruyama, Tomoyuki Yamanoue, Ayaka Honma, Mio Mejima, Natsumi Takeyama, Masaharu Kuroda, Hiroko Kozuka-Hata, Masaaki Oyama, Takehiro Masumura, Rika Nakahashi-Ouchida, Kohtaro Fujihashi, Takashi Hiraizumi, Eiji Goto, Hiroshi Kiyono
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
We previously established the selection-marker-free rice-based oral cholera vaccine (MucoRice-CTB) line 51A for human use by Agrobacterium-mediated co-transformation and conducted a double-blind, randomized, placebo-controlled phase I trial in Japan
Externí odkaz:
https://doaj.org/article/7b4a2074dd93404f8d74acfa66ff2b73
Autor:
Natsumi Takeyama, Yoshikazu Yuki, Tatsuya Miyoshi, Lennart Hammarström, Akio Suzuki, Shintaro Sato, Hiroshi Kiyono, Yuki Goda, Naomi Matsumoto, Shiho Kurokawa, Naomi Sakon, Tomoyuki Tanaka, Harold Marcotte, Ai Sasou
Publikováno v:
The Journal of infectious diseases. 222(3)
Human noroviruses cause an estimated 685 million infections and 200 000 deaths annually worldwide. Although vaccines against GII.4 and GI.1 genotypes are under development, no information is available regarding vaccines or monoclonal antibodies to ot
Publikováno v:
Therapeutic Advances in Vaccines. 3:139-154
It has been about 30 years since the first plant engineering technology was established. Although the concept of plant-based pharmaceuticals or vaccines motivates us to develop practicable commercial products using plant engineering, there are some d
Publikováno v:
The Journal of Veterinary Medical Science
Elucidation of the processes regulating the prion protein gene (Prnp) is an important key to understanding the development of prion disorders. In this study, we explored the involvement of DNA methylation in Prnp transcriptional regulation during neu
Autor:
Natsumi Takeyama, Yoshikazu Yuki, Koji Kashima, Hiroshi Kiyono, Masaharu Kuroda, Yoshiko Fukuyama, Mio Mejima, Kimiko Itoh, Toshiaki Mitsui, Shiho Kurokawa
Publikováno v:
Plant Cell, Tissue and Organ Culture (PCTOC). 120:35-48
We previously developed a molecularly uniform rice-based oral cholera vaccine (MucoRice-CTB) by using an overexpression system for modified cholera toxin B-subunit, CTB (N4Q) with RNAi to suppress production of the major rice endogenous storage prote
Autor:
Masaharu Kuroda, Natsumi Takeyama, Yuko Takahashi, Yoshikazu Yuki, Mio Mejima, Shigeru Satoh, Hiroshi Kiyono, Takehiro Masumura, Rika Nakamura, Reiko Teshima, Shiho Kurokawa, Hiroshi Sagara
Publikováno v:
Plant Cell Reports. 33:75-87
RNAi-mediated suppression of the endogenous storage proteins in MucoRice-CTB-RNAi seeds affects not only the levels of overexpressed CTB and RAG2 allergen, but also the localization of CTB and RAG2. A purification-free rice-based oral cholera vaccine
Publikováno v:
The Journal of Veterinary Medical Science
The cellular isoform of the prion protein (PrPC) plays critical roles in the development of prion disorders. Although PrP mRNA is ubiquitously present in a tissue-specific manner, the DNA methylation of PrP gene (Prnp) is still unknown. In this study
Autor:
Masaharu Kuroda, Yoshiko Fukuyama, Yuji Suzuki, Shiho Kurokawa, Natsumi Takeyama, Yasuyuki Gomi, Yoshikazu Yuki, Tatsuhiko Azegami, Koji Kashima, Minoru Tamura, Mio Mejima, Hiroshi Kiyono, Takeshi Tanimoto, Satomi Minakawa
Publikováno v:
Plant cell reports. 35(3)
The first Good Manufacturing Practices production of a purification-free rice-based oral cholera vaccine (MucoRice-CTB) from transgenic plants in a closed cultivation system yielded a product meeting regulatory requirements. Despite our knowledge of
Autor:
Ayako Miyazaki, Natsumi Takeyama, Fumihiro Taguchi, Makoto Ujike, Kazuya Shirato, Madoka Maejima, Hidetoshi Ikeda, Shutoku Matsuyama
Publikováno v:
Virus Research
Murine-adapted porcine epidemic diarrhea virus (PEDV), MK-p10, shows high neurovirulence and increased fusion activity compared with a non-adapted MK strain. MK-p10 S protein had four mutations relative to the original virus S, and one of these (H
Autor:
Natsumi Takeyama, Tetsuo Sato, Ko-ichi Kusanagi, Kotaro Tuchiya, Atsushi Katsumata, Toshiaki Kodama
Publikováno v:
Virus Genes
Previously, we have reported that a serial passage of 83P-5 strain of porcine epidemic diarrhea virus (PEDV) in Vero cells resulted in a growth adaptation of the virus in cultured cells at the 22nd passage. In this study, we further maintained the 83