Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nathaniel Alzofon"'
Autor:
Stephan A. Ramos, Lucas H. Armitage, John J. Morton, Nathaniel Alzofon, Diana Handler, Geoffrey Kelly, Dirk Homann, Antonio Jimeno, Holger A. Russ
Publikováno v:
Stem Cell Reports. 18:829-840
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732fc4a76e437c872e5eb601e89f198a
https://doi.org/10.1016/j.stemcr.2023.02.013
https://doi.org/10.1016/j.stemcr.2023.02.013
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent MAML3 fusion genes in a subset of tumors that lacked known germline or somatic driver mutations and were associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::674750c2959d14a74db7c61f10663f20
https://doi.org/10.1158/1541-7786.c.6545123.v1
https://doi.org/10.1158/1541-7786.c.6545123.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
MAML3 overexpression has no effect on proliferation or apoptotic signaling. SK-N-SH, QGP-1 and BON-1 transfected with FL or dEx1 MAML3 and showed A) no increase in proliferation by BrdU assay when grown in full serum media for 72 hours and B) no incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce28523047fb39b8d33c486783b1d49
https://doi.org/10.1158/1541-7786.22526531.v1
https://doi.org/10.1158/1541-7786.22526531.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
MAML3 increases cell viability. SK-N-SH, QGP-1 and BON-1 transfected with FL or dEx1 MAML3 showed increased cell viability by Cell Titer Glo assay (* p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43eb7ceee271ddfe1b3e8b924d6642e
https://doi.org/10.1158/1541-7786.22526528
https://doi.org/10.1158/1541-7786.22526528
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
MAML3 in vitro cellular localization for QGP-1 and BON-1. Immunofluorescence of cells transfected with either FL or dEx1 MAML3 show nuclear localization of both constructs. FL MAML3 shows more punctate staining and dEx1 MAML3 shows more diffuse stain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819282a023f90d06f7de95657a526e1a
https://doi.org/10.1158/1541-7786.22526534
https://doi.org/10.1158/1541-7786.22526534
Autor:
Antonio Jimeno, Rene Gonzalez, Dennis R. Roop, William Robinson, Jing H. Wang, Xiao-Jing Wang, Theresa Medina, Hilary Somerset, Aik-Choon Tan, Dexiang Gao, Randi Yeager, Bettina Miller, Karina Gomez, Cera Nieto, Phuong N. Le, Loni Perrenoud, Julie Reisinger, Tugs-Saikhan Chimed, Stephen B. Keysar, Nathaniel Alzofon, J. Jason Morton
Resistance to immunotherapy is a significant challenge, and the scarcity of human models hinders the identification of the underlying mechanisms. To address this limitation, we constructed an autologous humanized mouse (aHM) model with hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655a6f1c1b66b2ca94647218902d75a6
https://doi.org/10.1158/1541-7786.c.6545108.v1
https://doi.org/10.1158/1541-7786.c.6545108.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
β-catenin interacts with dEx1 MAML3. Neuroendocrine tumor cell lines were co-transfected with β-catenin and dEx1 MAML3. Immunoprecipitation of MAML3 demonstrated co-precipitation of β-catenin in QGP-1 and BON-1, but not in SK-N-SH (not shown). B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636ec59d80d249412f1bb00e61adc8b0
https://doi.org/10.1158/1541-7786.22526519
https://doi.org/10.1158/1541-7786.22526519
Autor:
Antonio Jimeno, Rene Gonzalez, Dennis R. Roop, William Robinson, Jing H. Wang, Xiao-Jing Wang, Theresa Medina, Hilary Somerset, Aik-Choon Tan, Dexiang Gao, Randi Yeager, Bettina Miller, Karina Gomez, Cera Nieto, Phuong N. Le, Loni Perrenoud, Julie Reisinger, Tugs-Saikhan Chimed, Stephen B. Keysar, Nathaniel Alzofon, J. Jason Morton
Table S1. Expanded HSPC engraftment into mouse cohorts Table S2. Human immune cell presence in HM tissues Table S3a. CUHM003 mutations present at diagnosis b. Additional CUHM003 mutations present at progression c. CUHM005 mutations present at diagnos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c3fbcf5bdeea96081d6cb3e0e4b08c
https://doi.org/10.1158/1541-7786.22526474.v1
https://doi.org/10.1158/1541-7786.22526474.v1
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
β-catenin and FL or dEx1 MAML3 colocalize in the nucleus. Cell lines (A. SK-N-SH, B. QGP-1, C. BON-1) were co-transfected with either FL or dEx1 MAML3 and β-catenin or control plasmid. Cells overexpressing FL or dEx1 MAML3 alone showed some faint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bf0d22e47afbb8e57b06126fef87dd
https://doi.org/10.1158/1541-7786.22526522
https://doi.org/10.1158/1541-7786.22526522
Autor:
Lauren Fishbein, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Debbie L. Cohen, Katherine L. Nathanson, Christopher D. Raeburn, Maria Albuja-Cruz, Carrie B. Marshall, Nikita Pozdeyev, Kristin Panwell, Katrina Koc, Nathaniel Alzofon
C6 Oncogenic pathway analysis. GSEA of MAML3 dEx1 and FL transfected cells compared to control showed dysregulation of WNT and SHH signaling pathways. Filled circles represent an adjusted p value of less than 0.05, whereas empty circles represent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75844d521e93574da2ef9cbb51048e26
https://doi.org/10.1158/1541-7786.22526513.v1
https://doi.org/10.1158/1541-7786.22526513.v1