Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nathan T. Ihle"'
Autor:
Catherine Lee, Ziyue Karen Jiang, Simon Planken, Lisa K. Manzuk, Roberto Ortiz, Michael Hall, Kavon Noorbehesht, Sripad Ram, Timothy Affolter, Gabriel E. Troche, Nathan T. Ihle, Theodore Johnson, Youngwook Ahn, Manfred Kraus, Anand Giddabasappa
Publikováno v:
Molecular Cancer Therapeutics.
KRAS is one of the most commonly mutated oncogenes in lung, colorectal, and pancreatic cancers. Recent clinical trials directly targeting KRAS G12C presented encouraging results for a large population of non-small cell lung cancer (NSCLC), but resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b7ef6aaafa7f1fc7310d35581ada2ee
https://doi.org/10.1158/1535-7163.mct-22-0810
https://doi.org/10.1158/1535-7163.mct-22-0810
Autor:
Garth Powis, Lynn Kirkpatrick, Robert C. Liddington, Laurie A. Bankston, Ricardo G. Correa, Fabiana I.A.L. Layng, Lei Du-Cuny, Robert Lemos, Shuxing Zhang, Emmanuelle J. Meuillet, Zamal Ahmed, Michael Scott, Geoffrey Grandjean, Nathan T. Ihle, Marco Maruggi, Roisin Puentes, Martin Indarte
An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors Supplemental Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4049decc5165ea5a5548638457e6315
https://doi.org/10.1158/0008-5472.22421073
https://doi.org/10.1158/0008-5472.22421073
Autor:
Garth Powis, Lynn Kirkpatrick, Robert C. Liddington, Laurie A. Bankston, Ricardo G. Correa, Fabiana I.A.L. Layng, Lei Du-Cuny, Robert Lemos, Shuxing Zhang, Emmanuelle J. Meuillet, Zamal Ahmed, Michael Scott, Geoffrey Grandjean, Nathan T. Ihle, Marco Maruggi, Roisin Puentes, Martin Indarte
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain–containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570ccd2ee8215290557b6c0ec2d39371
https://doi.org/10.1158/0008-5472.c.6510828.v1
https://doi.org/10.1158/0008-5472.c.6510828.v1
Autor:
Ricardo G. Correa, Nathan T. Ihle, Laurie A. Bankston, Robert Lemos, Lynn Kirkpatrick, Michael J. Scott, Shuxing Zhang, Robert C. Liddington, Martin Indarte, Fabiana I.A.L. Layng, Garth Powis, Geoffrey Grandjean, Zamal Ahmed, Lei Du-Cuny, Emmanuelle J. Meuillet, Roisin Puentes, Marco Maruggi
Publikováno v:
Cancer Res
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain-containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c4b1cc628c0b53bf009b240b2162a1
https://pubmed.ncbi.nlm.nih.gov/31040156
https://pubmed.ncbi.nlm.nih.gov/31040156
Autor:
Ricardo G. Correa, Roisin Puentes, Nathan T. Ihle, Fabiana I.A.L. Layng, Robert Lemos, Mike Scott, Marco Maruggi, Lei Du-Cuny, Garth Powis, Laurie A. Bankston, Robert C. Liddington, Zamal Ahmed, Martin Indarte, Lynn Kirkpatrick, Emmanuelle J. Meuillet, Geoffrey Grandjean, Shuxing Zang
Publikováno v:
Cancer research. 79(12)
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain–containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf247d096d80bb6b6446e9263018847
https://pubmed.ncbi.nlm.nih.gov/31615811
https://pubmed.ncbi.nlm.nih.gov/31615811
Autor:
Roy S. Herbst, Edward S. Kim, Mena Abdelmelek, Ximing Tang, Lauren Averett Byers, Ignacio I. Wistuba, Waun Ki Hong, George R. Blumenschein, Jing Wang, Vassiliki A. Papadimitrakopoulou, John D. Minna, Lu Chen, Lixia Diao, Jill E. Larsen, Anne Tsao, Pierre Saintigny, Kevin R. Coombes, Scott M. Lippman, Garth Powis, Suyu Liu, Nathan T. Ihle, J. Jack Lee, Shuxing Zhang, John V. Heymach
Publikováno v:
JNCI: Journal of the National Cancer Institute. 104:228-239
Background Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) play a critical role in cancer cell growth and resistance to therapy. Most mutations occur at codons 12 and 13. In colorectal cancer, the presence of any mutant K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16f31b120730c96e720128fc4159753
https://doi.org/10.1093/jnci/djr523
https://doi.org/10.1093/jnci/djr523
Autor:
Robert T. Abraham, Nathan T. Ihle
Publikováno v:
Molecular Cell. 65:959-960
The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson's disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93617d6ffb627f6277ae6deede44eacf
https://doi.org/10.1016/j.molcel.2017.02.030
https://doi.org/10.1016/j.molcel.2017.02.030
Publikováno v:
Current Cancer Drug Targets. 11:190-198
Despite recent successes, metastatic colorectal cancer remains a difficult cancer to treat. Since the initial discovery that PI-3-Kinase/AKT signaling played an important part in the growth and survival of colorectal tumors, preclinical studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09703cbe622eef3052ec4768c9aa9961
https://doi.org/10.2174/156800911794328448
https://doi.org/10.2174/156800911794328448
Autor:
Garth Powis, Eugene A. Mash, Emmanuelle J. Meuillet, Ali M. Ahad, John Kingston, Lei Du-Cuny, Robert Lemos, Nathan T. Ihle, Shuxing Zhang, D. Lynn Kirkpatrick, Jörg J. Jacoby, Li Li Zhou, Sylvestor A. Moses, Song Zuohe, Ryan Watkins, Roy S. Herbst
Publikováno v:
Molecular Cancer Therapeutics. 9:706-717
Phosphatidylinositol 3-kinase/phosphatidylinositide-dependent protein kinase 1 (PDPK1)/Akt signaling plays a critical role in activating proliferation and survival pathways within cancer cells. We report the molecular pharmacology and antitumor activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4db7ac75e0b8051aba3d0bb92a736c3
https://doi.org/10.1158/1535-7163.mct-09-0985
https://doi.org/10.1158/1535-7163.mct-09-0985
Autor:
Garth Powis, Nathan T. Ihle
Publikováno v:
Molecular Cancer Therapeutics. 8:1-9
The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is currently one of the most exciting drug targets in oncology. However, only a short time ago, the paradigm existed that drugs targeted to the four PI3K class I isoforms would be too tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d918c79c67dad2375aa8386833cec2a1
https://doi.org/10.1158/1535-7163.mct-08-0801
https://doi.org/10.1158/1535-7163.mct-08-0801