Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Natsuko Ohtomo"'
Autor:
Hitoshi Ikeda, Naoko Watanabe, Isao Ishii, Tatsuo Shimosawa, Yukio Kume, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Satoko Iitsuka, Ryoto Fujita, Masao Omata, Jerold Chun, Yutaka Yatomi
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 556-564 (2009)
Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in
Externí odkaz:
https://doaj.org/article/1a539debaaed4296be41e6af557fa349
Autor:
Yukiko Inoue, Tomoaki Tomiya, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Hitoshi Ikeda, Kazuhiko Koike
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78346 (2013)
BACKGROUND: Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, enhances hepatocyte function without stimulating proliferation, depending on the physiological conditions. p53, a transcription factor, suppresses the cell proliferation by
Externí odkaz:
https://doaj.org/article/a51f99e01a6c4589a100e921ba69c8be
Autor:
Baasanjav Uranbileg, Seiko Shinzawa, Kyoji Moriya, Kenichiro Enooku, Kazuhiko Koike, Hayato Nakagawa, Takako Nishikawa, Ryunosuke Ohkawa, Soichi Kojima, Yotaro Kudo, Tomokazu Matsuura, Hitoshi Ikeda, Haruhiko Yoshida, Yukiko Inoue, Natsuko Ohtomo, Yoko Soroida, Tomoaki Tomiya, Yutaka Yatomi, Ryosuke Tateishi
Publikováno v:
International Journal of Cancer. 134:2189-2198
We previously reported the increased serum mitochondrial creatine kinase (MtCK) activity in patients with hepatocellular carcinoma (HCC), mostly due to the increase in ubiquitous MtCK (uMtCK), and high uMtCK mRNA expression in HCC cell lines. We expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d547017964087d10322150e79fb4e1d
https://doi.org/10.1002/ijc.28547
https://doi.org/10.1002/ijc.28547
Autor:
Hiroshi Sakane, Tomoaki Tomiya, Yukimi Horii, Satoru Nogami, Natsuko Ohtomo, Hiromichi Shirataki
Publikováno v:
Histochemistry and Cell Biology. 141:165-180
α-Taxilin, a binding partner of the syntaxin family, is a candidate tumor marker. To gain insight into the physiological role of α-taxilin in normal tissues, we examined α-taxilin expression by Western blot and performed immunochemical analysis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baef1c9a1155ca206a2606513b2befca
https://doi.org/10.1007/s00418-013-1147-0
https://doi.org/10.1007/s00418-013-1147-0
Autor:
Tomoaki Tomiya, Yutaka Yatomi, Natsuko Ohtomo, Naoko Watanabe, Kazuaki Tejima, Yukio Kume, Chihiro Arai, Kenji Fujiwara, Masahiro Arai, Hitoshi Ikeda, Masao Omata, Takako Nishikawa
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G911-G917
A protective effect of Rho-kinase inhibitor on various organ injuries is gaining attention. Regarding liver injury, Rho-kinase inhibitor is reported to prevent carbon tetrachloride (CCl4)- or dimethylnitrosamine-induced liver fibrosis and hepatic isc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903966a66bc1098cf16d30d2d2dd1cb7
https://doi.org/10.1152/ajpgi.00210.2007
https://doi.org/10.1152/ajpgi.00210.2007
Autor:
Hitoshi Ikeda, Yasushi Tanoue, Takako Nishikawa, Kazuhiko Koike, Tomoaki Tomiya, Natsuko Ohtomo, Yukiko Inoue
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e78346 (2013)
PLoS ONE, Vol 8, Iss 11, p e78346 (2013)
Background Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, enhances hepatocyte function without stimulating proliferation, depending on the physiological conditions. p53, a transcription factor, suppresses the cell proliferation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0f2e4cd8bcd6377450614441ad5d1c
http://europepmc.org/articles/PMC3817248
http://europepmc.org/articles/PMC3817248
Autor:
Satoru Nogami, Takako Kaneko-Kawano, Yoji Kawano, Natsuko Ohtomo, Yukimi Horii, Tomoaki Tomiya, Hiromichi Shirataki
Publikováno v:
Cell structure and function. 37(2)
Intracellular vesicle traffic plays an essential role in the establishment and maintenance of organelle identity and biosynthetic transport. We have identified α-taxilin as a binding partner of the syntaxin family, which is involved in intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25af4594152eb9db6f18b438fb985792
https://pubmed.ncbi.nlm.nih.gov/22785156
https://pubmed.ncbi.nlm.nih.gov/22785156
Autor:
Baasanjav, Uranbileg, Kenichiro, Enooku, Yoko, Soroida, Ryunosuke, Ohkawa, Yotaro, Kudo, Hayato, Nakagawa, Ryosuke, Tateishi, Haruhiko, Yoshida, Seiko, Shinzawa, Kyoji, Moriya, Natsuko, Ohtomo, Takako, Nishikawa, Yukiko, Inoue, Tomoaki, Tomiya, Soichi, Kojima, Tomokazu, Matsuura, Kazuhiko, Koike, Yutaka, Yatomi, Hitoshi, Ikeda
Publikováno v:
International journal of cancer. 134(9)
We previously reported the increased serum mitochondrial creatine kinase (MtCK) activity in patients with hepatocellular carcinoma (HCC), mostly due to the increase in ubiquitous MtCK (uMtCK), and high uMtCK mRNA expression in HCC cell lines. We expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e42aff0ff94e0cf4701a0733c1c4dea
https://pubmed.ncbi.nlm.nih.gov/24174293
https://pubmed.ncbi.nlm.nih.gov/24174293
Autor:
Kazuhiko Koike, Hiromitsu Yokota, Yoshika Kusumoto, Takako Nishikawa, Mitsuru Yashiro, Naoko Watanabe, Yoh Takuwa, Takatoshi Koyama, Tomoaki Tomiya, Yuko Kageyama, Tatsuo Shimosawa, Yukiko Inoue, Masakazu Nagamine, Kazuhiro Ishimaru, Natsuko Ohtomo, Yasuo Okamoto, Hitoshi Ikeda, Yasushi Tanoue, Yutaka Yatomi, Yumiko Satoh, Koji Shinozaki
Publikováno v:
Hepatology (Baltimore, Md.). 56(4)
Sinusoidal vasoconstriction, in which hepatic stellate cells operate as contractile machinery, has been suggested to play a pivotal role in the pathophysiology of portal hypertension. We investigated whether sphingosine 1-phosphate (S1P) stimulates c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e348828f3b948df807cbc835bedc341
https://pubmed.ncbi.nlm.nih.gov/22505286
https://pubmed.ncbi.nlm.nih.gov/22505286
Autor:
Kazuhiko Koike, Tadashi Goto, Hitoshi Ikeda, Yasushi Tanoue, Hayato Nakagawa, Tomoaki Tomiya, Natsuko Ohtomo, Yukiko Inoue, Haruhiko Yoshida, Shuichiro Shiina, Yuji Kondo, Tomoko Ono, Ryota Masuzaki, Yutaka Yatomi, Ryosuke Tateishi, Yukio Kume, Kenichiro Enooku, Takako Nishikawa
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(10)
Background: Chronic liver injury evokes a wound healing response, promoting fibrosis and finally hepatocellular carcinoma (HCC), in which hepatic stellate cells play an important role. Although a blood marker of hepatic stellate cells is not known, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c8349ad651b5395ff0538c2d33e8ba
https://pubmed.ncbi.nlm.nih.gov/21876190
https://pubmed.ncbi.nlm.nih.gov/21876190