Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nathaniel D. Anderson"'
Autor:
Taryn D. Treger, John E. G. Lawrence, Nathaniel D. Anderson, Tim H. H. Coorens, Aleksandra Letunovska, Emilie Abby, Henry Lee-Six, Thomas R. W. Oliver, Reem Al-Saadi, Kjell Tullus, Guillaume Morcrette, J. Ciaran Hutchinson, Dyanne Rampling, Neil Sebire, Kathy Pritchard-Jones, Matthew D. Young, Thomas J. Mitchell, Philip H. Jones, Maxine Tran, Sam Behjati, Tanzina Chowdhury
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Reninomas are exceedingly rare renin-secreting kidney tumours that derive from juxtaglomerular cells, specialised smooth muscle cells that reside at the vascular inlet of glomeruli. They are the central component of the juxtaglomerular appar
Externí odkaz:
https://doaj.org/article/bf323a439c8641f5a4c650d7e939dabe
Autor:
Nicholas Light, Mehdi Layeghifard, Ayush Attery, Vallijah Subasri, Matthew Zatzman, Nathaniel D. Anderson, Rupal Hatkar, Sasha Blay, David Chen, Ana Novokmet, Fabio Fuligni, James Tran, Richard de Borja, Himanshi Agarwal, Larissa Waldman, Lisa M. Abegglen, Daniel Albertson, Jonathan L. Finlay, Jordan R. Hansford, Sam Behjati, Anita Villani, Moritz Gerstung, Ludmil B. Alexandrov, Gino R. Somers, Joshua D. Schiffman, Varda Rotter, David Malkin, Adam Shlien
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Li-Fraumeni syndrome (LFS) is associated with pathogenic germline TP53 variants and predisposes patients to cancer; understanding the evolution and drivers of LFS-related tumours remains crucial. Here, the authors analyse 22 LFS tumours using whole-g
Externí odkaz:
https://doaj.org/article/6313943fa94246f49c0f01dd1873ed40
Autor:
Mi K. Trinh, Clarissa N. Pacyna, Gerda Kildisiute, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Nathaniel D. Anderson, Eleonora Khabirova, Elena Prigmore, Karin Straathof, Sam Behjati, Matthew D. Young
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
The identification of cancer cells from single cell transcriptomes can be improved by detecting allelic imbalances due to copy number changes.
Externí odkaz:
https://doaj.org/article/220e9b9e0e1441249c0e227b1bf2a3ec
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Autor:
Nathaniel D. Anderson, Yael Babichev, Fabio Fuligni, Federico Comitani, Mehdi Layeghifard, Rosemarie E. Venier, Stefan C. Dentro, Anant Maheshwari, Sheena Guram, Claire Wunker, J. Drew Thompson, Kyoko E. Yuki, Huayun Hou, Matthew Zatzman, Nicholas Light, Marcus Q. Bernardini, Jay S. Wunder, Irene L. Andrulis, Peter Ferguson, Albiruni R. Abdul Razak, Carol J. Swallow, James J. Dowling, Rima S. Al-Awar, Richard Marcellus, Marjan Rouzbahman, Moritz Gerstung, Daniel Durocher, Ludmil B. Alexandrov, Brendan C. Dickson, Rebecca A. Gladdy, Adam Shlien
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with su
Externí odkaz:
https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128
Autor:
Julian Musa, Florencia Cidre-Aranaz, Marie-Ming Aynaud, Martin F. Orth, Maximilian M. L. Knott, Olivier Mirabeau, Gal Mazor, Mor Varon, Tilman L. B. Hölting, Sandrine Grossetête, Moritz Gartlgruber, Didier Surdez, Julia S. Gerke, Shunya Ohmura, Aruna Marchetto, Marlene Dallmayer, Michaela C. Baldauf, Stefanie Stein, Giuseppina Sannino, Jing Li, Laura Romero-Pérez, Frank Westermann, Wolfgang Hartmann, Uta Dirksen, Melissa Gymrek, Nathaniel D. Anderson, Adam Shlien, Barak Rotblat, Thomas Kirchner, Olivier Delattre, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA
Externí odkaz:
https://doaj.org/article/b15283577e6941feafb9a8d8c4019ddd
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations
Autor:
Anita Villani, Scott Davidson, Nisha Kanwar, Winnie W. Lo, Yisu Li, Sarah Cohen-Gogo, Fabio Fuligni, Lisa-Monique Edward, Nicholas Light, Mehdi Layeghifard, Ricardo Harripaul, Larissa Waldman, Bailey Gallinger, Federico Comitani, Ledia Brunga, Reid Hayes, Nathaniel D. Anderson, Arun K. Ramani, Kyoko E. Yuki, Sasha Blay, Brittney Johnstone, Cara Inglese, Rawan Hammad, Catherine Goudie, Andrew Shuen, Jonathan D. Wasserman, Rosemarie E. Venier, Marianne Eliou, Miranda Lorenti, Carol Ann Ryan, Michael Braga, Meagan Gloven-Brown, Jianan Han, Maria Montero, Famida Spatare, James A. Whitlock, Stephen W. Scherer, Kathy Chun, Martin J. Somerville, Cynthia Hawkins, Mohamed Abdelhaleem, Vijay Ramaswamy, Gino R. Somers, Lianna Kyriakopoulou, Johann Hitzler, Mary Shago, Daniel A. Morgenstern, Uri Tabori, Stephen Meyn, Meredith S. Irwin, David Malkin, Adam Shlien
Publikováno v:
Nature Cancer. 4:203-221
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-associated genes, complete genomes and transcriptomes for 300 mostly previously treated children and adolescents/young adults with cancer of poor prognosis or with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc564393b318b298215f3cddc8037c8
https://doi.org/10.1038/s43018-022-00474-y
https://doi.org/10.1038/s43018-022-00474-y
Autor:
Nathaniel D. Anderson, Sam Behjati
Publikováno v:
Immunity. 56:11-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63992d0c842fc936f36e0556372596b5
https://doi.org/10.1016/j.immuni.2022.12.016
https://doi.org/10.1016/j.immuni.2022.12.016
Autor:
Nathaniel D. Anderson
In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukaemia (R/R B-ALL), CD19 targeting CAR T-cells often induce durable remissions, which requires the persistence of CAR T-cells. Here, we systematically analysed CD19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394b235629c1591e21d7c29a61a1a2c6
Autor:
Albiruni R. Abdul Razak, Brendan C. Dickson, Adam Shlien, Kyaw L. Aung, Marcus O. Butler, Samer Salah, Uri Tabori, Jacalyn Kelly, Beatrice Y. Lau, Nathaniel D. Anderson, Scott Davidson, Jeremy Lewin
Mutational burden of tumor according to different subtypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b687eb78e75dee9ab7fb05072e7553
https://doi.org/10.1158/2326-6066.22539611
https://doi.org/10.1158/2326-6066.22539611
Autor:
Albiruni R. Abdul Razak, Brendan C. Dickson, Adam Shlien, Kyaw L. Aung, Marcus O. Butler, Samer Salah, Uri Tabori, Jacalyn Kelly, Beatrice Y. Lau, Nathaniel D. Anderson, Scott Davidson, Jeremy Lewin
Patient Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e27a879095fac7adc19f2c34862dd90
https://doi.org/10.1158/2326-6066.22539593
https://doi.org/10.1158/2326-6066.22539593