Výsledky vyhledávání - "Nathaniel J. Stillson"

In silico study of selective inhibition mechanism of S-adenosyl-L-methionine analogs for human DNA methyltransferase 3A

Autor: Nathaniel J. Stillson, Kyle E. Anderson, Norbert O. Reich

Publikováno v: Computational biology and chemistry. 102

Epigenetic mechanisms leading to transcriptional regulation, including DNA methylation, are frequently dysregulated in diverse cancers. Interfering with aberrant DNA methylation performed by DNA cytosine methyltransferases (DNMTs) is a clinically val

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd612356e9087d7c3ea0442961571e8a
https://pubmed.ncbi.nlm.nih.gov/36495748

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A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A

Autor: Chitoh Yung, Jonathan E. Sandoval, Sunzeyu Huang, Norbert O. Reich, Nathaniel J. Stillson

Publikováno v: Bioorganicmedicinal chemistry letters. 40

Screening of a small chemical library (Medicines for Malaria Venture Pathogen Box) identified two structurally related pyrazolone (inhibitor 1) and pyridazine (inhibitor 2) DNMT3A inhibitors with low micromolar inhibition constants. The uncompetitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831dd6a98a0b2eaa4aff1f8aae9d7bd5
https://pubmed.ncbi.nlm.nih.gov/33705897

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