Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Natrajan Ramasubramanyan"'
Autor:
Kevin Wamiti Pfizer Global Res. Dev. Muthurania, Gopinath Vedachalam Annathur, Natrajan Ramasubramanyan, John J. Buckley
Publikováno v:
Journal of Chromatography A. 1217:3783-3793
A cation exchange chromatographic purification process step was developed for the purification of human PEGylated PYY 3-36 from the PEGylation reaction mixture. In this publication we describe experiments carried out to evaluate the chromatographic p
Autor:
Natrajan Ramasubramanyan, Paul Mensah, Mark E. Gustafson, Alan K. Hunter, Timothy M. Pabst, Giorgio Carta
Publikováno v:
Biotechnology Progress. 24:1096-1106
This work concerns the chromatographic separation of protein charge variants using pH gradients generated by step changes in buffer composition with weak base anion exchange columns. A local equilibrium model is first developed to describe pH transit