Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nathaniel J. Henning"'
Autor:
Deepak Gurbani, Guangyan Du, Nathaniel J. Henning, Suman Rao, Asim K. Bera, Tinghu Zhang, Nathanael S. Gray, Kenneth D. Westover
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Unregulated Src activity promotes malignant processes in cancer, but no Src-directed targeted therapies are used clinically, possibly because early Src inhibitors produce off-target effects leading to toxicity. Improved selective Src inhibitors may e
Externí odkaz:
https://doaj.org/article/2ccc48f356d64ae1837bcf1a0936c482
Autor:
Patrick Moon, Charlotte M. Zammit, Qian Shao, Dustin Dovala, Lydia Boike, Nathaniel J. Henning, Mark Knapp, Jessica N. Spradlin, Carl C. Ward, Helene Wolleb, Daniel Fuller, Gabrielle Blake, Jason P. Murphy, Feng Wang, Yipin Lu, Stephanie A. Moquin, Laura Tandeske, Matthew J. Hesse, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, F. Dean Toste, Daniel K. Nomura
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87a50b5733f55cf44f9b43ee3e858a7
https://doi.org/10.1002/cbic.202300116
https://doi.org/10.1002/cbic.202300116
Covalent drugs have been used to treat diseases for more than a century, but tools that facilitate the rational design of covalent drugs have emerged more recently. The purposeful addition of reactive functional groups to existing ligands can enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15a31a9f6ff6edbdf348d9116215f75
https://escholarship.org/uc/item/1w40c1v9
https://escholarship.org/uc/item/1w40c1v9
Publikováno v:
Nature reviews. Drug discovery. 21(12)
Covalent drugs have been used to treat diseases for more than a century, but tools that facilitate the rational design of covalent drugs have emerged more recently. The purposeful addition of reactive functional groups to existing ligands can enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88dc6760f61bb95ba5f52f3e1cd262f8
https://pubmed.ncbi.nlm.nih.gov/36008483
https://pubmed.ncbi.nlm.nih.gov/36008483
Autor:
Nathaniel J. Henning, Andrew G. Manford, Jessica N. Spradlin, Scott M. Brittain, Erika Zhang, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Michael Rape, Daniel K. Nomura
Publikováno v:
J Am Chem Soc
Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883c232f223b56eeda2a0e64db5426bf
https://pubmed.ncbi.nlm.nih.gov/34994556
https://pubmed.ncbi.nlm.nih.gov/34994556
Autor:
Jake S. Hedges, Nathaniel J. Henning, Sebastian M. Fica-Contreras, Sydney O. Shuster, Sunhee Choi
Reacted with methylglyoxal (MGO), murine Aβ(1-40) (mAβ) produced significantly less superoxide anion (O2•–) compared to human Aβ(1-40) (hAβ). The reactions of MGO with mAβ(R13H), hAβ(H13F), Nα-acetyl-l-lysine, and Nα-acetyl-l-arginine imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c213403128f2fe4bc113cde27bd12767
Autor:
Guangyan Du, Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak, Katherine A. Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A. Eleuteri, Zhixiang He, Zhengnian Li, Hubert T. Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray
Publikováno v:
Cell Chemical Biology. 29:1470-1481.e31
Targeted protein degradation (TPD) uses small molecules to recruit E3 ubiquitin ligases into the proximity of proteins of interest, inducing ubiquitination-dependent degradation. A major bottleneck in the TPD field is the lack of accessible E3 ligase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd18917650df053c5eafa56606f1849a
https://doi.org/10.1016/j.chembiol.2022.08.003
https://doi.org/10.1016/j.chembiol.2022.08.003
Autor:
Nathaniel J. Henning, Scott M. Brittain, Lynn M. McGregor, John A. Tallarico, Hesse M, Carl C. Ward, Bridget P. Belcher, Lydia Boike, Jessica N. Spradlin, Markus Schirle, Jeffery M. McKenna, Dustin Dovala, Daniel K. Nomura
Targeted protein degradation is a powerful therapeutic modality that uses heterobifunctional small-molecules to induce proximity between E3 ubiquitin ligases and target proteins to ubiquitinate and degrade specific proteins of interest. However, many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38f2a0ff703641e9a40022f756281844
https://doi.org/10.1101/2021.04.30.441959
https://doi.org/10.1101/2021.04.30.441959
Autor:
John A. Tallarico, Jessica N. Spradlin, Scott M. Brittain, Michael Rape, Markus Schirle, Daniel K. Nomura, Jeffery M. McKenna, Andrew G. Manford, Nathaniel J. Henning
Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15554b8f90fe83d96da1d76719b9f0ed
https://doi.org/10.1101/2021.04.15.439993
https://doi.org/10.1101/2021.04.15.439993
Autor:
Nathaniel D Durfee, Nathaniel J. Henning, Sydney O. Shuster, Staci A. Hill, David R Stillman, Gregory Joon Kee Bowe, Sunhee Choi, Sebastian M. Fica-Contreras, Geoffrey D Vrla, Roger K. Sandwick, Kelly M Suralik
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 22:1211-1222
Extensive research has linked the amyloid-beta (Aβ) peptide to neurological dysfunction in Alzheimer's disease (AD). Insoluble Aβ plaques in the AD patient brain contain high concentrations of advanced glycation end-products (AGEs) as well as trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121d9b8bb8c4a9dee14181366c3c08c0
https://doi.org/10.1007/s00775-017-1497-5
https://doi.org/10.1007/s00775-017-1497-5