Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nathaniel L. Elsen"'
Autor:
John Shanley, Fan Pu, Jon D. Williams, Nathaniel L. Elsen, Sujatha M. Gopalakrishnan, Jeffrey Y Pan, Andrew J. Radosevich
Publikováno v:
SLAS Technology, Vol 29, Iss 4, Pp 100163- (2024)
Over the last 5 years, IR-MALDESI-MS (Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry) has been demonstrated for use in a range of high-throughput biochemical and cellular assays with remarkable sample acquisition
Externí odkaz:
https://doaj.org/article/ec3b9207539646c891031c90f9573eb1
Autor:
Ahmed A. Samatar, Lata Jayaraman, Leigh Zawel, Stephen Fawell, Alan Cooper, Anthony Mannarino, Nathaniel L. Elsen, Stuart Black, Priya Dayananth, Clifford R. Restaino, Daniel McMasters, Jaren Arbanas, Gottfried K. Schroeder, My Sam Mansueto, Alan Hruza, Erick J. Morris, Sharda Jha
HTRF and Biacore binding data for active and inactive ERK1 in the presence of SCH772984
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a41d041f5824e4e438c00c030ecb53b
https://doi.org/10.1158/1535-7163.22509012.v1
https://doi.org/10.1158/1535-7163.22509012.v1
Autor:
Ahmed A. Samatar, Lata Jayaraman, Leigh Zawel, Stephen Fawell, Alan Cooper, Anthony Mannarino, Nathaniel L. Elsen, Stuart Black, Priya Dayananth, Clifford R. Restaino, Daniel McMasters, Jaren Arbanas, Gottfried K. Schroeder, My Sam Mansueto, Alan Hruza, Erick J. Morris, Sharda Jha
HTRF and Biacore binding data for active and inactive ERK1 in the presence of SCH772984
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3185945c7ae768bd2e93b8d986a09ade
https://doi.org/10.1158/1535-7163.22508997
https://doi.org/10.1158/1535-7163.22508997
Autor:
Ahmed A. Samatar, Lata Jayaraman, Leigh Zawel, Stephen Fawell, Alan Cooper, Anthony Mannarino, Nathaniel L. Elsen, Stuart Black, Priya Dayananth, Clifford R. Restaino, Daniel McMasters, Jaren Arbanas, Gottfried K. Schroeder, My Sam Mansueto, Alan Hruza, Erick J. Morris, Sharda Jha
Theoretical maximum binding capacity of immobilized ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae21590fd6fe473ad9f65db7f2896fb
https://doi.org/10.1158/1535-7163.22509000.v1
https://doi.org/10.1158/1535-7163.22509000.v1
Autor:
Fan Pu, Andrew J. Radosevich, Brett G. Bruckner, David A. Fontaine, Sanjay C. Panchal, Jon D. Williams, Sujatha M. Gopalakrishnan, Nathaniel L. Elsen
Cellular pharmacodynamic assays are crucial aspects of lead optimization programs in drug discovery. These assays are sometimes difficult to develop, oftentimes distal from the target and frequently low throughput which necessitates their incorporati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eca35ab5ad650093f487c1838a90771
https://doi.org/10.1101/2023.01.30.526319
https://doi.org/10.1101/2023.01.30.526319
Autor:
Fan Pu, Kevan T. Knizner, Matthew T. Robey, Andrew J. Radosevich, Scott A. Ugrin, Nathaniel L. Elsen, Kenneth R. Durbin, Jon D. Williams
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33(12)
Deconvolution from intact protein mass-to-charge spectra to mass spectra is essential to generate interpretable data for mass spectrometry (MS) platforms coupled to ionization sources that produce multiply charged species. Infrared matrix-assisted la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070444c29f7de7237a89d0c79f3468a3
https://pubmed.ncbi.nlm.nih.gov/36378849
https://pubmed.ncbi.nlm.nih.gov/36378849
Autor:
Kevan T. Knizner, Jacob P. Guymon, Kenneth P. Garrard, Guy Bouvrée, Jeffrey Manni, Jan-Peter Hauschild, Kerstin Strupat, Kyle L. Fort, Lee Earley, Eloy R. Wouters, Fan Pu, Andrew J. Radosevich, Nathaniel L. Elsen, Jon D. Williams, Mark R. Pankow, David C. Muddiman
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33(11)
Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is a hybrid, ambient ionization source that combines the advantages of electrospray ionization and matrix-assisted laser desorption/ionization, making it a versatile tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e8a08965e1954488ff96ba364c23fc
https://pubmed.ncbi.nlm.nih.gov/36173393
https://pubmed.ncbi.nlm.nih.gov/36173393
Autor:
Fan Pu, Scott A. Ugrin, Andrew J. Radosevich, David Chang-Yen, James W. Sawicki, Nari N. Talaty, Nathaniel L. Elsen, Jon D. Williams
Publikováno v:
Analytical chemistry. 94(39)
Mass spectrometry (MS) is the primary analytical tool used to characterize proteins within the biopharmaceutical industry. Electrospray ionization (ESI) coupled to liquid chromatography (LC) is the current gold standard for intact protein analysis. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdf4442c6d50c7f817dec31bdee3dff
https://pubmed.ncbi.nlm.nih.gov/36129783
https://pubmed.ncbi.nlm.nih.gov/36129783
Autor:
Nathaniel L. Elsen, Sujatha M. Gopalakrishnan, David Chang-Yen, Andrew J. Radosevich, James W. Sawicki, Jon D. Williams, Fan Pu, Nari Talaty
Publikováno v:
Analytical Chemistry. 93:6792-6800
Mass spectrometry (MS) can provide high sensitivity and specificity for biochemical assays without the requirement of labels, eliminating the risk of assay interference. However, its use had been limited to lower-throughput assays due to the need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cde58dd559d38ee66484fb748cc1c54
https://doi.org/10.1021/acs.analchem.1c00737
https://doi.org/10.1021/acs.analchem.1c00737
Autor:
Kevan T. Knizner, Michael C. Bagley, Fan Pu, Nathaniel L. Elsen, Jon D. Williams, David C. Muddiman
Publikováno v:
Journal of mass spectrometry : JMS. 57(6)
Mass spectrometry (MS) is an effective analytical tool for high-throughput screening (HTS) in the drug discovery field. Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MS is a high-throughput platform that has achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb74be38d44ef6e4a11b6b8a5c7cec14
https://pubmed.ncbi.nlm.nih.gov/35678360
https://pubmed.ncbi.nlm.nih.gov/35678360