Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Natik I, Piriev"'
Autor:
A. Rapoport, Steven Nusinowitz, Natik I. Piriev, Muriel T. Davisson, John R. Heckenlively, Christine A. Kozak, Patsy M. Nishina, Norman L. Hawes, Debora B. Farber, Bo Chang, Michael Danciger, Thomas H. Roderick, N. B. Akhmedov
Publikováno v:
Proceedings of the National Academy of Sciences. 97:5551-5556
The rd7 mouse, an animal model for hereditary retinal degeneration, has some characteristics similar to human flecked retinal disorders. Here we report the identification of a deletion in a photoreceptor-specific nuclear receptor (mPNR) mRNA that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f08d1479a639e87bce37a4fd9424bb
https://doi.org/10.1073/pnas.97.10.5551
https://doi.org/10.1073/pnas.97.10.5551
Autor:
Samuel G. Jacobson, Xavier Guillonneau, Christine A. Kozak, Michael Danciger, Artur V. Cideciyan, Natik I. Piriev, Debora B. Farber
Publikováno v:
Human Molecular Genetics. 8:1541-1546
Retinitis pigmentosa (RP) represents a group of inherited human retinal diseases which involve degeneration of photoreceptor cells resulting in visual loss and often leading to blindness. In order to identify candidate genes for the causes of these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cab89cd96ef51c73020d1b230b016a1
https://doi.org/10.1093/hmg/8.8.1541
https://doi.org/10.1093/hmg/8.8.1541
Autor:
Michael Danciger, N. B. Akhmedov, Silvia N.M. Reid, Debora B. Farber, Christine A. Kozak, Natik I. Piriev
Publikováno v:
Gene. 227:257-266
Retinal photoreceptor cells are particularly vulnerable to degenerations that can eventually lead to blindness. Our purpose is to identify and characterize genes expressed specifically in photoreceptors in order to increase our understanding of the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5622f63478c68d560d8a10b6307b7d
https://doi.org/10.1016/s0378-1119(98)00578-2
https://doi.org/10.1016/s0378-1119(98)00578-2
Autor:
Gregory M. Acland, N. B. Akhmedov, Gustavo D. Aguirre, Natik I. Piriev, Debora B. Farber, Kunal Ray
Publikováno v:
Gene. 194:47-56
The cDNA for the beta3-subunit of cone-specific transducin (Tbeta3) was cloned and characterized from wild type dogs, and used in linkage studies as a candidate gene for cone degeneration. Sequence analysis of the Tbeta3 cDNA revealed an open reading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e0da30c713b68590450fe7c1f8e3ab
https://doi.org/10.1016/s0378-1119(97)00134-0
https://doi.org/10.1016/s0378-1119(97)00134-0
Autor:
Debora B. Farber, Julie R. Korenberg, Natik I. Piriev, Jingjing Ye, Andrea S. Viczian, Berit Kerner
Publikováno v:
Genomics. 28:429-435
The genomic organization and nucleotide structure of the human cone photoreceptor cGMP phosphodiesterase alpha'-subunit (alpha'-PDE) gene (PDEA2) as well as its chromosomal localization have been determined. This gene, which spans about 48 kb, consis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683b6a950bfa4a6cb13f1b6e9a266c4b
https://doi.org/10.1006/geno.1995.1171
https://doi.org/10.1006/geno.1995.1171
Publikováno v:
Molecular vision. 9
A functional protein is required for structure/function analysis of cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEalpha'). The purpose of this study was to express enzymatically active PDEalpha'.Three expression vectors were constructe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5a89801d6cf71d1ea565890d8d70483
https://pubmed.ncbi.nlm.nih.gov/12655284
https://pubmed.ncbi.nlm.nih.gov/12655284
Autor:
Natik I. Piriev, Debora B. Farber, Leonid E. Lerner, Yekaterina E. Gribanova, Barry E. Knox, Mark R. Verardo
Publikováno v:
New Insights Into Retinal Degenerative Diseases ISBN: 9781461355137
Mutations in the protein-coding region of the gene encoding the (β-subunit of cyclic GMP-phosphodiesterase (β-PDE) cosegregate with retinal degeneration affecting humans1, mice2,3 and dogs4,5. Moveover, given that the exonic sequences are intact, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11c76cccda104161cb86289256232344
https://doi.org/10.1007/978-1-4615-1355-1_28
https://doi.org/10.1007/978-1-4615-1355-1_28
Publikováno v:
Degenerative Retinal Diseases ISBN: 9781461377184
Studies on animal models of retinitis pigmentosa and allied retinal degenerations have provided very useful information about the molecular basis of these diseases. The genes identified as responsible for the primary cause of the disorders in animals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21cb53b66712c63090598f2913273f68
https://doi.org/10.1007/978-1-4615-5933-7_25
https://doi.org/10.1007/978-1-4615-5933-7_25
Autor:
Michael Danciger, Samuel G. Jacobson, Dan Yun Zhao, John Blaney, Natik I. Piriev, Jennifer Shih, John H. Heckenlively, Debora B. Farber, Yong Qing Gao
Publikováno v:
Experimental eye research. 62(2)
Each of the 22 exons and 140bp of the 5′ untranslated region of the gene encoding the β-subunit of cGMP-phosphodiesterase (PDE6B) were screened by denaturing gradient gel electrophoresis for mutations in the DNAs of 54 unrelated individuals with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db84652d306fd58d763201080b4a4c6
https://pubmed.ncbi.nlm.nih.gov/8698075
https://pubmed.ncbi.nlm.nih.gov/8698075
Publikováno v:
Gene. 166(2)
A human cDNA (alpha-PDE) encoding the alpha' catalytic subunit of cone photoreceptor cGMP-phosphodiesterase has been isolated and characterized. The nucleotide sequence of 2980 bp contains an open reading frame encoding an 859-amino-acid (aa) protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c047296d77a2b3488cca63db7f4cab4a
https://pubmed.ncbi.nlm.nih.gov/8543163
https://pubmed.ncbi.nlm.nih.gov/8543163