Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Nathaniel R. Landau"'
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Currently authorized COVID-19 vaccines induce humoral and cellular responses to epitopes in the SARS-CoV-2 spike protein, though the relative roles of antibodies and T cells in protection are not well understood. To understand the role of vaccine-eli
Externí odkaz:
https://doaj.org/article/550e7accedfb47f8955e0c5aae11bfe3
Autor:
Ralf Duerr, Hao Zhou, Takuya Tada, Dacia Dimartino, Christian Marier, Paul Zappile, Guiqing Wang, Jonathan Plitnick, Sara B. Griesemer, Roxanne Girardin, Jessica Machowski, Sean Bialosuknia, Erica Lasek-Nesselquist, Samuel L. Hong, Guy Baele, Meike Dittmann, Mila B. Ortigoza, Prithiv J. Prasad, Kathleen McDonough, Nathaniel R. Landau, Kirsten St George, Adriana Heguy
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106075- (2023)
Summary: The emergence of recombinant viruses is a threat to public health, as recombination may integrate variant-specific features that together result in escape from treatment or immunity. The selective advantages of recombinant SARS-CoV-2 isolate
Externí odkaz:
https://doaj.org/article/585eec9eafc5429bbcaa9a950f5d24d1
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106092- (2023)
Summary: The emergence of SARS-CoV-2 variants with highly mutated spike proteins has presented an obstacle to the use of monoclonal antibodies for the prevention and treatment of SARS-CoV-2 infection. We show that a high-affinity receptor decoy prote
Externí odkaz:
https://doaj.org/article/e252738bdcd645f3aa65533b3a95eb93
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Lentiviral vector–based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection
Externí odkaz:
https://doaj.org/article/3bfe8cd57d9b48468cad25ba2d2392ac
Autor:
Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, André Figueiredo Rendeiro, Tuo Zhang, Skyler Uhl, Brienne C. Lubor, Vasuretha Chandar, Cristianel Gil, Wei Zhang, Brittany J. Dodson, Jeroen Bastiaans, Malavika Prabhu, Sean Houghton, David Redmond, Christine M. Salvatore, Yawei J. Yang, Olivier Elemento, Rebecca N. Baergen, Benjamin R. tenOever, Nathaniel R. Landau, Shuibing Chen, Robert E. Schwartz, Heidi Stuhlmann
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104223- (2022)
Summary: The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and subgenomic RNA in 22 out of 52 placentas. Placentas from two moth
Externí odkaz:
https://doaj.org/article/10e8c8bb49714f07ba4f189eb87775e5
Autor:
Maria G. Noval, Maria E. Kaczmarek, Akiko Koide, Bruno A. Rodriguez-Rodriguez, Ping Louie, Takuya Tada, Takamitsu Hattori, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Andrew Bazley, Maren de Vries, Marie I. Samanovic, Jeffrey N. Weiser, Ioannis Aifantis, Joan Cangiarella, Mark J. Mulligan, Ludovic Desvignes, Meike Dittmann, Nathaniel R. Landau, Maria Aguero-Rosenfeld, Shohei Koide, Kenneth A. Stapleford
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutraliz
Externí odkaz:
https://doaj.org/article/431b486be8244906b88b8f8c1a505e1f
Autor:
Takuya Tada, Hao Zhou, Marie I. Samanovic, Belinda M. Dcosta, Amber Cornelius, Ramin S. Herati, Mark J. Mulligan, Nathaniel R. Landau
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine effectiveness. Here, neutralizing antibody titers elicited by mRNA-based and adenoviral vector-based vaccines against variant pseudotyped vir
Externí odkaz:
https://doaj.org/article/445e7b65f7b844738afa2a02748999f8
Autor:
Claudio Counoupas, Paco Pino, Alberto O. Stella, Caroline Ashley, Hannah Lukeman, Nayan D. Bhattacharyya, Takuya Tada, Stephanie Anchisi, Charles Metayer, Jacopo Martinis, Anupriya Aggarwal, Belinda M. Dcosta, Warwick J. Britton, Joeri Kint, Maria J. Wurm, Nathaniel R. Landau, Megan Steain, Stuart G. Turville, Florian M. Wurm, Sunil A. David, James A. Triccas
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine that affords elevated, sust
Externí odkaz:
https://doaj.org/article/215dbedfcba04207b2b7b97f024ad384
Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
Autor:
Takuya Tada, Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Mark J. Mulligan, Nathaniel R. Landau
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103341- (2021)
Summary: Highly transmissible SARS-CoV-2 variants identified in India and designated B.1.617, Kappa (B.1.617.1), Delta (B.1.617.2), B.1.618, and B.1.36.29 contain spike mutations L452R, T478K, E484K, E484Q, and N440K located within the spike receptor
Externí odkaz:
https://doaj.org/article/4a04efff253c4798a3fb65a02845653c
Autor:
Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Mark J. Mulligan, Nathaniel R. Landau, Takuya Tada
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT DNA sequence analysis recently identified the novel SARS-CoV-2 variant B.1.526 that is spreading at an alarming rate in the New York City area. Two versions of the variant were identified, both with the prevalent D614G mutation in the spike
Externí odkaz:
https://doaj.org/article/d27f99fff4a1464d856ab08b87f4e537