Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Natsuko Tanimura"'
Autor:
Shin-Ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, Natsuko Tanimura, Yoshiko Mori Saitoh, Ryutaro Fukui, Takuma Shibata, Katsuaki Sato, Takeshi Ichinohe, Mayumi Hayashi, Kazuishi Kubota, Hiroko Kozuka-Hata, Masaaki Oyama, Yorifumi Kikko, Toshiaki Katada, Kenji Kontani, Kensuke Miyake
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7+ endosomes to the periphery of the
Externí odkaz:
https://doaj.org/article/f3a96501c2b548c493e42bf4711580c2
Autor:
Ryutaro Fukui, Chikako Yamamoto, Fumi Matsumoto, Masahiro Onji, Takuma Shibata, Yusuke Murakami, Atsuo Kanno, Takuto Hayashi, Natsuko Tanimura, Nobuaki Yoshida, Kensuke Miyake
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mouse toll-like receptor 9 (TLR9) is an endosomal sensor for single-stranded DNA. TLR9 is transported from the endoplasmic reticulum to endolysosomes by a multiple transmembrane protein Unc93 homolog B1, and proteolytically cleaved at its ectodomain.
Externí odkaz:
https://doaj.org/article/098608ff306f4bcd8e80e8f7fd73df85
Autor:
Mayumi Hayashi, Kensuke Miyake, Toshiaki Katada, Shin-ichiroh Saitoh, Atsuo Kanno, Kazuishi Kubota, Fumiko Abe, Ryutaro Fukui, Natsuko Tanimura, Katsuaki Sato, Yorifumi Kikko, Hiroko Kozuka-Hata, Masaaki Oyama, Yoshiko Mori Saitoh, Takeshi Ichinohe, Kenji Kontani, Takuma Shibata
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Plasmacytoid dendritic cells (pDC) sense viral RNA through toll-like receptor 7 (TLR7), form self-adhesive pDC–pDC clusters, and produce type I interferons. This cell adhesion enhances type I interferon production, but little is known about the und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d908c0fd3e4b04c8923aebbc570dc6
https://doaj.org/article/f3a96501c2b548c493e42bf4711580c2
https://doaj.org/article/f3a96501c2b548c493e42bf4711580c2
Autor:
Toshiyuki Shimizu, Akinori Saeki, Shigeto Fujishita, Takahito Kimura, Hiroe Honda, Tatsuhisa Kato, Kensuke Miyake, Tomomi Yamaguchi-Miyamoto, Natsuko Tanimura, Naoki Okamoto, Ryutaro Fukui, Yoshinori Nagai, Yuji Motoi, B. Umeharu Ohto, Yukari Fujimoto, Koichi Fukase, Kiyoshi Takatsu, Takatsugu Hirokawa, Keisuke Mizote, Yasuharu Watanabe, Sachiko Akashi-Takamura
Publikováno v:
Journal of Biological Chemistry. 292:15378-15394
The Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) complex is essential for LPS recognition and induces innate immune responses against Gram-negative bacteria. As activation of TLR4/MD-2 is also critical for the induction of adap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0dd413b66699b06be53da59e5fd92c
https://doi.org/10.1074/jbc.m117.791780
https://doi.org/10.1074/jbc.m117.791780
Autor:
Eiji Umemoto, Yasushi Sakata, Yasushi Okamura, Yoshifumi Okochi, Mari Murakami, Kensuke Miyake, Tomohito Ohtani, Kiyoshi Takeda, Hidetaka Kioka, Taiki Sakaguchi, Yoshihiro Baba, Chisato Ono, Takafumi Kawai, Hisako Kayama, Ryu Okumura, Natsuko Tanimura, Daisuke Okuzaki
Publikováno v:
Cell reports. 31(10)
Summary B cells produce high amounts of cytokines and immunoglobulins in response to lipopolysaccharide (LPS) stimulation. Calcium signaling cascades are critically involved in cytokine production of T cells, and the cytosolic calcium concentration i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5501de19cee3033c4df59e8d7dbda23
https://pubmed.ncbi.nlm.nih.gov/32521253
https://pubmed.ncbi.nlm.nih.gov/32521253
Autor:
Ryutaro Fukui, Takuma Shibata, Shin-ichiroh Saitoh, Xiaobing Li, Kensuke Miyake, Natsuko Tanimura
Publikováno v:
International Immunology. 27:83-94
Toll-like receptor 7 (TLR7) and TLR9 sense microbial single-stranded RNA (ssRNA) and ssDNA in endolysosomes. Nucleic acid (NA)-sensing in endolysosomes is thought to be important for avoiding TLR7/9 responses to self-derived NAs. Aberrant self-derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d50eec856f0ea8badb696f9e26ea931
https://doi.org/10.1093/intimm/dxu086
https://doi.org/10.1093/intimm/dxu086
Autor:
Umeharu Ohto, Tsutomu Omori, Kensuke Miyake, Sachiko Akashi-Takamura, Akiko Komatsu, Natsuko Tanimura, Takeshi Tomita, Atsuko Deguchi, Yoshiro Maru, Satoshi Takahashi
Publikováno v:
The Journal of Immunology. 191:1856-1864
Serum amyloid A (SAA) 3 is a major component of the acute phase of inflammation. We previously reported that SAA3 served as an endogenous peptide ligand for TLR4 to facilitate lung metastasis. Because these experiments were performed with SAA3 recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7accfeea3f27242cfdcc3d67b7c1de
https://doi.org/10.4049/jimmunol.1201996
https://doi.org/10.4049/jimmunol.1201996
Autor:
Toshiyuki Shimizu, Koichiro Takahashi, Kensuke Miyake, Sachiko Akashi-Takamura, Yoshihiro Ogawa, Shin-ichiroh Saitoh, Takayoshi Suganami, Umeharu Ohto, Natsuko Tanimura, Takuma Shibata, Natsuko Yamakawa
Publikováno v:
International Immunology. 25:45-52
A cell surface heterodimer Toll-like receptor 4 (TLR4)/MD-2 senses lipopolysaccharide (LPS), a principal membrane component of Gram-negative bacteria. LPS binds to MD-2 and induces dimerization of TLR4/MD-2. Dimerized TLR4 activates downstream signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4220d3efd1d6fc08aa5517cec2d1d4b0
https://doi.org/10.1093/intimm/dxs084
https://doi.org/10.1093/intimm/dxs084
Autor:
Atsushi Shimoyama, Kensuke Miyake, Yasuo Suda, Koichi Fukase, Yukari Fujimoto, Natsuko Tanimura, Hiroko Tsutsui, Akinori Saeki
Publikováno v:
Chemistry - A European Journal. 17:14464-14474
Helicobacter pylori is a common cause of gastroduodenal inflammatory diseases such as chronic gastritis and peptic ulcers and also an important factor in gastric carcinogenesis. Recent reports have demonstrated that bacterial inflammatory processes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c72f8c6e449b4691dbf2547d0101dbe
https://doi.org/10.1002/chem.201003581
https://doi.org/10.1002/chem.201003581
Autor:
Yuji Motoi, Natsuko Tanimura, Sachiko Akashi-Takamura, Kensuke Miyake, Takuma Shibata, Natsuko Yamakawa
Publikováno v:
International Immunology. 23:503-510
Toll-like receptor (TLR)4/MD-2, a sensor for LPS, delivers the MyD88-dependent signal from the cell surface, then traffics to endolysosomes and delivers the TRIF/TICAM-1-dependent signal. Both signals are thought to be dependent on cell surface TLR4/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d67eb7d707d07014ed015b7217d9348
https://doi.org/10.1093/intimm/dxr044
https://doi.org/10.1093/intimm/dxr044