Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nathaniel A Hathaway"'
Autor:
Victoria J Madigan, Julianne A Yuziuk, Anna M Chiarella, Tyne O Tyson, Rita M Meganck, Zachary C Elmore, Longping V Tse, Nathaniel A Hathaway, Aravind Asokan
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007988 (2019)
Adeno-associated viruses (AAV) are Dependoparvoviruses that have shown promise as recombinant vectors for gene therapy. While infectious pathways of AAV are well studied, gaps remain in our understanding of host factors affecting vector genome expres
Externí odkaz:
https://doaj.org/article/fc7fbedd06ca440da188d4b61628143e
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0217699 (2019)
Durable gene silencing through the formation of compact heterochromatin domains plays a critical role during mammalian development in establishing defined tissues capable of retaining cellular identity. Hallmarks of heterochromatin gene repression ar
Externí odkaz:
https://doaj.org/article/bc19ce24ee1e468aac77467cc89694f1
Publikováno v:
Cells, Vol 12, Iss 2, p 325 (2023)
The expression of genetic information is tightly controlled by chromatin regulatory proteins, including those in the heterochromatin gene repression family. Many of these regulatory proteins work together on the chromatin substrate to precisely regul
Externí odkaz:
https://doaj.org/article/746866ebbdb8400fb1670ae637bf8282
Publikováno v:
Epigenetics, Vol 13, Iss 2, Pp 173-181 (2018)
Lsh is a chromatin remodeling factor that regulates DNA methylation and chromatin function in mammals. The dynamics of these chromatin changes and whether they are directly controlled by Lsh remain unclear. To understand the molecular mechanisms of L
Externí odkaz:
https://doaj.org/article/f0eda58b559340a0b4fdc6a575af760b
Autor:
Kathryn M. Headley, Katarzyna M. Kedziora, Aidin Alejo, Elianna Zhi-Xiang Lai, Jeremy E. Purvis, Nathaniel A. Hathaway
Publikováno v:
Stem Cell Research, Vol 38, Iss , Pp - (2019)
Here we utilized the chromatin in vivo assay (CiA) mouse platform to directly examine the epigenetic barriers impeding the activation of the CiA:Oct4 allele in mouse embryonic fibroblasts (MEF)s when stimulated with a transcription factor. The CiA:Oc
Externí odkaz:
https://doaj.org/article/32351aaaf3894319a827aa5bbfe3b5ad
Autor:
Xiaokang Yan, Michael R Williams, Ameriks D Barboza Castillo, Dmitri Kireev, Nathaniel A Hathaway
Publikováno v:
PNAS Nexus. 2
Gene regulation plays essential roles in all multicellular organisms, allowing for different specialized tissue types to be generated from a complex genome. Heterochromatin-driven gene repression, associated with a physical compaction of the genome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a7f71cf0431660f4a4d2ab82ecf4c29
https://doi.org/10.1093/pnasnexus/pgad062
https://doi.org/10.1093/pnasnexus/pgad062
Autor:
Dongbo Lu, Caroline A. Foley, Shama V. Birla, Austin J. Hepperla, Jeremy M. Simon, Lindsey I. James, Nathaniel A. Hathaway
Publikováno v:
ACS Synth Biol
CRISPR-Cas9 systems have been developed to regulate gene expression by using either fusions to epigenetic regulators or, more recently, through the use of chemically mediated strategies. These approaches have armed researchers with new tools to exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f131191e19babd90ec97027927d87704
https://doi.org/10.1021/acssynbio.1c00606
https://doi.org/10.1021/acssynbio.1c00606
Autor:
Kenneth H. Pearce, Sarah E. Clinkscales, Justin M. Rectenwald, Anna M. Chiarella, Jarod Waybright, Jacqueline Norris-Drouin, Kimberly D. Barnash, Gabrielle R Budziszewski, Laura E. Herring, Robert K. McGinty, Lindsey I. James, Stephanie H. Cholensky, Nathaniel A. Hathaway
Publikováno v:
ACS Chem Biol
The interpretation of histone post-translational modifications (PTMs), specifically lysine methylation, by specific classes of “reader” proteins marks an important aspect of epigenetic control of gene expression. Methyl-lysine (Kme) readers often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42dcca297c54496b9279ca2580b927
https://doi.org/10.1021/acschembio.1c00429
https://doi.org/10.1021/acschembio.1c00429
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding
Autor:
Xiaokang Yan, Jeanette Gowen Cook, Aleksandra Skrajna, Dennis Goldfarb, Emily H. Barbour, Robert K. McGinty, Nathaniel A. Hathaway, Katarzyna M. Kedziora, Emily M. Cousins, Nicholas G. Brown, Michael B. Major, Cathy J. Spangler, Gavin D. Grant
Publikováno v:
Nucleic Acids Research
Nuclear proteins bind chromatin to execute and regulate genome-templated processes. While studies of individual nucleosome interactions have suggested that an acidic patch on the nucleosome disk may be a common site for recruitment to chromatin, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5ea6c5d34fc55e0c451d1bf0933821
https://doi.org/10.1093/nar/gkaa544
https://doi.org/10.1093/nar/gkaa544
Autor:
Jian Jin, Dongbo Lu, Anna M. Chiarella, Xufen Yu, Silvia Pomella, Kyle V. Butler, Berkley E. Gryder, Nathaniel A. Hathaway, Tiffany A. Wang, Javed Khan
Publikováno v:
Nature biotechnology
Gene expression can be activated or suppressed using CRISPR–Cas9 systems. However, tools that enable dose-dependent activation of gene expression without the use of exogenous transcription regulatory proteins are lacking. Here we describe chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7659198c475b74db00d2132fb0b280
http://europepmc.org/articles/PMC6954327
http://europepmc.org/articles/PMC6954327