Výsledky vyhledávání - "Nathanael J Bangayan"

IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 21

Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe I soform peptides from R NA splicing for I mmunotherapy target S creening (IRIS), a computational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93609197fd5c544787a244456cbfc71
https://doi.org/10.1073/pnas.2221116120

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Akademický článek

MG-MLST: Characterizing the Microbiome at the Strain Level in Metagenomic Data

Autor: Nathanael J. Bangayan, Baochen Shi, Jerry Trinh, Emma Barnard, Gabriela Kasimatis, Emily Curd, Huiying Li

Publikováno v: Microorganisms, Vol 8, Iss 5, p 684 (2020)

The microbiome plays an important role in human physiology. The composition of the human microbiome has been described at the phylum, class, genus, and species levels, however, it is largely unknown at the strain level. The importance of strain-level

Externí odkaz: https://doaj.org/article/dfb4bb86c2584ce9800e15e5f76e76d5

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Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 31

Tissue-specific antigens can serve as targets for adoptive T cell transfer-based cancer immunotherapy. Recognition of tumor by T cells is mediated by interaction between peptide–major histocompatibility complexes (pMHCs) and T cell receptors (TCRs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39afba213dbd49e1152b82e74057d229
https://escholarship.org/uc/item/7k4312v2

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Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning

Autor: Zhiyuan Mao, John W. Phillips, Matthew B. Obusan, Donghui Cheng, Jami McLaughlin, Pavlo A Nesterenko, Nathanael J Bangayan, Christopher S. Seet, Yu Qin, Owen N. Witte, Giselle Burton Sojo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 3

T cell receptors (TCRs) are generated by somatic recombination of V/D/J segments to produce up to 1015 unique sequences. Highly sensitive and specific techniques are required to isolate and identify the rare TCR sequences that respond to antigens of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa4ba881e51ec0d3337556a0eec4b1a
https://escholarship.org/uc/item/1w24552c

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Abstract 2438: Determining the role of non-mutated C-Raf kinase in metastatic disease

Publikováno v: Cancer Research. 82:2438-2438

Many aggressive epithelial cancers do not carry targetable driver mutations (Mendiratta et al. 2021, NCI-MATCH Clinical trial NCT02465060). Commonly altered signaling pathways highlight the propensity for tumors to depend on such pathways for growth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1feb97a6c921245ae15af6d1a39698
https://doi.org/10.1158/1538-7445.am2022-2438

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Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling

Autor: Ashlea A. Morgan, Nathanael J. Bangayan, Panpan Yu, Herbert M. Geller, Yasuhiro Katagiri, Radoslaw Junka

Publikováno v: Journal of Biological Chemistry. 293:11639-11647

Receptor protein-tyrosine phosphatase RPTPσ has important functions in modulating neural development and regeneration. Compelling evidence suggests that both heparan sulfate (HS) and chondroitin sulfate (CS) glycosaminoglycans (GAGs) bind to a serie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dfa77463322ee8b196beface4954ba4
https://doi.org/10.1074/jbc.ra118.003081

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Rewiring T-cell responses to soluble factors with chimeric antigen receptors

Autor: Nathanael J Bangayan, Ximin Chen, Yvonne Y. Chen, ZeNan L. Chang, Uyen Tran, Michael H. Lorenzini

Publikováno v: Nature chemical biology

Chimeric antigen receptor (CAR)-expressing T cells targeting surface-bound tumor antigens have yielded promising clinical outcomes, with two CD19 CAR-T cell therapies recently receiving FDA approval for the treatment of B-cell malignancies. The adopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d960261ffcf5512495bab62c3a75ba4
https://doi.org/10.1038/nchembio.2565

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Correction: Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling

Autor: Yasuhiro Katagiri, Ashlea A. Morgan, Panpan Yu, Nathanael J. Bangayan, Radoslaw Junka, Herbert M. Geller

Publikováno v: The Journal of biological chemistry. 293(41)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20ae7d1fa63695f4818b1e1774d50b7
https://pubmed.ncbi.nlm.nih.gov/29880643

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