Výsledky vyhledávání - "Nathaniel F. Chikkala"

Induction of Long-Term Protective Effects against Heterologous Challenge in SIVhu-Infected Macaques

Autor: William M. Switzer, Nathaniel F. Chikkala, Aftab A. Ansari, Pavel Bostik, Debra R. Adams, Ronald A. Otten, Walid Heneine, Qizhi Yao, Francis J. Novembre, Harold M. McClure, Bharat Parekh, Vedapuri Shanmugam, Francois Villinger, Thomas M. Folks, Ann E. Mayne

Publikováno v: Virology. 278:194-206

A group of three rhesus macaques were inoculated with SIV isolated from a human (SIVhu) accidentally exposed and infected with SIVsm. Extensive sequence analyses of SIVhu obtained from the human and macaques following infection indicated the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8048b7996d51a8d5b335a5f071132eae
https://doi.org/10.1006/viro.2000.0651

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Immune and hematopoietic parameters in HIV-1-infected chimpanzees during clinical progression toward AIDS

Autor: Aftab A. Ansari, Francois Villinger, Silvana Z. Bucur, Nathaniel F. Chikkala, Sukhdev S. Brar, Francis J. Novembre, Gary T. Brice, Ann E. Mayne, Christopher D. Hillyer

Publikováno v: Journal of Medical Primatology. 26:11-18

Until recently, chimpanzees were considered susceptible to human immunodeficiency virus type 1 (HIV-1) infection, but refractory to disease induction based on the asymptomatic status of all experimentally infected chimpanzees after over 10 years post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b150df7d0752a21bed6a869aee10b39
https://doi.org/10.1111/j.1600-0684.1997.tb00314.x

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Restricted replication of vesicular stomatitis virus in T lymphocytes is coincident with a deficiency in a cellular protein kinase required for viral transcription

Autor: David E. Sleat, Amiya K. Banerjee, Subhash C. Gautam, Nathaniel F. Chikkala

Publikováno v: Journal of General Virology. 73:3125-3132

Vesicular stomatitis virus (VSV) fails to replicate in mouse T lymphocytes unless the cells have been mitogenically stimulated with concanavalin A (Con A). We have examined the possibility that the failure of VSV to replicate in unstimulated T lympho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38e1bea88e2ac8f6c5a57221b13fff0
https://doi.org/10.1099/0022-1317-73-12-3125

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L3T4 (CD4+) cells that mediate contact sensitivity to trinitrochlorobenzene express I-A determinants

Autor: Raymond R. Tubbs, Mark Edinger, Nathaniel F. Chikkala, Subhash C. Gautam, James A. Matriano

Publikováno v: Cellular Immunology. 135:27-41

The present study has further characterized the T cell-mediated inflammatory response of contact sensitivity (CS) to the hapten trinitrochlorobenzene (TNCB) in mice. A discernible CS response was found to be induced as early as 2 days after epicutane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b269d0c9b5685ab09a55efd5bf7b43d
https://doi.org/10.1016/0008-8749(91)90251-6

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In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS

Autor: Jonathan Adams, Francis J. Novembre, Francois Villinger, Aftab A. Ansari, Ann E. Mayne, Silvana Z. Bucur, Sukhdev S. Brar, Maurice K. Gately, Nathaniel F. Chikkala, Christopher D. Hillyer, Mark Lee, Pavel Bostik

Publikováno v: AIDS research and human retroviruses. 16(8)

The in vitro proliferative responses of macaque peripheral blood mononuclear cells (PBMCs) to IL-12 appeared similar before and early after SIV infection, whereas macaque PBMCs sampled during symptomatic stages of SIV infection showed markedly decrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83deedc75d065e0787dca3512e2fc053
https://pubmed.ncbi.nlm.nih.gov/10826482

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Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection

Autor: Sherif R. Zaki, Robert Swanepoel, Francois Villinger, Sukhdev S. Brar, Clarence J. Peters, Pierre E. Rollin, J. Bruce Sundstrom, Jörn Winter, Aftab A. Ansari, Nathaniel F. Chikkala

Publikováno v: The Journal of infectious diseases. 179

The role of immune mechanisms in the pathogenesis of Ebola hemorrhagic fever (EHF) remains to be elucidated. In this report, the serum cytokine levels of patients who died of EHF were compared with those of patients who recovered and those of control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a94dfaf13180c0bfcbccc47ba4c4f00
https://pubmed.ncbi.nlm.nih.gov/9988183

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Expression and in vitro evaluation of rhesus macaque wild type (wt) and modified CC chemokines

Autor: Christopher D. Hillyer, Nathaniel F. Chikkala, Jonathan Adams, William W. Cruikshank, Francois Villinger, Sukhdev S. Brar, Pavel Bostik, Aftab A. Ansari, Gary T. Brice

Publikováno v: Journal of medical primatology. 27(2-3)

Several human CC chemokines have been shown to inhibit HIV/ SIV infection in vitro, providing the rationale for their potential use in vivo. However, because of their inherent physiological effect, such chemokines are reasoned to be of limited therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3e2470e91cbae3cdbccf9e10383b24
https://pubmed.ncbi.nlm.nih.gov/9747952

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Development of a novel quantitative assay for the measurement of chloramphenicol acetyl transferase (CAT) mRNA

Autor: Thomas M. Folks, Daniel P. Bednarik, Aftab A. Ansari, Marlyse C. Knuchel, Francois Villinger, Nathaniel F. Chikkala

Publikováno v: Journal of virological methods. 48(2-3)

Most host cells transfected with chloramphenicol acetyl transferase (CAT) expressing plasmids display relatively low levels of constitutive CAT activity. While this is ideal to study factors that enhance gene transcription, decreases in CAT levels ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83eaf69e0801bd4c26eda21c20e5e030
https://pubmed.ncbi.nlm.nih.gov/7989447

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Differences in murine gut-associated lymphoid tissues in generating broadly nonspecific cytotoxic cells in response to interferon alpha A/D and interleukin 2

Autor: Subhash C. Gautam, Nathaniel F. Chikkala

Publikováno v: Cellular immunology. 135(2)

We examined the response of cells of murine gut-associated lymphoid tissues to agents that augment the activity of natural killer (NK) cells. Specifically, we studied the effect of polyinosinic: polycytidylic acid (Poly I:C) in vivo , and recombinant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2488dcb9a3987e9679882a72173cb94
https://pubmed.ncbi.nlm.nih.gov/2036676

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Oral administration of the contact sensitizer trinitrochlorobenzene: initial sensitization and subsequent appearance of a suppressor population

Autor: Subhash C. Gautam, Jack R. Battisto, Nathaniel F. Chikkala

Publikováno v: Cellular immunology. 125(2)

Our earlier studies have demonstrated that intragastric administration of the hapten trinitrochlorobenzene (TNCB) 2 to 3 weeks prior to attempting sensitization with epidermally applied hapten can abrogate development of systemic contact sensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9f9bcf767fddd4c9fad79dceb3d0a8
https://pubmed.ncbi.nlm.nih.gov/2137034

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