Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nathanyal J. Truax"'
Autor:
Ola El Atab, Rabih Darwiche, Nathanyal J. Truax, Roger Schneiter, Kenneth G. Hull, Daniel Romo, Oluwatoyin A. Asojo
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system. Small molecules found in E-S products of mammalian hookworms include nematode deri
Externí odkaz:
https://doaj.org/article/2486b41387b24a07b433cc5e979a4cdf
Publikováno v:
J Am Chem Soc
A pharmacophore-directed retrosynthetic (PDR) strategy was applied to the first total synthesis of the cembranoid, rameswaralide, in order to simultaneously achieve a total synthesis while also developing a structure-activity relationship profile thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5548e14c168ff45bcc7b32d6e04d103
https://doi.org/10.1021/jacs.2c08245
https://doi.org/10.1021/jacs.2c08245
Autor:
Nathanyal J. Truax, Daniel Romo
Publikováno v:
Nat Prod Rep
Covering: 1986 to 2020Natural products are an enduring source of chemical information useful for probing biologically relevant chemical space. Toward gathering further structure-activity relationship (SAR) information for a particular natural product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac6de4f0b74f73fbf0ea982859c30e3
https://doi.org/10.1039/d0np00048e
https://doi.org/10.1039/d0np00048e
Publikováno v:
Organic Letters. 21:7394-7399
A pharmacophore-directed retrosynthesis strategy applied to rameswaralide provided simplified precursors bearing the common 5,5,6 (red) and 5,5,7 (blue) skeleton present in several cembranoid and n...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53592beb8d766cb87717d31b4802b0f4
https://doi.org/10.1021/acs.orglett.9b02713
https://doi.org/10.1021/acs.orglett.9b02713
Autor:
Deborah O. Kwansare, Kaitlynn A. Sockett, Namita D. Neerukonda, Patricia Mowery, Erin T. Pelkey, Megan M. Lafferty, Nathan R. Webster, Marissa A. McFadden, Kelsey Pierce, Brianna Hurysz, Roslyn R. Patel, Nathanyal J. Truax, Madison M. Filkorn
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
Analogs of diarylpyrrolinone lead compound 1 were prepared and tested for anti-proliferative activity in U-937 cancer cells. Alterations of 1 focused on modifying the two nitrogen atoms: a) the pyrrolinone nitrogen atom was substituted with a propyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc9b6c5e1071b7a94a6b5b2fdfb1e9e
https://pubmed.ncbi.nlm.nih.gov/33775833
https://pubmed.ncbi.nlm.nih.gov/33775833
Publikováno v:
Organic letters. 21(18)
A Pharmacophore-Directed Retrosynthesis (PDR) strategy applied to rameswaralide provided simplified precursors bearing the common 5,5,6 (red) and 5,5,7 (blue) skeleton present in several cembranoid and norcembranoids from Sinularia soft corals. Key s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0190a9f83b44022fc9f7731c6846e38d
https://pubmed.ncbi.nlm.nih.gov/31498642
https://pubmed.ncbi.nlm.nih.gov/31498642
Autor:
Nathanyal J. Truax, Fernando Banales Mejia, Megan M. Lafferty, Erin T. Pelkey, Sophia J. Melvin, Maeve H. Kean
Publikováno v:
Synlett. 28:260-264
The electrophilic substitution of indoles with tetronic acid and N-acetyltetramic acid mediated by BF3·OEt2 was investigated. This strategy allowed for the preparation of nine indole-substituted furan-2-ones (indolyl-γ-lactones) and 3-pyrrolin-2-on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd35926da1d20245852d30a57a6baf8
https://doi.org/10.1055/s-0036-1588335
https://doi.org/10.1055/s-0036-1588335
Autor:
Deborah O. Kwansare, Maeve H. Kean, Fernando Banales Mejia, Erin T. Pelkey, Megan M. Lafferty, Nathanyal J. Truax
Publikováno v:
The Journal of Organic Chemistry. 81:6808-6815
A simple and flexible approach to 3-pyrrolin-2-one fused carbazoles is disclosed. The key step involves the BF3-mediated electrophilic substitution of indoles with N-alkyl-substituted 3-aryltetramic acids, which provides access to indole-substituted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4e24e6f84df878c9919479b112b471
https://doi.org/10.1021/acs.joc.6b01072
https://doi.org/10.1021/acs.joc.6b01072
Autor:
Namita D. Neerukonda, Megan M. Lafferty, Carly E. Rolph, Fernando Banales Mejia, Courtney L. Franceschi, Erin T. Pelkey, Deborah O. Kwansare, Patricia Mowery, Nathanyal J. Truax, Maeve H. Kean
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(2)
Analogs containing a central 3-pyrrolin-2-one core with different methoxyphenyl and/or indole substituents were prepared and tested for anti-proliferative activity in U-937 cells. The most efficacious analogs were non-rigid, (non-fused) contained met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90b6fda3135a3fc95225ee8e1ba2264
https://pubmed.ncbi.nlm.nih.gov/27916489
https://pubmed.ncbi.nlm.nih.gov/27916489