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pro vyhledávání: '"Nathanael Laurent"'
Publikováno v:
Biochemical and Biophysical Research Communications. 278:414-418
Branched polyamines are extensively used as nonviral vectors for plasmid DNA in transfection experiments. Moreover, recently it has been shown that these compounds are able to eliminate prions from infected cells in cultures. It has been proposed tha
Publikováno v:
Biochemical and Biophysical Research Communications. 227:448-454
Plasmid 35S DNA, naked or associated with different cationic lipid preparations was injected to rats. Subcellular distribution of radioactivity in the liver one hour after injection, was established by centrifugation methods. Results show that at tha
Publikováno v:
Advanced drug delivery reviews. 41(2)
Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it has to travel through the intracellular endocytic pathway involving endosomes and lysosomes. However, some DNA molecules must escape these organelles to re
Autor:
Simone Wattiaux-De Coninck, Eugenie Mihaylova, Nathanael Laurent, Michel Jadot, Robert Wattiaux, Marie-Thérèse Warnier-Pirotte, Ekaterina Leontieva
Publikováno v:
FEBS letters. 443(1)
Efficiency of transfection is probably dependent on the rate of intracellular degradation of plasmid DNA. When a non-viral vector is used, it is not known to what extent the plasmid DNA catabolism is subordinated to the catabolism of the vector. In t