Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nathaniel R. Bennett"'
Autor:
Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design success rate is low. Here, we explo
Externí odkaz:
https://doaj.org/article/279adbbdbddf4e41bbd9f4a899f986cf
Autor:
Susana Vázquez Torres, Philip J. Y. Leung, Isaac D. Lutz, Preetham Venkatesh, Joseph L. Watson, Fabian Hink, Huu-Hien Huynh, Andy Hsien-Wei Yeh, David Juergens, Nathaniel R. Bennett, Andrew N. Hoofnagle, Eric Huang, Michael J MacCoss, Marc Expòsit, Gyu Rie Lee, Paul M. Levine, Xinting Li, Mila Lamb, Elif Nihal Korkmaz, Jeff Nivala, Lance Stewart, Joseph M. Rogers, David Baker
Many peptide hormones form an alpha-helix upon binding their receptors1–4, and sensitive detection methods for them could contribute to better clinical management.De novoprotein design can now generate binders with high affinity and specificity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f71e8af52449b591ee281d1a65d41b
https://doi.org/10.1101/2022.12.10.519862
https://doi.org/10.1101/2022.12.10.519862
Autor:
Joseph L. Watson, David Juergens, Nathaniel R. Bennett, Brian L. Trippe, Jason Yim, Helen E. Eisenach, Woody Ahern, Andrew J. Borst, Robert J. Ragotte, Lukas F. Milles, Basile I. M. Wicky, Nikita Hanikel, Samuel J. Pellock, Alexis Courbet, William Sheffler, Jue Wang, Preetham Venkatesh, Isaac Sappington, Susana Vázquez Torres, Anna Lauko, Valentin De Bortoli, Emile Mathieu, Regina Barzilay, Tommi S. Jaakkola, Frank DiMaio, Minkyung Baek, David Baker
There has been considerable recent progress in designing new proteins using deep learning methods1–9. Despite this progress, a general deep learning framework for protein design that enables solution of a wide range of design challenges, includingd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33b3dc2111101afaf7ffd55bbbc5fd12
https://doi.org/10.1101/2022.12.09.519842
https://doi.org/10.1101/2022.12.09.519842
Autor:
Ryan L. Clark, Nathaniel R. Bennett, Haoxiang Lyu, Gina C. Gordon, Brian F. Pfleger, Thatcher W. Root
Publikováno v:
ACS Synthetic Biology. 7:384-391
As researchers engineer cyanobacteria for biotechnological applications, we must consider potential environmental release of these organisms. Previous theoretical work has considered cyanobacterial containment through elimination of the CO2-concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b103a0a80230552d2d37e7fe129a2d5
https://doi.org/10.1021/acssynbio.7b00377
https://doi.org/10.1021/acssynbio.7b00377
Autor:
Aakash Deshpande, Sadie M. Johnson, Ian A. Schrack, Lauren A. Harasymiw, Benjamin J. Hackel, Lawrence A. Stern, Nathaniel R. Bennett, Melissa K. Gardner
Publikováno v:
Biotechnology and Bioengineering. 113:2328-2341
Yeast surface display has proven to be an effective tool in the discovery and evolution of ligands with new or improved binding activity. Selections for binding activity are generally carried out using immobilized or fluorescently labeled soluble dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eb0affecebe88cd73044ddf66269bab
https://doi.org/10.1002/bit.26001
https://doi.org/10.1002/bit.26001
Autor:
Ryan L, Clark, Gina C, Gordon, Nathaniel R, Bennett, Haoxiang, Lyu, Thatcher W, Root, Brian F, Pfleger
Publikováno v:
ACS synthetic biology. 7(2)
As researchers engineer cyanobacteria for biotechnological applications, we must consider potential environmental release of these organisms. Previous theoretical work has considered cyanobacterial containment through elimination of the CO2-concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9f9f24c79d67758e626042c226edbd3
https://pubmed.ncbi.nlm.nih.gov/29320853
https://pubmed.ncbi.nlm.nih.gov/29320853
Autor:
Lawrence A, Stern, Ian A, Schrack, Sadie M, Johnson, Aakash, Deshpande, Nathaniel R, Bennett, Lauren A, Harasymiw, Melissa K, Gardner, Benjamin J, Hackel
Publikováno v:
Biotechnology and bioengineering. 113(11)
Yeast surface display has proven to be an effective tool in the discovery and evolution of ligands with new or improved binding activity. Selections for binding activity are generally carried out using immobilized or fluorescently labeled soluble dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d6114f4cec25d1e8aa71ffcfcfdcb01
https://pubmed.ncbi.nlm.nih.gov/27144954
https://pubmed.ncbi.nlm.nih.gov/27144954