Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nathan Trim"'
Publikováno v:
In Hepatology 2001 34(4) Part 2:A340-A340
Autor:
Nathan Trim, John P. Iredale, James Chan, Andrew Nash, Xiaoying Zhou, Aqeel Jamil, R. Christopher Benyon
Publikováno v:
Journal of Biological Chemistry. 281:39757-39765
Myofibroblastic-activated hepatic stellate cells are the major source of the collagen I-rich extracellular matrix in liver fibrosis but also produce matrix metalloproteinases, which remodel this protein. We have investigated the role of collagen I pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07dc5eab581e9b63c1216d7b7176839
https://doi.org/10.1074/jbc.m605621200
https://doi.org/10.1074/jbc.m605621200
Autor:
John P. Iredale, Christothea M. Constandinou, Kenneth J. Hillan, Derek A. Mann, R. Christopher Benyon, Timothy J. Kendall, Fiona Oakley, Nathan Trim, Alane M. Gray, Gretchen Frantz, Weilan Ye
Publikováno v:
The American Journal of Pathology. 163:1849-1858
A key feature of recovery from liver fibrosis is hepatic stellate cell (HSC) apoptosis, which serves the dual function of removing the major source of neomatrix and tissue inhibitors of metalloproteinases thereby facilitating matrix degradation. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89278a09fe23a6fa50adc8a2ff8ff2d4
https://doi.org/10.1016/s0002-9440(10)63544-4
https://doi.org/10.1016/s0002-9440(10)63544-4
Autor:
Elizabeth J. Williams, B H Grove, RC Benyon, John P. Iredale, E N Unemori, Michael J. P. Arthur, R Hadwin, Nathan Trim
Publikováno v:
Gut. 49:577-583
BACKGROUND—Following liver injury, hepatic stellate cells (HSC) transform into myofibroblast-like cells (activation) and are the major source of type I collagen and the potent collagenase inhibitors tissue inhibitors of metalloproteinases 1 and 2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceba680f1a2659eb68b134c842c5643
https://doi.org/10.1136/gut.49.4.577
https://doi.org/10.1136/gut.49.4.577
Publikováno v:
Molecular and Biochemical Parasitology. 93:263-271
AF3 (AVPGVLRFamide) is an endogenous RFamide-like peptide isolated from the parasitic nematode Ascaris suum. It has a potent and long lasting excitatory effect in A. suum and Ascaridia galli. This is mediated by a mechanism independent of the nicotin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2f3cdfefbc36f67349d682cd5b7abd
https://doi.org/10.1016/s0166-6851(98)00039-5
https://doi.org/10.1016/s0166-6851(98)00039-5
Autor:
Nathan Trim, John P. Iredale, Xiaoying Zhou, Razao Issa, Christopher Benyon, Harry Millward-Sadler, Stephen M. Krane
Publikováno v:
The FASEB Journal. 17:47-49
Collagen-I, which predominates in the neomatrix of fibrotic liver, regulates hepatocyte and hepatic stellate cell (HSC) phenotypes. Recovery from liver fibrosis is accompanied by hepatocyte regeneration, matrix degradation, and HSC apoptosis. Using m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8288c79e4f37100481651f22d2015f
https://doi.org/10.1096/fj.02-0494fje
https://doi.org/10.1096/fj.02-0494fje
Autor:
Xiaoying, Zhou, Aqeel, Jamil, Andrew, Nash, James, Chan, Nathan, Trim, John P, Iredale, R Christopher, Benyon
Publikováno v:
The Journal of biological chemistry. 281(52)
Myofibroblastic-activated hepatic stellate cells are the major source of the collagen I-rich extracellular matrix in liver fibrosis but also produce matrix metalloproteinases, which remodel this protein. We have investigated the role of collagen I pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33a8be8f7497e866c1cf33f0568d1869
https://pubmed.ncbi.nlm.nih.gov/17060319
https://pubmed.ncbi.nlm.nih.gov/17060319
Autor:
Jonathan A. Fallowfield, Emma Sands, Andreas Knorr, Xiaoying Zhou, R. Christopher Benyon, Michael J. P. Arthur, Marianna D. A. Gaça, Nathan Trim, John P. Iredale, Christothea M. Constandinou, Ibnauf Suliman, Razao Issa, Harry Millward-Sadler
Publikováno v:
Gastroenterology. 126(7)
Background & Aims: Liver fibrosis and cirrhosis result from the excessive secretion of matrix proteins by hepatic stellate cells (HSCs). Previously considered irreversible, we have studied a model of cirrhosis to determine the mechanisms mediating an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45666739212ee371e530d269d7ba11f9
https://pubmed.ncbi.nlm.nih.gov/15188175
https://pubmed.ncbi.nlm.nih.gov/15188175
Autor:
Razao, Issa, Xiaoying, Zhou, Nathan, Trim, Harry, Millward-Sadler, Stephen, Krane, Christopher, Benyon, John, Iredale
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(1)
Collagen-I, which predominates in the neomatrix of fibrotic liver, regulates hepatocyte and hepatic stellate cell (HSC) phenotypes. Recovery from liver fibrosis is accompanied by hepatocyte regeneration, matrix degradation, and HSC apoptosis. Using m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a861bcfdc01cac55f7a167d5c1152afd
https://pubmed.ncbi.nlm.nih.gov/12475903
https://pubmed.ncbi.nlm.nih.gov/12475903
Autor:
John P. Iredale, Michael J. P. Arthur, Razo Issa, John N. Primrose, Nathan Trim, Matthew C. Wright, Derek A. Mann, David E. Smart, Graeme I. Murray
Publikováno v:
Gastroenterology. 121(3)
Background & Aims: Hepatic stellate cells (HSCs) play a pivotal role in liver fibrosis and stimulating their apoptosis could be an effective treatment for liver fibrosis. Methods: Activated HSCs, hepatocytes, and rats with liver fibrosis were treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a902b7126cdd9415a85519a1cf37e0f8
https://pubmed.ncbi.nlm.nih.gov/11522753
https://pubmed.ncbi.nlm.nih.gov/11522753