Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nathan P. Lavey"'
Autor:
Jimmy D. Ballard, Adam S Duerfeldt, Tyler M. Shadid, Catherine E Bishop, Megan L. Kempher, Nathan P. Lavey
Publikováno v:
J Bacteriol
The Gram-positive bacterium Clostridioides difficile is a primary cause of hospital-acquired diarrhea, threatening both immunocompromised and healthy individuals. An important aspect of defining mechanisms that drive C. difficile persistence and viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d89e26f317c6077b2567f28c48fbb15
https://doi.org/10.1128/jb.00411-21
https://doi.org/10.1128/jb.00411-21
Autor:
Adam S. Duerfeldt, Jimmy D. Ballard, Bishop Ce, Tyler M. Shadid, Nathan P. Lavey, Nagib Ahsan, Megan L. Kempher
The Gram-positive bacterium Clostridioides difficile is a primary cause of hospital-acquired diarrhea, threatening both immunocompromised and healthy individuals. An important aspect of elucidating mechanisms that drive C. difficile persistence and v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32a074964ca2f525095c02fe32f81e2
https://doi.org/10.1101/2021.02.05.429978
https://doi.org/10.1101/2021.02.05.429978
Publikováno v:
ACS Infectious Diseases. 5:79-89
Caseinolytic protease P (ClpP) has emerged as a promising new target for antibacterial development. While ClpPs from single isoform expressing bacteria have been studied in detail, the function and regulation of systems with more than one ClpP homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561594c6205490fba2083d4d1a2371b2
https://doi.org/10.1021/acsinfecdis.8b00199
https://doi.org/10.1021/acsinfecdis.8b00199
Autor:
Jessica E. Knobbe, Yu-Shan Lin, Jesse A. Coker, Yangxiong Li, Adam S. Duerfeldt, Hongtao Yu, Susan L. Nimmo, Dat C. Truong, Nathan P. Lavey
Publikováno v:
ACS medicinal chemistry letters. 8(11)
The acyldepsipeptide (ADEP) antibiotics operate through a clinically unexploited mechanism of action and thus have attracted attention from several antibacterial development groups. The ADEP scaffold is synthetically tractable, and deep-seated modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3263d9060833224ce8ab5ada7626c8a
https://pubmed.ncbi.nlm.nih.gov/29152050
https://pubmed.ncbi.nlm.nih.gov/29152050
Publikováno v:
Journal of natural products. 79(4)
Caseinolytic protease P (ClpP) maintains essential roles in bacterial homeostasis. As such, both the inhibition and activation of this enzyme result in bactericidal activity, making ClpP a promising target for antibacterial drug development. Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479ab646da29206dba71d62c6f103391
https://pubmed.ncbi.nlm.nih.gov/26967980
https://pubmed.ncbi.nlm.nih.gov/26967980