Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Nathan R West"'
1
Akademický článek
Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma.
Autor: Katelin N Townsend, Jaeline E Spowart, Hassan Huwait, Sima Eshragh, Nathan R West, Mary A Elrick, Steve E Kalloger, Michael Anglesio, Peter H Watson, David G Huntsman, Julian J Lum
Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82406 (2013)
When T cells infiltrate the tumor environment they encounter a myriad of metabolic stressors including hypoxia. Overcoming the limitations imposed by an inadequate tumor vasculature that contributes to these stressors may be a crucial step to immune
Externí odkaz: https://doaj.org/article/25328a1534014adf872b302f8c1577c3
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2
Akademický článek
Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women
Autor: Nathan R. West, James Dorling, Alice E. Thackray, Nicola C. Hanson, Samantha E. Decombel, David J. Stensel, Stuart J. Grice
Publikováno v: Journal of Obesity, Vol 2018 (2018)
Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns
Externí odkaz: https://doaj.org/article/8c72f59803064a78a71220b93c904b9e
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4
Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women
Autor: Stuart F. J. Le Grice, Nathan R. West, Samantha E. Decombel, Alice E. Thackray, Nicola C. Hanson, James L. Dorling, David J. Stensel
Publikováno v: Journal of Obesity, Vol 2018 (2018)
Journal of Obesity
Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92226bb7be600478a1a754bcd427874f
https://doi.org/10.1155/2018/7560707
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5
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer
Autor: Enric Domingo, Lucy C. Garner, Matthias Friedrich, David Barras, Nathan R. West, Sabine Tejpar, Mauro Delorenzi, Elizabeth H. Mann, Tim Maughan, Fiona Powrie, Alina Janney, Samuel J. Bullers, Sarah McCuaig, Viktor H. Koelzer
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 26(16)
Purpose:The cytokine IL22 promotes tumor progression in murine models of colorectal cancer. However, the clinical significance of IL22 in human colorectal cancer remains unclear. We sought to determine whether the IL22 pathway is associated with prog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d788aa16eb7a1864b541c04858ab7e2e
https://pubmed.ncbi.nlm.nih.gov/32430479
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6
Coordination of Immune-Stroma Crosstalk by IL-6 Family Cytokines
Autor: Nathan R. West
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Stromal cells are a subject of rapidly growing immunological interest based on their ability to influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue, stromal cells complement the functions of classical immun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cbe9d15141b28eb9d92ae2b35f2d03
https://pubmed.ncbi.nlm.nih.gov/31156640
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7
Gut microbiota induce local and systemic CD4 T cell responses in healthy individuals that are altered in inflammatory bowel diseases
Autor: Fiona Powrie, Holm H. Uhlig, Satish Keshav, K Suijker, Mjt Stubbington, Bmj Owens, Andreas Bergthaler, Andrew J. McMichael, Sarah A. Teichmann, A. Datsi, Ahmed N. Hegazy, Nathan R. West, Emily Wendt, Sylvia H. Duncan, Camille Danne, Suzanne Campion, S This
Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie – 11. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ef4e1b38fa087b96dea40987ce3691a
https://doi.org/10.1055/s-0037-1604874
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9
Immunotherapy Not Working? Check Your Microbiota
Autor: Fiona Powrie, Nathan R. West
Publikováno v: Cancer Cell. 28(6):687-689
T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood. One possible modulator could be the intestinal microbiota. We comp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c64485c5a506877f90b4c1dafca163
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10
Model-directed engineering of 'difficult-to-express' monoclonal antibody production by Chinese hamster ovary cells
Autor: Ray Field, David C. James, Stephen J. Wilkinson, Nathan R. West, Greg Dean, Andrew Smith, Olalekan Daramola, Leon P. Pybus
Publikováno v: Biotechnology and Bioengineering. 111:372-385
Despite improvements in volumetric titer for monoclonal antibody (MAb) production processes using Chinese hamster ovary (CHO) cells, some "difficult-to-express" (DTE) MAbs inexplicably reach much lower process titers. These DTE MAbs require intensive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b18adfd186021eefb36cafd627628416
https://doi.org/10.1002/bit.25116
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