Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.

Autor: Homan CC; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Drazer MW; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Yu K; Division of Intramural Research, Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Lawrence DM; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia., Feng J; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia., Arriola-Martinez L; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Pozsgai MJ; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., McNeely KE; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Ha T; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Venugopal P; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Arts P; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., King-Smith SL; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Cheah J; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Armstrong M; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Wang P; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia., Bödör C; HCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Cantor AB; Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Cazzola M; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Degelman E; Alberta Children's Hospital, Calgary, Alberta, Canada., DiNardo CD; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Duployez N; Laboratory of Hematology, Biology and Pathology Center, Centre Hospitalier Regional Universitaire de Lille, Lille, France.; Jean-Pierre Aubert Research Center, INSERM, Universitaire de Lille, Lille, France., Favier R; Assistance Publique-Hôpitaux de Paris, Armand Trousseau Children's Hospital, Paris, France., Fröhling S; Department of Translational Medical Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Rio-Machin A; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Klco JM; St Jude Children's Research Hospital, Memphis, TN., Krämer A; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany., Kurokawa M; Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Lee J; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore., Malcovati L; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Morgan NV; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Natsoulis G; Imago Biosciences, Inc, San Francisco, CA., Owen C; Division of Hematology and Hematological Malignancies, Foothills Medical Centre, Calgary, AB, Canada., Patel KP; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Preudhomme C; Laboratory of Hematology, Biology and Pathology Center, Centre Hospitalier Regional Universitaire de Lille, Lille, France.; Jean-Pierre Aubert Research Center, INSERM, Universitaire de Lille, Lille, France., Raslova H; Institut Gustave Roussy, Université Paris Sud, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villejuif, France., Rienhoff H; Imago Biosciences, Inc, San Francisco, CA., Ripperger T; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Schulte R; Division of Pediatric Hematology and Oncology, Riley Children's Hospital, Indiana University School of Medicine, Indianapolis, IN., Tawana K; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom., Velloso E; Service of Hematology, Transfusion and Cell Therapy and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31) HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.; Genetics Laboratory, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Yan B; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore., Kim E; National Cancer Institute, National Institutes of Health, Rockville, MD., Sood R; Division of Intramural Research, Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Hsu AP; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Holland SM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Phillips K; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Poplawski NK; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia., Babic M; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Wei AH; Department of Haematology, Peter McCallum Cancer Centre, Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research, The University of Melbourne, Melbourne, VIC, Australia., Forsyth C; Central Coast Haematology, North Gosford, NSW, Australia., Mar Fan H; Department of Medicine, The University of Queensland, Brisbane, QLD, Australia., Lewis ID; Adelaide Oncology & Haematology, North Adelaide, SA, Australia., Cooney J; Department of Haematology, Fiona Stanley Hospital, Murdoch, WA, Australia., Susman R; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Fox LC; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Blombery P; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Singhal D; Department of Haematology, SA Pathology, Adelaide, SA, Australia., Hiwase D; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.; Department of Haematology, SA Pathology, Adelaide, SA, Australia., Phipson B; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Paediatrics and Department of Molecular Biology, The University of Melbourne, Melbourne, VIC, Australia., Schreiber AW; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia.; School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia., Hahn CN; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia., Scott HS; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia., Liu P; Division of Intramural Research, Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Godley LA; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Brown AL; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.

Publikováno v: Blood advances [Blood Adv] 2023 Oct 24; Vol. 7 (20), pp. 6092-6107.

DC algorithm for estimation of sparse Gaussian graphical models.

Autor: Shiratori, Tomokaze¹ (AUTHOR) cygnus.2xl@gmail.com, Takano, Yuichi² (AUTHOR)

Publikováno v: PLoS ONE. 12/23/2024, Vol. 19 Issue 12, p1-23. 23p.

RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.

Autor: Brown AL; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.; School of Medicine, University of Adelaide, Adelaide, SA, Australia., Arts P; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Carmichael CL; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia., Babic M; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Dobbins J; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Chong CE; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Schreiber AW; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.; Australian Cancer Research Foundation (ACRF) Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia., Feng J; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.; Australian Cancer Research Foundation (ACRF) Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia., Phillips K; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Wang PPS; Australian Cancer Research Foundation (ACRF) Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia., Ha T; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Homan CC; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., King-Smith SL; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Rawlings L; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Vakulin C; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Dubowsky A; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Burdett J; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Moore S; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., McKavanagh G; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Henry D; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Wells A; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Mercorella B; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Nicola M; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Suttle J; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia., Wilkins E; Department of Molecular Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Li XC; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Michaud J; Department of Molecular Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Brautigan P; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Cannon P; Department of Molecular Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Altree M; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Jaensch L; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Fine M; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Butcher C; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.; Department of Haematology, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia., D'Andrea RJ; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia., Lewis ID; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia.; Department of Haematology, SA Pathology, Adelaide, SA, Australia., Hiwase DK; School of Medicine, University of Adelaide, Adelaide, SA, Australia.; Department of Haematology, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia.; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Papaemmanuil E; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY., Horwitz MS; Department of Pathology, University of Washington, Seattle, WA., Natsoulis G; Imago Biosciences, Inc, San Francisco, CA., Rienhoff HY; Imago Biosciences, Inc, San Francisco, CA., Patton N; Department of Haematology, Auckland City Hospital, Auckland, New Zealand., Mapp S; Department of Haematology, Princess Alexandra Hospital, Brisbane, QLD, Australia., Susman R; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Morgan S; Department of Haematology, Alfred Hospital, Melbourne, VIC, Australia., Cooney J; Department of Haematology, Fiona Stanley Hospital, Murdoch, WA, Australia., Currie M; LewisGale Medical Center, Salem, VA., Popat U; The University of Texas MD Anderson Cancer Center, Houston, TX., Bochtler T; Clinical Cooperation Unit Molecular Hematology/Oncology, Department of Internal Medicine V, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany., Izraeli S; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Hemato-Oncology, Schneider Children's Medical Center, Petach Tiqva, Israel., Bradstock K; Haematology Department, Westmead Hospital, Westmead, NSW, Australia., Godley LA; Section of Hematology/Oncology, Department of Medicine and Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Krämer A; Clinical Cooperation Unit Molecular Hematology/Oncology, Department of Internal Medicine V, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany., Fröhling S; National Center for Tumor Diseases Heidelberg, German Cancer Research Center, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium, Heidelberg, Germany., Wei AH; The Alfred Hospital, Monash University, Melbourne, VIC, Australia., Forsyth C; Jarrett St Specialist Centre, North Gosford, NSW, Australia; and., Mar Fan H; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Poplawski NK; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.; Discipline of Paediatrics, Faculty of Health Sciences, School of Medicine, University of Adelaide, Adelaide, SA, Australia., Hahn CN; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.; School of Medicine, University of Adelaide, Adelaide, SA, Australia., Scott HS; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.; School of Medicine, University of Adelaide, Adelaide, SA, Australia.; Australian Cancer Research Foundation (ACRF) Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.

Publikováno v: Blood advances [Blood Adv] 2020 Mar 24; Vol. 4 (6), pp. 1131-1144.

Characterization of MAP c21873-1 as a new counter-selectable marker for unmarked genetic modification of Pichia pastoris.

Autor: Liu, Minzhi^1,2 (AUTHOR), Zhou, Sihan² (AUTHOR), Cao, Yunsong² (AUTHOR), Yang, Keqin² (AUTHOR), Xiao, Yao² (AUTHOR), Wang, Wei^1,2 (AUTHOR) wwang@imm.ac.cn

Publikováno v: Microbial Cell Factories. 8/8/2024, Vol. 23 Issue 1, p1-16. 16p.

Alternative TSS use is widespread in Cryptococcus fungi in response to environmental cues and regulated genome-wide by the transcription factor Tur1.

Autor: Dang, Thi Tuong Vi¹ (AUTHOR), Maufrais, Corinne² (AUTHOR), Colin, Jessie^1,3 (AUTHOR), Moyrand, Frédérique¹ (AUTHOR), Mouyna, Isabelle¹ (AUTHOR), COPPEE, Jean-Yves¹ (AUTHOR), Onyishi, Chinaemerem U.⁴ (AUTHOR), Lipecka, Joanna⁵ (AUTHOR), Guerrera, Ida Chiara⁵ (AUTHOR), May, Robin C.⁴ (AUTHOR), Janbon, Guilhem¹ (AUTHOR) Guilhem.Janbon@pasteur.fr

Publikováno v: PLoS Biology. 7/25/2024, Vol. 22 Issue 7, p1-35. 35p.