Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Nathan T Jacobs"'
Autor:
Brenda M Calderon, Shamika Danzy, Gabrielle K Delima, Nathan T Jacobs, Ketaki Ganti, Megan R Hockman, Graeme L Conn, Anice C Lowen, John Steel
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007892 (2019)
The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the underlying mechanisms, we examined a panel of
Externí odkaz:
https://doaj.org/article/8d1b51a008484550be7fee121c465810
Autor:
Caline G Matar, Neil R Anthony, Brigid M O'Flaherty, Nathan T Jacobs, Lalita Priyamvada, Christian R Engwerda, Samuel H Speck, Tracey J Lamb
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004858 (2015)
Immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for Plasmodium falciparum. Yet, nearly 20% of infected children die annually as a result of severe malaria. Multiple risk factors are
Externí odkaz:
https://doaj.org/article/651d93814d444d15a59ad9edbf5b1bb4
Autor:
Surya D. Aggarwal, John A. Lees, Nathan T. Jacobs, Gavyn Chern Wei Bee, Annie R. Abruzzo, Jeffrey N. Weiser
SUMMARYChromosomal barcoding and high-throughput sequencing were used to investigate the population dynamics of Streptococcus pneumoniae. During infant mouse colonization, >35-fold reduction in diversity and expansion of a single clonal lineage was o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39484fa20b4b6e5dd10c36bf1ce8e552
https://doi.org/10.1101/2022.08.05.500807
https://doi.org/10.1101/2022.08.05.500807
Autor:
Gene S. Tan, Silvia Carnaccini, Maria C. White, Anice C. Lowen, Lucas M. Ferreri, Ketaki Ganti, Brett E. Pickett, Kara L. Phipps, Miglena Manandhar, Daniel R. Perez, Chung-Young Lee, Nathan T. Jacobs
Publikováno v:
Nature microbiology
Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Here, we exploit both single-cell approaches and whole-animal systems to show that IAV reliance on multiple infection can form an important sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf0c8be253d92ea8cde7b3c6b499d27
http://europepmc.org/articles/PMC7484227
http://europepmc.org/articles/PMC7484227
Publikováno v:
J Virol
Segmentation of viral genomes provides the potential for genetic exchange within coinfected cells. However, for this potential to be realized, coinfecting genomes must mix during the viral life cycle. The efficiency of reassortment, in turn, dictates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a34068bcd7a50edd83296e41b61f77
https://pubmed.ncbi.nlm.nih.gov/34935439
https://pubmed.ncbi.nlm.nih.gov/34935439
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Segmentation of viral genomes into multiple RNAs creates the potential for replication of incomplete viral genomes (IVGs). Here we use a single-cell approach to quantify influenza A virus IVGs and examine their fitness implications. We find that each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a9676b8cb615a4bbf55a72f3570f43
http://link.springer.com/article/10.1038/s41467-019-11428-x
http://link.springer.com/article/10.1038/s41467-019-11428-x
Autor:
John Steel, Brenda M. Calderon, Ketaki Ganti, Shamika Danzy, Nathan T. Jacobs, Megan R. Hockman, Graeme L. Conn, Anice C. Lowen, Gabrielle K. Delima
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 8, p e1007892 (2019)
PLoS Pathogens, Vol 15, Iss 8, p e1007892 (2019)
The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the underlying mechanisms, we examined a panel of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16147d5d24e98b9592f77703917d4b25
http://europepmc.org/articles/PMC6695095
http://europepmc.org/articles/PMC6695095
Viral genomes comprising multiple distinct RNA segments can undergo genetic exchange through reassortment, a process that facilitates viral evolution and can have major epidemiological consequences. Segmentation also allows the replication of incompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1edc0f1edf602b2557cc198ac3f7d1b
Autor:
Brent L. Showalter, Edward J. Vresilovic, Daniel H. Cortes, John F. DeLucca, Dawn M. Elliott, John M. Peloquin, Jonathon H. Yoder, James C. Gee, Nathan T. Jacobs, Alexander C. Wright
Publikováno v:
Journal of Orthopaedic Research. 34:1264-1273
Tissue strain is an important indicator of mechanical function, but is difficult to noninvasively measure in the intervertebral disc. The objective of this study was to generate a disc strain template, a 3D average of disc strain, of a group of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2c5b3c68e28502e9d28f3c4c972f5a
https://doi.org/10.1002/jor.23137
https://doi.org/10.1002/jor.23137
Publikováno v:
Journal of Virology, 92(5):UNSP e02063-17. American Society for Microbiology
Journal of Virology
Journal of Virology
Exchange of gene segments through reassortment is a major feature of influenza A virus evolution and frequently contributes to the emergence of novel epidemic, pandemic, and zoonotic strains. It has long been evident that viral diversification throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc35aa97589faf3e18b65e6df827aaa
https://doi.org/10.1128/jvi.02063-17
https://doi.org/10.1128/jvi.02063-17