Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nathan Robertson"'
Autor:
Michael Mullin, James McClory, Winston Haynes, Justin Grace, Nathan Robertson, Gino van Heeke
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTThe development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic. These
Externí odkaz:
https://doaj.org/article/01baed59c39a4b3285f77233b47c5e3e
Publikováno v:
Native Plants Journal. 24:54-60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86577496dd17ff49b634de53d5cf6bc
https://doi.org/10.3368/npj.24.1.54
https://doi.org/10.3368/npj.24.1.54
Autor:
Payne Thomas Augustus, Nancy López-Antón, Hena Khalique, Siobhan Clerkin, Vaughan R. Leydon, Tim D Jones, Len Seymour, Alexander Raeside, Zainab Khalaf, Nathan Robertson, Shalom A. Gurjar, Richard P. Parker-Manuel, Ryan Cawood
Publikováno v:
The Journal of Biological Chemistry
Reliable, specific polyclonal and monoclonal antibodies are important tools in research and medicine. However, the discovery of antibodies against their targets in their native forms is difficult. Here, we present a novel method for discovery of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1432fa6082acd880b9b3119d18eac3
http://europepmc.org/articles/PMC7939478
http://europepmc.org/articles/PMC7939478
Publikováno v:
2022 Intermountain Engineering, Technology and Computing (IETC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7dc9d8df956955130f1f98b2589b685
https://doi.org/10.1109/ietc54973.2022.9796891
https://doi.org/10.1109/ietc54973.2022.9796891
Autor:
Andrew B. Tobin, Gerard R. Dawson, Patrick M. Sexton, Nathan Robertson, Sophie J. Bradley, Francesca Perini, Arthur Christopoulos, James C. Errey, Barry John Teobald, John Francis William Deakin, Lisa M. Broad, Jan Liptrot, Christopher J. Langmead, K.A. Bennett, Mary Vinson, Pradeep J. Nathan, Colin Molloy, Robert M. Cooke, Edward Hurrell, Michael Browning, Krzysztof Okrasa, Jason M Brown, Giulio Mattedi, Alastair J. H. Brown, David M. Cross, Greg J. Osborne, Julie E. Cansfield, Ali Jazayeri, Christoffer Bundgaard, Stephen R. Morairty, J.C. Patel, Fiona H. Marshall, Brian D. Hudson, Prakash Rucktooa, Robert T. Smith, Keith G. Phillips, Louis Dwomoh, Chris de Graaf, Malcolm Peter Weir, Julie Warneck, Giles A. Brown, Mark Pickworth, Benjamin G. Tehan, Tim Tasker, Anushka V. Goonawardena, Miles Congreve, João M. Dias, Shahram Shahabi
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b008b7a3c01abe25b8e63fdab465cc4
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
Autor:
Sangbae Lee, Nagarajan Vaidehi, Nathan Robertson, Suvamay Jana, Christopher G. Tate, Soumadwip Ghosh
Publikováno v:
Biochemistry
The structural and functional properties of G protein-coupled receptors (GPCRs) are often studied in a detergent micellar environment, but many GPCRs tend to denature or aggregate in short alkyl chain detergents. In our previous work [Lee, S., et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59462c6311fdd070a1783984e68ac9ef
http://europepmc.org/articles/PMC7302508
http://europepmc.org/articles/PMC7302508
Autor:
Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin
Publikováno v:
Trends Pharmacol Sci
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279
https://pubmed.ncbi.nlm.nih.gov/35101279
Publikováno v:
WIREs Computational Statistics. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9a723f91086e14c0f710acb00b82807
https://doi.org/10.1002/wics.1501
https://doi.org/10.1002/wics.1501
Autor:
Alastair J. H. Brown, Sophie J. Bradley, Giles A. Brown, Kirstie A. Bennett, Jason Brown, Julie E. Cansfield, David M. Cross, João M. Dias, James C. Errey, Edward Hurrell, Jan Liptrot, Colin Molloy, Pradeep J. Nathan, Krzysztof Okrasa, Greg Osbourne, Jayesh C. Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M. Broad, Anushka V. Goonawardena, Stephen R. Morairty, Michael Browning, Francesca Perini, Gerard R. Dawson, John F. W. Deakin, Robert T. Smith, Patrick M. Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G. Tehan, Barry Teobald, Arthur Christopoulos, Christopher J. Langmead, Ali Jazayeri, Robert M. Cooke, Fiona H. Marshall, Prakash Rucktooa, Miles S. Congreve, Malcolm Weir, Andrew Tobin
Publikováno v:
SSRN Electronic Journal.
Current therapies for improving memory in Alzheimer’s disease are focused on correcting for defective cholinergic transmission by increasing acetylcholine levels through inhibition of acetylcholinesterase enzymes. These treatments are however assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9223ad5ca22fdc8ece3f25838d310314
https://doi.org/10.2139/ssrn.3641933
https://doi.org/10.2139/ssrn.3641933
Monte Carlo experiments produce samples in order to estimate features of a given distribution. However, simultaneous estimation of means and quantiles has received little attention, despite being common practice. In this setting we establish a multiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2985721a91bfdd827ac86f4bf1bd448e