Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria

Autor: Nadia Eusebio, Adriana Rego, Nathaniel R. Glasser, Raquel Castelo-Branco, Emily P. Balskus, Pedro N. Leão

Publikováno v: BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)

Abstract Background Halogenation is a recurring feature in natural products, especially those from marine organisms. The selectivity with which halogenating enzymes act on their substrates renders halogenases interesting targets for biocatalyst devel

Externí odkaz: https://doaj.org/article/dbc890e201f24f9d92e5dd7ccb4aa613

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

Autor: Raaj S. Mehta, Jared R. Mayers, Yancong Zhang, Amrisha Bhosle, Nathaniel R. Glasser, Long H. Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N. Ananthakrishnan, Eric A. Franzosa, Emily P. Balskus, Andrew T. Chan, Curtis Huttenhower

For decades, variability in clinical efficacy of the widely used inflammatory bowel disease (IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and inactivation by gut microbes. Identification of the responsible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ead2b03eda78b2c549d6b59b5952e9
https://resolver.caltech.edu/CaltechAUTHORS:20230321-823036300.93

Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

Autor: Cassidy Johnson, Terry B. Ruskoski, Nathaniel R. Glasser, Katherine M. Davis, Denise Okafor, Emily P. Balskus, Amie K. Boal, Nathaniel R. Braffman

Publikováno v: eLife. 11

The cyanobacterial enzyme CylK assembles the cylindrocyclophane natural products by performing two unusual alkylation reactions, forming new carbon-carbon bonds between aromatic rings and secondary alkyl halide substrates. This transformation is unpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62045a35ff4ced5cc2f7015e9fa7020f
https://doi.org/10.7554/elife.75761

Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

Autor: Nathaniel R. Glasser, Emily P. Balskus, Nelly Brugerolle de Fraissinette, Caroline Rouger, Pedro N. Leão, Deniz Tasdemir, Teresa P. Martins, Sara Freitas

Publikováno v: Natural Product Reports
Natural Product Reports, Royal Society of Chemistry, 2019, 36 (10), pp.1437-1461. ⟨10.1039/c8np00080h⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Natural Product Reports, 36 (10). pp. 1437-1461.

This review covers the structure, synthesis, biological activity, biosynthesis and distribution of cyanobacterial alkylresorcinols.
Covering: up to 2019 Alkylresorcinols are amphiphilic metabolites, well-known for their diverse biological activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c1cdf02ccdcdb3350c126c4ce9be54

Refinement of metabolite detection in cystic fibrosis sputum reveals heme correlates with lung function decline

Autor: Nathaniel R Glasser, Ryan C Hunter, Theodore G Liou, Dianne K Newman, Mountain West CF Consortium Investigators

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226578 (2019)

The bacterial growth environment within cystic fibrosis (CF) sputum is complex, dynamic, and shaped by both host and microbial processes. Characterization of the chemical parameters within sputum that stimulate the in vivo growth of airway pathogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bb6f2aaf521350b47dee41529ab06a
https://doi.org/10.1371/journal.pone.0226578