Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nathan R Qi"'
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0223340 (2020)
The Rab GTPase activating protein known as Akt substrate of 160 kDa (AS160 or TBC1D4) regulates insulin-stimulated glucose uptake in skeletal muscle, the heart, and white adipose tissue (WAT). A novel rat AS160-knockout (AS160-KO) was created with CR
Externí odkaz:
https://doaj.org/article/288efa1091824d848c062b266f080790
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1005982 (2018)
High capacity and low capacity running rats, HCR and LCR respectively, have been bred to represent two extremes of running endurance and have recently demonstrated disparities in fuel usage during transient aerobic exercise. HCR rats can maintain fat
Externí odkaz:
https://doaj.org/article/5c768d979759462c826992f0d2602344
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117232 (2015)
A critical application of metabolomics is the evaluation of tissues, which are often the primary sites of metabolic dysregulation in disease. Laboratory rodents have been widely used for metabolomics studies involving tissues due to their facile hand
Externí odkaz:
https://doaj.org/article/a0e8e81ff1954734a38266a04029e618
Autor:
Naveen Sharma, Donel A Sequea, Carlos M Castorena, Edward B Arias, Nathan R Qi, Gregory D Cartee
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65118 (2014)
Calorie restriction (CR) (consuming ~60% of ad libitum, AL, intake) improves whole body insulin sensitivity and enhances insulin-stimulated glucose uptake by isolated skeletal muscles. However, little is known about CR-effects on in vivo glucose upta
Externí odkaz:
https://doaj.org/article/e63eef2ec5154f4f8e388bc59579aa7b
Autor:
Yu-Yu Ren, Katherine A Overmyer, Nathan R Qi, Mary K Treutelaar, Lori Heckenkamp, Molly Kalahar, Lauren G Koch, Steven L Britton, Charles F Burant, Jun Z Li
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77588 (2013)
Aerobic capacity is a strong predictor of all-cause mortality and can influence many complex traits. To explore the biological basis underlying this connection, we developed via artificial selection two rat lines that diverge for intrinsic (i.e. inbo
Externí odkaz:
https://doaj.org/article/7b2375c877494977b4e0e82e43c45cef
Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction
Autor:
Johanna Y. Fleischman, Nathan R. Qi, Mary K. Treutelaar, Steven L. Britton, Lauren G. Koch, Jun Z. Li, Charles F. Burant
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101668- (2023)
Objective: Caloric restriction (CR) is one extrinsic intervention that can improve metabolic health, and it shares many phenotypical parallels with intrinsic high cardiorespiratory fitness (CRF), including reduced adiposity, increased cardiometabolic
Externí odkaz:
https://doaj.org/article/6ad0ecfb704e47dfb502e9fa9b84a894
Autor:
Hyunbae Kim, Zhiyao Fu, Zhao Yang, Zhenfeng Song, El Hussain Shamsa, Thangal Yumnamcha, Shengyi Sun, Wanqing Liu, Ahmed S. Ibrahim, Nathan R. Qi, Ren Zhang, Kezhong Zhang
Publikováno v:
Molecular metabolism. 64
The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (MNADK) mediates de novo mitochondrial NADP biosynthesis by catalyzing the phosphorylation of NAD to yield NADP. In this study, we investigated the function and mechanistic basis by whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d23fa1686b5d5e6625820c1349102c
https://pubmed.ncbi.nlm.nih.gov/35944895
https://pubmed.ncbi.nlm.nih.gov/35944895
Autor:
Benjamin P. Tooke, Hui Yu, Jessica M. Adams, Graham L. Jones, Talisha Sutton-Kennedy, Lakshmi Mundada, Nathan R. Qi, Malcolm J. Low, Kavaljit H. Chhabra
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 194-204 (2019)
Objective: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses rema
Externí odkaz:
https://doaj.org/article/f92e3e9e16f84a12bc95b60b5994c889
Autor:
Cai Zhang, Joonbae Seo, Kazutoshi Murakami, Esam S. B. Salem, Elise Bernhard, Vishnupriya J. Borra, Kwangmin Choi, Celvie L. Yuan, Calvin C. Chan, Xiaoting Chen, Taosheng Huang, Matthew T. Weirauch, Senad Divanovic, Nathan R. Qi, Hala Einakat Thomas, Carol A. Mercer, Haruhiko Siomi, Takahisa Nakamura
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disrupt
Externí odkaz:
https://doaj.org/article/38c391e9f41444b882b89e0d90e18efc
Autor:
Lemuel A. Brown, Jennifer L. Judge, Peter C. Macpherson, Lauren G. Koch, Nathan R. Qi, Steven L. Britton, Susan V. Brooks
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
The data described below is related to the manuscript “Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training” [1]. Rodents exhibit age-related declines in skel
Externí odkaz:
https://doaj.org/article/927e20cbcd8b4a529f271e29133ea7c8