Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Nathaniel J. Traaseth"'
Autor:
Jianping Li, Yan Li, Akiko Koide, Huihui Kuang, Victor J. Torres, Shohei Koide, Da-Neng Wang, Nathaniel J. Traaseth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Efflux pump antiporters confer drug resistance to bacteria by coupling proton import with the expulsion of antibiotics from the cytoplasm. Despite efforts there remains a lack of understanding as to how acid/base chemistry drives drug efflux
Externí odkaz:
https://doaj.org/article/adc805a7d0e7498a80ffffeceecb6f54
Autor:
Jianping Li, Ampon Sae Her, Alida Besch, Belen Ramirez-Cordero, Maureen Crames, James R. Banigan, Casey Mueller, William M. Marsiglia, Yingkai Zhang, Nathaniel J. Traaseth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The multidrug efflux transporter EmrE from Escherichia coli requires anionic residues in the substrate binding pocket for coupling drug transport with the proton motive force. Here, we show how protonation of a single membrane embedded gluta
Externí odkaz:
https://doaj.org/article/cc00286393ca4bfca62431b57cd1c7f6
Autor:
Huaibin Chen, Zhifeng Huang, Kaushik Dutta, Steven Blais, Thomas A. Neubert, Xiaokun Li, David Cowburn, Nathaniel J. Traaseth, Moosa Mohammadi
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 376-384 (2013)
The basal (ligand-independent) kinase activity of receptor tyrosine kinases (RTKs) promotes trans-phosphorylation on activation loop tyrosines upon ligand-induced receptor dimerization, thus upregulating intrinsic kinase activity and triggering intra
Externí odkaz:
https://doaj.org/article/b9111ae027a44ba094c61ea2b3c0411d
Autor:
Nathaniel J. Traaseth
Publikováno v:
Two‐Dimensional (2D) NMR Methods. :195-207
Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Many types of human cancers are being treated with small molecule ATP-competitive inhibitors targeting the kinase domain of receptor tyrosine kinases. Despite initial successful remission, long-term treatment almost inevitably leads to the emergence
Autor:
Douglas N. Brawley, David B. Sauer, Jianping Li, Xuhui Zheng, Akiko Koide, Ganesh S. Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S. Arora, Shohei Koide, Victor J. Torres, Da-Neng Wang, Nathaniel J. Traaseth
Publikováno v:
Nature Chemical Biology. 18:706-712
Publikováno v:
Angewandte Chemie International Edition. 61
Despite recent progress, it remains challenging to program biomacromolecules to assemble into discrete nanostructures with pre-determined sizes and topologies. We report here a novel strategy to address this challenge. By using two orthogonal pairs o
Autor:
Joseph Katigbak, Guang Liang, Thomas A. Neubert, Jinghong Ma, Lili Fu, Moosa Mohammadi, William M. Marsiglia, Yingkai Zhang, Xiaokun Li, Huaibin Chen, David J. Kemble, Lingfeng Chen, Nathaniel J. Traaseth, Gongqin Sun, Hediye Erdjument-Bromage
Publikováno v:
Nat Chem Biol
A long-standing mystery shrouds the mechanism by which catalytically repressed receptor tyrosine kinase domains accomplish transphosphorylation of activation loop (A-loop) tyrosines. Here we show that this reaction proceeds via an asymmetric complex
Publikováno v:
J Chem Educ
Design of undergraduate laboratory courses that provide meaningful research-based experiences enhance undergraduate curricula and prepare future graduate students for research careers. In this article, a Course-based Undergraduate Research Experience
Publikováno v:
Proc Natl Acad Sci U S A
EmrE is an Escherichia coli multidrug efflux pump and member of the small multidrug resistance (SMR) family that transports drugs as a homodimer by harnessing energy from the proton motive force. SMR family transporters contain a conserved glutamate