Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nathan Yumibe"'
Autor:
Daniel A. Briere, David B. Wainscott, José Miguel Minguez, Cynthia Stutsman, Qi Chen, Ana B. Bueno, Alma Jiménez, Kyle W. Sloop, Ana I. Mateo, Guemalli R. Cardona, Wenzhen Ma, Aaron D. Showalter, Graham R Cumming, Ana M. Castaño, Francis S. Willard, Richard W. Zink, Javier Agejas, Nathan Yumibe, Christopher M Corkins
Publikováno v:
Journal of Medicinal Chemistry. 64:3439-3448
The identification of LSN3318839, a positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R), is described. LSN3318839 increases the potency and efficacy of the weak metabolite GLP-1(9-36)NH2 to become a full agonist at the GLP-
Autor:
David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard
Publikováno v:
International Journal of Pharmacokinetics. 2:81-91
Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the P
Autor:
David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou
Publikováno v:
Drug Metabolism and Disposition. 44:1184-1192
The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic changes resemble human type 2 diabetes associated with obesity a
Autor:
Steven D. Kahl, Kelly L. Wilbur, Warshawsky Alan M, Jayana Pankaj Lineswala, Siddaramaiah Cr, Pranab Maiti, Sweetana Stephanie Ann, Diseroad Benjamin Alan, Lisa A. Adams, Yanyun Chen, Richard W. Zink, Anne Reifel Miller, Grace L. Neathery, Anjana Patel Lewis, Over Cabrera, Alison N. Campbell, Guemalli R. Cardona, Nathan Yumibe, Keyue Chen, Keith A. Otto, Cecilia Bouaichi, Xiaosu Ma, Chafiq Hamdouchi, Amy C. DeBaillie, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 61(3)
As a part of our program to identify potent GPR40 agonists capable of being dosed orally once daily in humans, we incorporated fused heterocycles into our recently disclosed spiropiperidine and tetrahydroquinoline acid derivatives 1, 2, and 3 with th
Autor:
Anne Reifel Miller, Marialuisa C. Marcelo, Qi Chen, Ruth Belin, Pranab Maiti, Joseph V. Haas, Jared L. Piper, Ellen A. Cannady, Steven D. Kahl, Anjana Patel Lewis, Guemalli R. Cardona, Jason T. Johnson, D. Scott Coffey, Dawn A. Brooks, James Ficorilli, Xiaosu Ma, Sweetana Stephanie Ann, Chafiq Hamdouchi, Yanyun Chen, Edward J. Pratt, Keyue Chen, Richard W. Zink, Kelly L. Wilbur, Keith A. Otto, Mark A. Deeg, Nathan Yumibe, Jayana Pankaj Lineswala, Thomas E Eessalu, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 59(24)
The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence
Autor:
Yanping Xu, Nathan Bryan Mantlo, Fatima Iradier, Leonard L. Winneroski, Gary J. Etgen, Chahrzad Montrose-Rafizadeh, Carol L. Broderick, Jason Eric Lamar, Nathan Yumibe, Richard W. Zink, Brian A. Oldham, Jeremy Schulenburg York, Isabel C. Gonzalez
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1052-1055
The design and synthesis of dual PPAR γ/δ agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZD
Autor:
Warshawsky Alan M, Chahrzad Montrose-Rafizadeh, Henry James Robert, Rose T. Ajamie, Viswanath Devanarayan, Nathan Yumibe, Elizabeth A. Misener, Richard W. Zink, Daniel A. Briere, Yihong Li, Eric D. Hawkins, Joseph T. Brozinick, Brad Wilken
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6293-6297
Novel tetrahydroisoquinolines have been developed as potent PPAR ligands. Evaluation of these compounds in PPARgamma responsive models of type 2 diabetes is described.
Autor:
Q. May Wang, John I. Glass, Yip Yvonne Yee Mai, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Robert B. Johnson, Nancy June Snyder, Guo Deqi, Jason Eric Lamar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:257-261
With the aim of discovering potent and selective HCV protease inhibitors, we synthesized and evaluated a series of 1a based tetrapeptidyl ketoamides with additional modification(s) at P1′, P1, and P3 positions. As a result of this effort, we found
Autor:
Jason Eric Lamar, Ling Jin, Daryl Venable, Lifei Liu, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Q. May Wang, Yip Yvonne Yee Mai, Donna Barket, Robert B. Johnson, Joe Colacino, Mark Wakulchik, John E. Munroe, Beverly A. Heinz, John I. Glass, Congping Xie, Elcira C. Villarreal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:251-256
We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.
Autor:
Amy L. Cox, Gregory T. Knipp, Robyn R. McCain, Kenneth J. Ruterbories, Cheng Cai Tang, Xin Zhang, Nathan Yumibe, Rajesh Kulkarni, Zhongyi Wang
Publikováno v:
Journal of pharmaceutical sciences. 101(11)
The utility of pigs as preclinical animals for pharmaceutical development was assessed by evaluating the pharmacokinetics and pharmacodynamics of glipizide (Glucotrol®) following oral administration of immediate-release (IR) and modified-release (MR