Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Nathaniel M. Alpert"'
Autor:
Felicitas J. Detmer, Nathaniel M. Alpert, Sung-Hyun Moon, Maeva Dhaynaut, J. Luis Guerrero, Nicolas J. Guehl, Fangxu Xing, Pedro Brugarolas, Timothy M. Shoup, Marc D. Normandin, Matthieu Pelletier-Galarneau, Georges El Fakhri, Yoann Petibon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this proof-of-principle study, we investigated whether PET mapping of cardiac membrane potential, an indicator of mitochondrial function, could detect
Externí odkaz:
https://doaj.org/article/45f72c7eae84477dbaf9f917eb1916ed
Autor:
Yoann Petibon, Nathaniel M. Alpert, Jinsong Ouyang, Diego A. Pizzagalli, Cristina Cusin, Maurizio Fava, Georges El Fakhri, Marc D. Normandin
Publikováno v:
NeuroImage, Vol 221, Iss , Pp 117154- (2020)
Receptor ligand-based dynamic Positron Emission Tomography (PET) permits the measurement of neurotransmitter release in the human brain. For single-scan paradigms, the conventional method of estimating changes in neurotransmitter levels relies on fit
Externí odkaz:
https://doaj.org/article/3523c983044e4339a9631ff14d7134ae
Autor:
Nathaniel M. Alpert, Matthieu Pelletier-Galarneau, Sally Ji Who Kim, Yoann Petibon, Tao Sun, Karla M. Ramos-Torres, Marc D. Normandin, Georges El Fakhri
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundWe recently reported a method using positron emission tomography (PET) and the tracer 18F-labeled tetraphenylphosphonium (18F-TPP+) for mapping the tissue (i.e., cellular plus mitochondrial) membrane potential (ΔΨT) in the myocardium. The
Externí odkaz:
https://doaj.org/article/f75d9d85d221431185f1fd3c04e573e4
Autor:
Sally Ji Who Kim, Matthieu Pelletier-Galarneau, Nicolas Guehl, Paul Kyu Han, Georges El Fakhri, Nathaniel M. Alpert, Chao Ma, Yoann Petibon, Daniel Yokell, Marc D. Normandin, Felicitas J. Detmer
Publikováno v:
Eur J Nucl Med Mol Imaging
PURPOSE: Alteration in mitochondrial membrane potential (ΔΨ(m)) is an important feature of many pathologic processes, including heart failure, cardiotoxicity, ventricular arrhythmia, and myocardial hypertrophy. We present the first in vivo, noninva
Autor:
Georges El Fakhri, Jinsong Ouyang, Tao Sun, Sally Ji Who Kim, Nathaniel M. Alpert, Yoann Petibon, Paul Kyu Han, Chao Ma
Publikováno v:
Med Phys
PURPOSE: Patient body motion during a cardiac Positron Emission Tomography (PET) scan can severely degrade image quality. We propose and evaluate a novel method to detect, estimate, and correct body motion in cardiac PET. METHODS: Our method consists
Autor:
Matthieu Pelletier-Galarneau, Georges El Fakhri, Chao Ma, Nathaniel M. Alpert, Yoann Petibon, Marc D. Normandin, Felicitas J. Detmer
Publikováno v:
Curr Cardiol Rep
PURPOSE OF REVIEW: To present a method enabling in-vivo quantification of tissue membrane potential (ΔΨ(T)), a proxy of mitochondrial membrane potential (ΔΨ(m)), to review the origin and role of ΔΨ(m), and highlight potential applications of my
Autor:
Daniel G. Dillon, Marc D. Normandin, Ashley K. Meyer, David J. Crowley, Nathaniel M. Alpert, Diego A. Pizzagalli, Emily L. Belleau, Cristina Cusin, Aava Jahan, Maurizio Fava, Yoann Petibon, Georges El Fakhri, Jacob M. Hooker
Publikováno v:
Biological Psychiatry. 89:S171-S172
Autor:
Nicolas J, Guehl, Matthieu, Pelletier-Galarneau, Dustin W, Wooten, J Luis, Guerrero, Aurélie, Kas, Marc D, Normandin, Georges El, Fakhri, Nathaniel M, Alpert
Publikováno v:
Circ Cardiovasc Imaging
BACKGROUND: We previously proposed a technique for quantitative measurement of rest and stress absolute myocardial blood flow (MBF) using a two-injection single-scan imaging session. Recently, we validated the method in a pig model for the long-lived
Autor:
Nicolas Guehl, Leon M. Ptaszek, Georges El Fakhri, Dustin Wooten, Marc D. Normandin, Jeremy N. Ruskin, Guy Rozen, Jonghye Woo, Timothy M. Shoup, Nathaniel M. Alpert
Publikováno v:
Medical Physics. 44:4643-4651
Purpose We have recently reported a method for measuring rest-stress myocardial blood flow (MBF) using a single, relatively short, PET scan session. The method requires two IV tracer injections, one to initiate rest imaging and one at peak stress. We