Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nathaniel M. Vacanti"'
Autor:
Donald Long, Jr., Marina Chan, Mingqi Han, Zeal Kamdar, Rosanna K. Ma, Pei-Yin Tsai, Adam B. Francisco, Joeva Barrow, David B. Shackelford, Mark Yarchoan, Matthew J. McBride, Lukas M. Orre, Nathaniel M. Vacanti, Taranjit S. Gujral, Praveen Sethupathy
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101699- (2024)
Summary: Fibrolamellar carcinoma (FLC) is a rare, lethal, early-onset liver cancer with a critical need for new therapeutics. The primary driver in FLC is the fusion oncoprotein, DNAJ-PKAc, which remains challenging to target therapeutically. It is c
Externí odkaz:
https://doaj.org/article/5fee8c91d0e84541891ec3ad5b4cbeeb
Autor:
Heesoo Jeong, Nathaniel M. Vacanti
Publikováno v:
Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract The kinetics and localization of the reactions of metabolism are coordinated by the enzymes that catalyze them. These enzymes are controlled via a myriad of mechanisms including inhibition/activation by metabolites, compartmentalization, the
Externí odkaz:
https://doaj.org/article/f1017c06d61d412da0ef5e5141c8de10
Autor:
Henrik J. Johansson, Fabio Socciarelli, Nathaniel M. Vacanti, Mads H. Haugen, Yafeng Zhu, Ioannis Siavelis, Alejandro Fernandez-Woodbridge, Miriam R. Aure, Bengt Sennblad, Mattias Vesterlund, Rui M. Branca, Lukas M. Orre, Mikael Huss, Erik Fredlund, Elsa Beraki, Øystein Garred, Jorrit Boekel, Torill Sauer, Wei Zhao, Silje Nord, Elen K. Höglander, Daniel C. Jans, Hjalmar Brismar, Tonje H. Haukaas, Tone F. Bathen, Ellen Schlichting, Bjørn Naume, Consortia Oslo Breast Cancer Research Consortium (OSBREAC), Torben Luders, Elin Borgen, Vessela N. Kristensen, Hege G. Russnes, Ole Christian Lingjærde, Gordon B. Mills, Kristine K. Sahlberg, Anne-Lise Børresen-Dale, Janne Lehtiö
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Gene expression profiles can classify breast cancer into five clinically relevant subtypes. Here, the authors perform an in-depth quantitative profiling of the proteome of 45 breast tumors, and show they can recapitulate the transcriptome-based class
Externí odkaz:
https://doaj.org/article/6d38d3e496e94ae593fe7bedce5833e0
Autor:
Heesoo Jeong, Yan Yu, Henrik J. Johansson, Frank C. Schroeder, Janne Lehtiö, Nathaniel M. Vacanti
Publikováno v:
Metabolites, Vol 11, Iss 5, p 310 (2021)
Stable-isotope tracing is a method to measure intracellular metabolic pathway utilization by feeding a cellular system a stable-isotope-labeled tracer nutrient. The power of the method to resolve differential pathway utilization is derived from the e
Externí odkaz:
https://doaj.org/article/721113d7d9c848ff86a1cab796832411
Autor:
Elena Panizza, Brandon D Regalado, Fangyu Wang, Ichiro Nakano, Nathaniel M Vacanti, Richard A Cerione, Marc A Antonyak
Publikováno v:
Life Science Alliance. 6:e202201680
Tumor-initiating cells contained within the aggressive brain tumor glioma (glioma stem cells, GSCs) promote radioresistance and disease recurrence. However, mechanisms of resistance are not well understood. Herein, we show that the proteome-level reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dc05404b02d2a410afd4dd513111a8c
https://doi.org/10.26508/lsa.202201680
https://doi.org/10.26508/lsa.202201680
Autor:
Elena Panizza, Brandon D. Regalado, Fangyu Wang, Ichiro Nakano, Nathaniel M. Vacanti, Richard A. Cerione, Marc A. Antonyak
Glioma is a malignant brain tumor that is highly resistant to radiation and chemotherapy, where patients survive on average only 15 months after diagnosis. Furthering the understanding of mechanisms leading to radiation resistance of glioma is paramo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5658995060904e1b69bcc8073467f02d
https://doi.org/10.1101/2022.03.23.485479
https://doi.org/10.1101/2022.03.23.485479
Autor:
Yan Yu, Heesoo Jeong, Janne Lehtiö, Frank C. Schroeder, Henrik J. Johansson, Nathaniel M. Vacanti
Publikováno v:
Metabolites
Volume 11
Issue 5
Metabolites, Vol 11, Iss 310, p 310 (2021)
Volume 11
Issue 5
Metabolites, Vol 11, Iss 310, p 310 (2021)
Stable-isotope tracing is a method to measure intracellular metabolic pathway utilization by feeding a cellular system a stable-isotope-labeled tracer nutrient. The power of the method to resolve differential pathway utilization is derived from the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0999d36e99fae5e6fb9e393ca25d4a
Autor:
Elena Panizza, Anna E. Thalacker-Mercer, Abby Benvie, Martha S. Field, Nathaniel M. Vacanti, Jamie E. Blum, Daniel C. Berry, Brandon J Gheller
Publikováno v:
J Nutr
BACKGROUND: Skeletal muscle progenitor cells (MPCs) repair damaged muscle postinjury. Pyruvate kinase M2 (PKM2) is a glycolytic enzyme (canonical activity) that can also interact with other proteins (noncanonical activity) to modify diverse cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd8813abf59392421f37ec70fcb2eb6
https://pubmed.ncbi.nlm.nih.gov/34383048
https://pubmed.ncbi.nlm.nih.gov/34383048
Autor:
Elena Panizza, Brandon D. Regalado, Fangyu Wang, Robert J. Munroe, Nathaniel M. Vacanti, Marc A. Antonyak, Richard A. Cerione
Publikováno v:
Molecular Cancer Therapeutics. 20:P093-P093
Glioma accounts for 80% of malignant brain tumors. Standard treatment for glioma involves surgical resection followed by radiation therapy and chemotherapy, however, tumors recur leading to death in 12 to 18 months on average. Gliomas contain tumor-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77fb46b41aa872db0f729a3719f2e7c4
https://doi.org/10.1158/1535-7163.targ-21-p093
https://doi.org/10.1158/1535-7163.targ-21-p093
Autor:
Nathaniel M, Vacanti
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1862
This chapter is intended to introduce the fundamental principles of the heat map, the most widely used medium to present high-throughput data, to scientists unaccustomed to analyzing large data sets. Its scope includes describing the general features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14739b01b011a28f42238a4854ac822e
https://pubmed.ncbi.nlm.nih.gov/30315475
https://pubmed.ncbi.nlm.nih.gov/30315475