Výsledky vyhledávání - "Nathaniel, Barasa"

Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children

Autor: Nathaniel Barasa, Maisam Abu-El-Haija, Xinjian Wang, Nour Youssef, Tyler Thompson, C. Alexander Valencia, Lee A. Denson, Lindsey Hornung

Publikováno v: Pancreatology

Background/objectives Acute pancreatitis (AP) is emerging in pediatrics. A subset of children with AP progresses to acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). The role of extensive gene testing in the progression has not been i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f663c55f284b66b66db911c9d3eefce9
https://doi.org/10.1016/j.pan.2019.05.001

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The 253-kb inversion and deep intronic mutations inUNC13Dare present in North American patients with familial hemophagocytic lymphohistiocytosis 3

Autor: Diane Kissell, Alexandra H. Filipovich, Jessica A Connor, Nathaniel Barasa, Ammar Husami, Matthew T. Weirauch, C. Alexander Valencia, Yaping Qian, Kejian Zhang, Judith Johnson, Jeffery Schubert, Ge Zhang

Publikováno v: Pediatric Blood & Cancer. 61:1034-1040

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder due to dysregulation of the immune system.The predominant symptoms are persistent fever, cytopenias,hepatosplenomegaly, hepatitis, sometimes associated with hyper-ferritine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33c239fcb601dfcc98f0f016d21fc1eb
https://doi.org/10.1002/pbc.24955

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The 253-kb inversion and deep intronic mutations in UNC13D are present in North American patients with familial hemophagocytic lymphohistiocytosis 3

Autor: Yaping, Qian, Judith A, Johnson, Jessica A, Connor, C Alexander, Valencia, Nathaniel, Barasa, Jeffery, Schubert, Ammar, Husami, Diane, Kissell, Ge, Zhang, Matthew T, Weirauch, Alexandra H, Filipovich, Kejian, Zhang

Publikováno v: Pediatric bloodcancer. 61(6)

The mutations in UNC13D are responsible for familial hemophagocytic lymphohistiocytosis (FHL) type 3. A 253-kb inversion and two deep intronic mutations, c.118-308CT and c.118-307GA, in UNC13D were recently reported in European and Asian FHL3 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::389df51a5a6179bcd8d16df39b7c32d5
https://pubmed.ncbi.nlm.nih.gov/24616126

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IgG1 protects against renal disease in a mouse model of cryoglobulinaemia

Autor: Andrew B. Herr, Monir Hossain, David P. Witte, Jörg Köhl, Shiva Kumar Shanmukhappa, Chaim O. Jacob, Marat Khodoun, Ashley Mahler, Marc Ehlers, Keith F. Stringer, Nathaniel Barasa, Monica T. Posgai, Richard T. Strait, Fred D. Finkelman

Publikováno v: Nature

Here, the predominant murine immunoglobulin G subclass, IgG1, which is a poor activator of effector mechanisms, is shown to have a regulatory function, protecting against the development of IgG3 immune-complex-driven renal disease by competing with I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb268e5f0bbe484c68de6594570d168
https://pubmed.ncbi.nlm.nih.gov/26416751

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MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice

Autor: Nathaniel Barasa, Richard T. Strait, Nico van Rooijen, Wyenona Hicks, Marat Khodoun, Ashley Mahler, B. M. Susskind, David P. Witte, Jörg Köhl, Keith F. Stringer, Fred D. Finkelman

Publikováno v: Strait, R T, Hicks, W, Barasa, N, Mahler, A, Khodoun, M, Kohl, J, Stringer, K, Witte, D, van Rooijen, N, Susskind, B M & Finkelman, F D 2011, ' MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice ', Journal of Experimental Medicine, vol. 208, no. 12, pp. 2525-2544 . https://doi.org/10.1084/jem.20110159
Journal of Experimental Medicine, 208(12), 2525-2544. Rockefeller University Press
The Journal of Experimental Medicine

In a manner partially independent of activating Fcγ receptors, antibody-mediated production of complement component C5a and recruitment of macrophages elicit transfusion-related acute lung injury in mice.
Transfusion-related acute lung injury (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1ac9747fcc97a04abe98ad1f598a3b
https://research.vumc.nl/en/publications/f48bdf17-0a19-4db4-85b4-27563d9368c9

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IgG1 protects against IgG3 immune complex mediated renal disease. (176.21)

Autor: Richard Strait, Ashley Mahler, Nathaniel Barasa, Keith Stringer, David Witte, Andrew Herr, Fred Finkelman

Publikováno v: The Journal of Immunology. 188:176.21-176.21

Immunoglobulins (Ig) have been reported to inhibit or activate effector mechanisms with varying potency. In the mouse, IgG1 has less ability to activate complement (C), interact with stimulatory Fc receptors (FcRs) or form large immune complexes (IC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba96ca110153662f3a47d2200e0840c6
https://doi.org/10.4049/jimmunol.188.supp.176.21

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