Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Nathan P, Croft"'
Autor:
Asolina Braun, Louise C. Rowntree, Ziyi Huang, Kirti Pandey, Nikolas Thuesen, Chen Li, Jan Petersen, Dene R. Littler, Shabana Raji, Thi H. O. Nguyen, Emma Jappe Lange, Gry Persson, Michael Schantz Klausen, Jens Kringelum, Shanzou Chung, Nathan P. Croft, Pouya Faridi, Rochelle Ayala, Jamie Rossjohn, Patricia T. Illing, Katherine E. Scull, Sri Ramarathinam, Nicole A. Mifsud, Katherine Kedzierska, Anders Bundgård Sørensen, Anthony W. Purcell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Most COVID-19 vaccines elicit immunity against the SARS-CoV-2 Spike protein. However, Spike protein mutations in emerging strains and immune evasion by the SARS-CoV-2 virus demonstrates the need to develop more broadly targeting vaccines. To
Externí odkaz:
https://doaj.org/article/c27b1262e5a94fbaa2a295000016cee8
Autor:
Hayley Goodson, Rebeca Kawahara, Sayantani Chatterjee, Gabriel Goncalves, Joshua Fehring, Anthony W. Purcell, Nathan P. Croft, Morten Thaysen-Andersen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immunopeptidomics, the study of peptide antigens presented on the cell surface by the major histocompatibility complex (MHC), offers insights into how our immune system recognises self/non-self in health and disease. We recently discovered that hyper
Externí odkaz:
https://doaj.org/article/53ee36d9515f4cada11bd942d09ddfa2
Autor:
Prithvi Raj Munday, Joshua Fehring, Jerico Revote, Kirti Pandey, Mohammad Shahbazy, Katherine E. Scull, Sri H. Ramarathinam, Pouya Faridi, Nathan P. Croft, Asolina Braun, Chen Li, Anthony W. Purcell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1678-1687 (2023)
Immunopeptidomics has made tremendous contributions to our understanding of antigen processing and presentation, by identifying and quantifying antigenic peptides presented on the cell surface by Major Histocompatibility Complex (MHC) molecules. Larg
Externí odkaz:
https://doaj.org/article/6efafc027ba14a9c8eafbdadb25b7bb0
Autor:
Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto, Jose M. Polo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a
Externí odkaz:
https://doaj.org/article/9f55b1d1d77043558956af5abec4909b
Autor:
Emma C. Jappe, Christian Garde, Sri H. Ramarathinam, Ethan Passantino, Patricia T. Illing, Nicole A. Mifsud, Thomas Trolle, Jens V. Kringelum, Nathan P. Croft, Anthony W. Purcell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Thermostability of the peptide-MHC interaction is important for immunogenicity. Here the authors present a mass spectrometry method to measure thermostability among thousands of peptide-MHC complexes in parallel and a trained artificial neural networ
Externí odkaz:
https://doaj.org/article/5cf6ee2c88c54b69ae8a7c1723f4491d
Autor:
Ting Wu, Jing Guan, Andreas Handel, David C. Tscharke, John Sidney, Alessandro Sette, Linda M. Wakim, Xavier Y. X. Sng, Paul G. Thomas, Nathan P. Croft, Anthony W. Purcell, Nicole L. La Gruta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and
Externí odkaz:
https://doaj.org/article/4db3dda319094990b8faec74a9a13815
Autor:
Patricia T. Illing, Andy van Hateren, Rachel Darley, Nathan P. Croft, Nicole A. Mifsud, Samuel King, Lyudmila Kostenko, Mandvi Bharadwaj, James McCluskey, Tim Elliott, Anthony W. Purcell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the
Externí odkaz:
https://doaj.org/article/aa6e9a64a82f4a819e31c997dcdb4c3e
Autor:
Gabriel Goncalves, Kerry A. Mullan, Divya Duscharla, Rochelle Ayala, Nathan P. Croft, Pouya Faridi, Anthony W. Purcell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Peptide vaccination remains a viable approach to induce T-cell mediated killing of tumors. To identify potential T-cell targets for Triple-Negative Breast Cancer (TNBC) vaccination, we examined the effect of the pro-inflammatory cytokine interferon-
Externí odkaz:
https://doaj.org/article/bf675c92a1124a84968ed77180b32db9
Autor:
Sinu Paul, Nathan P Croft, Anthony W Purcell, David C Tscharke, Alessandro Sette, Morten Nielsen, Bjoern Peters
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007757 (2020)
T cell epitope candidates are commonly identified using computational prediction tools in order to enable applications such as vaccine design, cancer neoantigen identification, development of diagnostics and removal of unwanted immune responses again
Externí odkaz:
https://doaj.org/article/acf73f978bad4b25803703794d3c428a
Autor:
Patricia T. Illing, Phillip Pymm, Nathan P. Croft, Hugo G. Hilton, Vladimir Jojic, Alex S. Han, Juan L. Mendoza, Nicole A. Mifsud, Nadine L. Dudek, James McCluskey, Peter Parham, Jamie Rossjohn, Julian P. Vivian, Anthony W. Purcell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA
Externí odkaz:
https://doaj.org/article/57210117d3c3489fa9dd810651f36182