Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nathaniel T. Burkholder"'
Autor:
Adam H. Tencer, Jiuyang Liu, Jing Zhu, Nathaniel T. Burkholder, Yi Zhang, Wenwen Wu, Brian D. Strahl, Tomohiko Ohta, Tatiana G. Kutateladze
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2ZZ) recognizes a mimetic of the Nt-R cargo degradatio
Externí odkaz:
https://doaj.org/article/003cc22de27043328acd94df25cb60e4
Autor:
Simon d’Oelsnitz, Wantae Kim, Nathaniel T. Burkholder, Kamyab Javanmardi, Ross Thyer, Yan Zhang, Hal S. Alper, Andrew D. Ellington
Publikováno v:
Nature Chemical Biology. 18:981-989
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1b0e1cc2564763e2db5331c12e88bd
https://doi.org/10.1038/s41589-022-01072-w
https://doi.org/10.1038/s41589-022-01072-w
Autor:
Joshua E Mayfield, Seema Irani, Edwin E Escobar, Zhao Zhang, Nathaniel T Burkholder, Michelle R Robinson, M Rachel Mehaffey, Sarah N Sipe, Wanjie Yang, Nicholas A Prescott, Karan R Kathuria, Zhijie Liu, Jennifer S Brodbelt, Yan Zhang
Publikováno v:
eLife, Vol 8 (2019)
The Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of RNA polymerase II and is essential for the transition from transcription initiation to elongation in
Externí odkaz:
https://doaj.org/article/53e0122eb0c34ddbb874f06e2b7e518b
Autor:
John Blazeck, Christos S. Karamitros, Kyle Ford, Catrina Somody, Ahlam Qerqez, Kyle Murray, Nathaniel T. Burkholder, Nicholas Marshall, Anirudh Sivakumar, Wei-Cheng Lu, Bing Tan, Candice Lamb, Yuri Tanno, Menna Y. Siddiqui, Norah Ashoura, Silvia Coma, Xiaoyan M. Zhang, Karen McGovern, Yoichi Kumada, Yan Jessie Zhang, Mark Manfredi, Kenneth A. Johnson, Sheena D’Arcy, Everett Stone, George Georgiou
Publikováno v:
Nat Catal
The Trp metabolite kynurenine (KYN) accumulates in numerous solid tumours and mediates potent immunosuppression. Bacterial kynureninases (KYNases), which preferentially degrade kynurenine, can relieve immunosuppression in multiple cancer models, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0ac6472e6fbfd35f3de3a946823b38
https://europepmc.org/articles/PMC9717613/
https://europepmc.org/articles/PMC9717613/
Autor:
Simon, d'Oelsnitz, Wantae, Kim, Nathaniel T, Burkholder, Kamyab, Javanmardi, Ross, Thyer, Yan, Zhang, Hal S, Alper, Andrew D, Ellington
Publikováno v:
Nature chemical biology. 18(9)
A key bottleneck in the microbial production of therapeutic plant metabolites is identifying enzymes that can improve yield. The facile identification of genetically encoded biosensors can overcome this limitation and become part of a general method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00b64e0aaa729da3a4810329eda0a2a7
https://pubmed.ncbi.nlm.nih.gov/35799063
https://pubmed.ncbi.nlm.nih.gov/35799063
Autor:
Kamyab Javanmardi, Simon d'Oelsnitz, Ross Thyer, Nathaniel T. Burkholder, Hal S. Alper, Yan Zhang, Andrew D. Ellington, Wantae Kim
A key bottleneck in the microbial production of therapeutic plant metabolites is identifying enzymes that can greatly improve yield. The facile identification of genetically encoded biosensors can overcome this limitation and become part of a general
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f31da13cbb98b98b8acfb53cda49a3d
https://doi.org/10.1101/2021.06.07.447399
https://doi.org/10.1101/2021.06.07.447399
Autor:
Wendy L. Matthews, Seema Irani, Yuanchao Xue, Xiaohua Yu, Faqin Jiang, Daniel K. Arce, Yan Jessie Zhang, Joshua E. Mayfield, Nathaniel T. Burkholder
Publikováno v:
Journal of Biological Chemistry. 293:16851-16861
The RE1-silencing transcription factor (REST) is the major scaffold protein for assembly of neuronal gene silencing complexes that suppress gene transcription through regulating the surrounding chromatin structure. REST represses neuronal gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a18dc66beac6dea36e794ac1a72a3a
https://doi.org/10.1074/jbc.ra118.004722
https://doi.org/10.1074/jbc.ra118.004722
Autor:
Wendy M. Matthews, Sarah N. Sipe, Haoyi Wu, Edwin E. Escobar, Seema Irani, Jennifer S. Brodbelt, Wanjie Yang, Mukeshkumar Venkatramani, Yan Zhang, Nathaniel T. Burkholder
Publikováno v:
ACS Chem Biol
The C-terminal domain (CTD) of the largest subunit in eukaryotic RNA polymerase II has a repetitive heptad sequence of Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 which is responsible for recruiting transcriptional regulatory factors. The seventh heptad resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a16bb3734a9e57557a1278b7d0d592
https://doi.org/10.1021/acschembio.9b00610
https://doi.org/10.1021/acschembio.9b00610
Autor:
Michelle R. Robinson, Edwin E. Escobar, Jennifer S. Brodbelt, M. Rachel Mehaffey, Nathaniel T. Burkholder, Wanjie Yang, Zhao Zhang, Seema Irani, Karan R. Kathuria, Joshua E. Mayfield, Yan Zhang, Nicholas A Prescott, Sarah N. Sipe, Zhijie Liu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b89da89095279049161cdf2bd54afeb2
https://doi.org/10.7554/elife.48725.020
https://doi.org/10.7554/elife.48725.020
Autor:
Wanjie Yang, Zhao Zhang, M. Rachel Mehaffey, Nathaniel T. Burkholder, Jennifer S. Brodbelt, Michelle R. Robinson, Joshua E. Mayfield, Karan R. Kathuria, Seema Irani, Zhijie Liu, Yan Zhang, Nicholas A Prescott, Sarah N. Sipe, Edwin E. Escobar
SummaryThe Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of RNA polymerase II’s C-terminal domain (CTD) and is essential for the transition from transcription initiation to elongationin vivo. Surprisingly, P-TEFb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd05bd6f3dfa0c2bf4cc0410adb63a74