Výsledky vyhledávání - "Nathaniel Wisch"

Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders

Autor: John Mascarenhas, Nathaniel Wisch, Takefumi Ishii, Wei Zhang, Ying Dai, Mingjiang Xu, Jiapeng Wang, Ronald Hoffman

Publikováno v: Blood. 113:5942-5950

Pruritus is a common symptom in patients with Philadelphia chromosome–negative myeloproliferative disorders (MPDs). The pathophysiology of MPD-associated pruritus is unclear. We have demonstrated that MPD mast cells (MCs) are involved by the malign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7984002c0591423be729645a66d7b147
https://doi.org/10.1182/blood-2008-09-179416

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Development of t(8;21) and RUNX1-RUNX1T1 in the Philadelphia-positive clone of a patient with chronic myelogenous leukemia: additional evidence for multiple steps involved in disease progression

Autor: Ronald Hoffman, Leonard Issa, John Mascarenhas, Vesna Najfeld, Joseph Tripodi, Manpreet Sidhu, Nathaniel Wisch

Publikováno v: Cancer genetics. 204(3)

A 65-year-old patient with a high hemoglobin and hematocrit was treated for 14 months with therapeutic phlebotomy when cytogenetics of bone marrow revealed 100% cells with the Ph chromosome and 45% of the Ph+ cells contained trisomy 8. Treatment with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13973bfc5a40186e082348eed81af09
https://pubmed.ncbi.nlm.nih.gov/21504717

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Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms

Autor: Charles J. Parker, Ronald Hoffman, Judith D. Goldberg, Brenda Panzera, Josef T. Prchal, Nathaniel Wisch, John Mascarenhas, Steven Gruenstein, Mingjiang Xu, Amanda LeBlanc, Vesna Najfeld, Xiaoli Wang

Publikováno v: Experimental hematology. 37(10)

Objective JAK2V617F occurs in ∼93% of patients with polycythemia vera and ∼50% of patients with either primary myelofibrosis or essential thrombocythemia. Chromosomal abnormalities are detected in 50% of patients with primary myelofibrosis, 29% w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90749361ccd4610f6226a6bcb9bd3814
https://pubmed.ncbi.nlm.nih.gov/19615425

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Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms

Autor: John Mascarenhas, J Wang, W Zhang, Takefumi Ishii, Zhizhuang Joe Zhao, Selcuk Sozer, Robert S. Hoffman, Mingjiang Xu, Vesna Najfeld, Nathaniel Wisch, Y Dai

Publikováno v: Leukemia. 23(9)

The Philadelphia chromosome negative myeloproliferative neoplasms (MPNs) are clonal hematologic malignancies frequently characterized by a mutation in JAK2 (JAK2V617F). Peripheral blood (PB) CD34(+) cells from patients with polycythemia vera (PV) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0421892e1211aa0b570794584df6517b
https://pubmed.ncbi.nlm.nih.gov/19387466

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Chemotherapy of Metastatic Merkel Cell Cancer

Autor: Nathaniel Wisch, Martin Weiner, Lewis R. Silverman, John Crown, Roberto Lipzstein, Michael A. Goldsmith, James F. Holland, Ira Jaffrey, P. Alberto Paciucci, Larry Norton, Seymour Cohen

Publikováno v: Cancer Investigation. 9:129-132

Out of 16 cases of Merkel cell cancer identified in the records of the Mt. Sinai Medical Center or affiliates, 11 patients developed systemic metastases. Literature review confirms the substantial possibility of dissemination. Both in our series and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0670bb731ea3ebb6b7641f7813a68b
https://doi.org/10.3109/07357909109044222

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Malignant neoplasms subsequent to treatment of inflammatory bowel disease with 6-mercaptopurine

Autor: Jonathan I Warman, Mark R. Fleisher, Felice Mirsky, Burton I. Korelitz, Nathaniel Wisch, Gilbert W Gleim

Publikováno v: The American journal of gastroenterology. 94(11)

OBJECTIVE: Most complications of 6-mercaptopurine (6MP) used in the treatment of inflammatory bowel disease (IBD) occur early, whereas neoplasms occur late in the course. Concern persists that the risk is increased when 6MP is used. We report our exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c99cfecb5c484d2a8aec6c91ff0264a
https://pubmed.ncbi.nlm.nih.gov/10566724

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Hairy cell leukemia in association with thrombotic thrombocytopenic purpura and factor VIII antibodies

Autor: Judith Brody, Joel L. Moake, Nathaniel Wisch, Stuart M. Lichtman, Joel Moses

Publikováno v: Leukemialymphoma. 22(3-4)

A unique patient is reported with longstanding hairy cell leukemia who manifested two distinct abnormalities of factor VIII; factor VIII antibodies and recurrent thrombotic thrombocytopenic purpura (TTP). The patient presented in 1977 with splenomega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98593d5938916e12b30c0bb6bd298b48
https://pubmed.ncbi.nlm.nih.gov/8819086

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Spurious fibrinogen levels secondary to pyroglobulinemia in Waldenström's macroglobulinemia

Autor: Pablo J. Cagnoni, Jacob H. Rand, Nathaniel Wisch, Stephanie Seremetis, Renato Lenzi

Publikováno v: American journal of hematology. 48(2)

We report two cases of pyroglobulinemia detected in the course of routine determination of fibrinogen levels measured by the heat-precipitation method and that led to the diagnosis of Waldenstrom's macroglobulinemia. The incidence of pyroglobulinemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142f6056592a0204335c2151d39866b0
https://pubmed.ncbi.nlm.nih.gov/7847327

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