Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nathaniel K. Minami"'
Autor:
Jonathan Zhangi Ho, Susanne M Anderson, Daniel V. Siev, Kemp Scott Jeffrey, Thomas G. Nolan, John A. Gaudette, Annette E Bradbury, Nathaniel K. Minami, Komandla Malla Reddy, Gian-Luca Araldi, John E Reiner, Lala Mamedova, Tony Gibson, Jingrong Jean Cui, J. Edward Semple
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2925-2930
Novel, potent, and highly selective classes of thrombin inhibitors were identified, which resulted from judicious combination of P4-aromatics and P2-P3-heterocyclic dipeptide surrogates with weakly basic (calcd pKa approximately non-basic-8.6) bicycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28d17be750a8171e753d60364adb4bc
https://doi.org/10.1016/s0960-894x(02)00585-1
https://doi.org/10.1016/s0960-894x(02)00585-1
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2305-2309
Judicious combination of P-region sequences of highly potent anticoagulant proteins including NAP5, NAP6, Ecotin, and Antistasin with SAR from small molecule FXa inhibitors led to a series of chimeric inhibitors of formula 1a – j . We report herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a497e07097f3aed3032981ee195c8147
https://doi.org/10.1016/s0960-894x(00)00458-3
https://doi.org/10.1016/s0960-894x(00)00458-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2625-2628
Application of the Sharpless AD protocol to a series of alpha-(E)-benzylidene-delta-lactam precursors followed by selective deoxygenation provided efficient synthetic routes to the chiral quaternary alpha-hydroxy-gammalactam derivatives 4 and 5. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0163dd01340e289ed0010a309a46f4c9
https://doi.org/10.1016/s0960-894x(99)00448-5
https://doi.org/10.1016/s0960-894x(99)00448-5
Autor:
Terence K. Brunck, Ruth F. Nutt, William C. Ripka, J. Edward Semple, Nathaniel K. Minami, Susan Y. Tamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2421-2426
SAR and molecular modeling investigations on the potent and selective thrombin inhibitor 1b (CVS 1578) and related serine protease inhibitors led to the design of series 2a–g, featuring quaternary α-amino-α-benzyl-lactam scaffolds that serve as n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c4672470844f5a163ae72f03dc3e7a
https://doi.org/10.1016/s0960-894x(97)00446-0
https://doi.org/10.1016/s0960-894x(97)00446-0
Autor:
D. C. Rowley, Yu Ge, B. M. Richard, R. J. Ardecky, Erick A. Goldman, Daniel V. Siev, Timothy D. Owens, K. Haakanson, Alexander Tulinsky, Susan Yoshiko Tamura, Nathaniel K. Minami, William C. Ripka, S. H. Carpenter, Terence K. Brunck, T. G. Nolan, Ruth F. Nutt, Theresa Ha-Uong, J. E. Semple
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47682941c0c0982370f559c97d6112f2
https://doi.org/10.1002/chin.199708204
https://doi.org/10.1002/chin.199708204
Autor:
Susan Yoshiko Tamura, Terence K. Brunck, Nathaniel K. Minami, William C. Ripka, Ruth F. Nutt, J. E. Semple
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07c702464b0498da0f5596000b0547cb
https://doi.org/10.1002/chin.199804182
https://doi.org/10.1002/chin.199804182
Autor:
J. Edward Semple, David C. Rowley, Theresa H. Uong, Terence K. Brunck, Nathaniel K. Minami, Timothy D. Owens
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf465ada028c684c1c9226277082241c
https://doi.org/10.1002/chin.199917142
https://doi.org/10.1002/chin.199917142
Publikováno v:
ChemInform. 30
Application of the Sharpless AD protocol to a series of α-(E)-benzylidene-δ-lactam precursors followed by selective deoxygenation provided efficient synthetic routes to the chiral quaternary α-hydroxy-γ-lactam derivatives 4 and 5. These functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6db98f06eb6d90538ae0214d118db262
https://doi.org/10.1002/chin.199949129
https://doi.org/10.1002/chin.199949129
Autor:
John E Reiner, Daniel V Siev, Gian-Luca Araldi, Jingrong Jean Cui, Jonathan Z Ho, Komandla Malla Reddy, Lala Mamedova, Phong H Vu, Kuen-Shan S Lee, Nathaniel K Minami, Tony S Gibson, Susanne M Anderson, Annette E Bradbury, Thomas G Nolan, J.Edward Semple
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(8)
Investigations on P(2)-P(3)-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P(1)-arginine derivatives. The design, synthesis, and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42121ffe20de14bf71593d1d50196fff
https://pubmed.ncbi.nlm.nih.gov/11934589
https://pubmed.ncbi.nlm.nih.gov/11934589
Publikováno v:
ChemInform. 32
Judicious combination of P-region sequences of highly potent anticoagulant proteins including NAP5, NAP6, Ecotin, and Antistasin with SAR from small molecule FXa inhibitors led to a series of chimeric inhibitors of formula 1a – j . We report herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b63e4dc7ea8184b0223c282d02d4709e
https://doi.org/10.1002/chin.200103173
https://doi.org/10.1002/chin.200103173