Clinical end points for developing pharmaceuticals to manage patients with a sporadic or genetic risk of colorectal cancer

Autor: Eugene W. Gerner, Jason A. Zell, Alfred M Cohen, Nathaniel S. Rial

Publikováno v: Expert Review of Gastroenterology & Hepatology. 6:507-517

To reduce the morbidity and mortality from colorectal cancer, current clinical practice focuses on screening for early detection and polypectomy as a form of secondary prevention, complemented with surgical interventions when appropriate. No pharmace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3499d1322cef3a7b8824204a3a13b168
https://doi.org/10.1586/egh.12.23

Enhanced visibility of colonic neoplasms using formulaic ratio imaging of native fluorescence

Autor: Bhaskar, Banerjee, Nathaniel S, Rial, Timothy, Renkoski, Logan R, Graves, Sirandon A H, Reid, Chengcheng, Hu, Vassiliki L, Tsikitis, Valentine, Nfonsom, Judith, Pugh, Urs, Utzinger

Publikováno v: Lasers in surgery and medicine. 45(9)

Colonoscopy is the preferred method for colon cancer screening, but can miss polyps and flat neoplasms with low color contrast. The objective was to develop a new autofluorescence method that improves image contrast of colonic neoplasms.We selected t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::393b8fa363e386c915bf87d3aea7a0f1
https://pubmed.ncbi.nlm.nih.gov/24114774

Tryptophan autofluorescence imaging of neoplasms of the human colon

Autor: Bhaskar Banerjee, Hemanth Gavini, Timothy E. Renkoski, Logan R. Graves, Urs Utzinger, Vassiliki L. Tsikitis, Valentine Nfonsam, Nathaniel S. Rial, Piyush Tiwari, Judith Pugh

Publikováno v: Journal of biomedical optics. 17(1)

Detection of flat neoplasia is a major challenge in colorectal cancer screening, as missed lesions can lead to the development of an unexpected 'incident' cancer prior to the subsequent endoscopy. The use of a tryptophan-related autofluorescence has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20619e8cc2d4210eaaa974e4f3ae195
https://pubmed.ncbi.nlm.nih.gov/22352653

Use of endoscopic ultrasound for diagnosis of cholangiocarcinoma in auto-immune hepatitis

Autor: Achyut K. Bhattacharyya, Abdul Nadir, Jeffrey T. Henderson, Nathaniel S. Rial, John T. Cunningham

Publikováno v: World journal of gastrointestinal endoscopy. 2(12)

In this report, a patient was exposed to an herbal remedy for hypercholesterolemia. She became acutely jaundiced while taking the remedy and presented for medical care. Endoscopic ultrasound was utilized, and found a distal common bile duct mass. End

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b549c13ae3a6bb7a2af8c3e129b315
https://pubmed.ncbi.nlm.nih.gov/21191514

Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention

Autor: Frank L. Meyskens, Nathaniel S. Rial, Eugene W. Gerner

Publikováno v: Rial, NS; Jr, MFL; & Gerner, EW. (2009). Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention. ESSAYS IN BIOCHEMISTRY, VOL 46, 46, 111-124. doi: 10.1042/BSE0460008. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7768m4jb

Combination chemoprevention for cancer was proposed a quarter of a century ago, but has not been implemented in standard medical practice owing to limited efficacy and toxicity. Recent trials have targeted inflammation and polyamine biosynthesis, bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464e6f1c492393c49e21f2163232d016
http://www.escholarship.org/uc/item/7768m4jb