Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nathanael Pruett"'
Autor:
Anand Singh, Nathanael Pruett, Shivani Dixit, Sudheer K. Gara, Haitao Wang, Roma Pahwa, David S. Schrump, Chuong D. Hoang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background Diffuse pleural mesothelioma (DPM) is an aggressive therapy-resistant cancer with unique molecular features. Numerous agents have been tested, but clinically effective ones remain elusive. Herein, we propose to use a small molecul
Externí odkaz:
https://doaj.org/article/22fc4d3729de4ebd8279bd47b42e0c46
Autor:
Meaghan Flagg, Kerry Goldin, Lizzette Pérez-Pérez, Manmeet Singh, Brandi N. Williamson, Nathanael Pruett, Chuong D. Hoang, Emmie de Wit
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
There is tremendous heterogeneity in the severity of COVID-19 disease in the human population, and the mechanisms governing the development of severe disease remain incompletely understood. The emergence of SARS-CoV-2 variants of concern (VOC) Delta
Externí odkaz:
https://doaj.org/article/ec540c177e954033983095d97fb37a3b
Autor:
Anand Singh, Nathanael Pruett, Roma Pahwa, Arushi P. Mahajan, David S. Schrump, Chuong D. Hoang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 669-681 (2021)
Malignant pleural mesothelioma (MPM) is an incurable surface neoplasm with peculiar pathobiology. MPM proliferates by using the tyrosine-kinase-Ras pathway. Despite representing an attractive therapeutic target, there are no standard agent(s) specifi
Externí odkaz:
https://doaj.org/article/61c858b8c4474f5d9fe4638fef37d247
Autor:
Li Zhang, Anand Singh, Christopher Plaisier, Nathanael Pruett, R. Taylor Ripley, David S. Schrump, Chuong D. Hoang
Publikováno v:
Translational Oncology, Vol 12, Iss 6, Pp 859-870 (2019)
Therapies against malignant pleural mesothelioma (MPM) have yielded disappointing results, in part, because pathologic mechanisms remain obscure. In searching for rational molecular targets, we identified metadherin (MTDH), a multifunctional gene ass
Externí odkaz:
https://doaj.org/article/3c940ff160d4425ca123e23db5f6596d
Autor:
Hirotaka Nakahashi, Kyong-Rim Kieffer Kwon, Wolfgang Resch, Laura Vian, Marei Dose, Diana Stavreva, Ofir Hakim, Nathanael Pruett, Steevenson Nelson, Arito Yamane, Jason Qian, Wendy Dubois, Scott Welsh, Robert D. Phair, B. Franklin Pugh, Victor Lobanenkov, Gordon L. Hager, Rafael Casellas
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1678-1689 (2013)
The “CTCF code” hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs). This model, however, is supported by in vitro binding studies of a limited nu
Externí odkaz:
https://doaj.org/article/8d3d3f59f89e43c5926c484dd8f1eb24
Publikováno v:
Expert Opin Drug Discov
INTRODUCTION: Mesothelioma is a rare, highly aggressive, incurable tumor arising from mesothelial linings in the body. Many drug therapies have been developed to treat this tumor including generalized chemotherapeutic agents, targeted molecular thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d9bc88c2582f38fde665fd1c326217
https://doi.org/10.1080/17460441.2021.1867530
https://doi.org/10.1080/17460441.2021.1867530
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Mesothelial cells are arranged as a monolayer on covering membranes that invest surfaces of body cavities like the pleura and peritoneum. Primary human mesothelial cell (HMC) cultures are needed for studying mesothelial cell homeostasis and developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d109c10a3c7b0d21229f6ad2049a155a
https://doi.org/10.1152/ajplung.00141.2020
https://doi.org/10.1152/ajplung.00141.2020
Autor:
Nisan Bhattacharyya, Abhishek K. Srivastava, Anand Singh, Chuong D. Hoang, R. Taylor Ripley, Nathanael Pruett, David S. Schrump
Publikováno v:
Mol Ther
Malignant pleural mesothelioma (MPM) is an incurable, aggressive neoplasm with distinctive features, including preservation of wild-type p53, irrespective of histologic subtype. We posited that this consistent molecular characteristic represents an u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37abaad3070b814dff50085b63c849b4
https://doi.org/10.1016/j.ymthe.2019.05.020
https://doi.org/10.1016/j.ymthe.2019.05.020
Autor:
Anand Singh, Nathanael Pruett, Roma Pahwa, Sudheer K. Gara, Shivani Dixit, Agnes Choi, David S. Schrump, Chuong D. Hoang
Publikováno v:
Cancer Research. 82:5470-5470
Introduction: Malignant pleural mesothelioma (MPM) is an aggressive incurable cancer usually associated with asbestos exposure. MPM has unique molecular features such as wild-type p53 (>90% regardless of histology) and aberrantly activated NF-κB. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85f17d96f085cc667e449fbee95051c
https://doi.org/10.1158/1538-7445.am2022-5470
https://doi.org/10.1158/1538-7445.am2022-5470
Autor:
Anand Singh, Arushi P. Mahajan, Nathanael Pruett, Chuong D. Hoang, Roma Pahwa, David S. Schrump
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 669-681 (2021)
Malignant pleural mesothelioma (MPM) is an incurable surface neoplasm with peculiar pathobiology. MPM proliferates by using the tyrosine-kinase-Ras pathway. Despite representing an attractive therapeutic target, there are no standard agent(s) specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8447f7ee57ab29d8be44c6727c664f31
https://pubmed.ncbi.nlm.nih.gov/33996251
https://pubmed.ncbi.nlm.nih.gov/33996251