Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Nathan N, Alder"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/cd8ce8a04a874c6b91000069736a3f5e
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery and subsequently cleaved to yield the mature protein. MTSs do not have
Externí odkaz:
https://doaj.org/article/e5ebfff110e744498138697bd3793360
Autor:
Wayne Mitchell, Jeffrey D Tamucci, Emery L Ng, Shaoyi Liu, Alexander V Birk, Hazel H Szeto, Eric R May, Andrei T Alexandrescu, Nathan N Alder
Publikováno v:
eLife, Vol 11 (2022)
Mitochondria play a central role in metabolic homeostasis, and dysfunction of this organelle underpins the etiology of many heritable and aging-related diseases. Tetrapeptides with alternating cationic and aromatic residues such as SS-31 (elamipretid
Externí odkaz:
https://doaj.org/article/365e231213024becb3e445b4fd264d5e
Autor:
Elizabeth Calzada, Erica Avery, Pingdewinde N. Sam, Arnab Modak, Chunyan Wang, J. Michael McCaffery, Xianlin Han, Nathan N. Alder, Steven M. Claypool
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Phosphatidylethanolamine (PE) is synthesized by four separate pathways, although surprisingly, perturbing mitochondrial PE synthesis compromises mitochondrial function. Here, the authors show that mitochondrial PE synthesis is required for Complex II
Externí odkaz:
https://doaj.org/article/ca5c4b849f3d4bd9ac4625fe961b2b19
Autor:
Huiliang Zhang, Nathan N Alder, Wang Wang, Hazel Szeto, David J Marcinek, Peter S Rabinovitch
Publikováno v:
eLife, Vol 9 (2020)
Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment is l
Externí odkaz:
https://doaj.org/article/b1614bd25a684cf586da40f56a678a34
Autor:
Nanami Senoo, Dinesh K. Chinthapalli, Matthew G. Baile, Vinaya K. Golla, Bodhisattwa Saha, Oluwaseun B. Ogunbona, James A. Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Dror Chorev, Nathan N. Alder, Eric R. May, Carol V. Robinson, Steven M. Claypool
Publikováno v:
bioRxiv
SummaryThe mitochondrial phospholipid cardiolipin (CL) promotes bioenergetics via oxidative phosphorylation (OXPHOS). Three tightly bound CLs are evolutionarily conserved in the ADP/ATP carrier (AAC in yeast; adenine nucleotide translocator, ANT in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62db7af3c461236f7d1ff1a4f2f4668b
https://europepmc.org/articles/PMC10187269/
https://europepmc.org/articles/PMC10187269/
Autor:
Tingting Zhao, Nathan N. Alder, Angela R. Starkweather, Ming-Hui Chen, Adam P. Matson, Wanli Xu, Jeremy L. Balsbaugh, Xiaomei Cong
Publikováno v:
Developmental Neuroscience. 44:438-454
Early life stress is commonly experienced by infants, especially preterm infants, and may impact their neurodevelopmental outcomes in their early and later lives. Mitochondrial function/dysfunction may play an important role underlying the linkage of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945b9ce5a2bc957eddf27d6ec4b6670a
https://doi.org/10.1159/000526491
https://doi.org/10.1159/000526491
Publikováno v:
Biophysical Journal. 122:93a-94a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::204689f02d4e75a84916c0dc991d8376
https://doi.org/10.1016/j.bpj.2022.11.702
https://doi.org/10.1016/j.bpj.2022.11.702
Autor:
Wayne Mitchell, Nicholas A. Eddy, Xianlin Han, Jeffrey D. Tamucci, Murugappan Sathappa, Eric R. May, Kevin J. Boyd, Nathan N. Alder, Hazel H. Szeto, Adrian Coscia, Emily A. Ng, Meixia Pan
Publikováno v:
The Journal of Biological Chemistry
Mitochondrial dysfunction underlies many heritable diseases, acquired pathologies, and aging-related declines in health. Szeto–Schiller (SS) peptides comprise a class of amphipathic tetrapeptides that are efficacious toward a wide array of mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a25e47da785e61e57245ccc7da8257
https://doi.org/10.1074/jbc.ra119.012094
https://doi.org/10.1074/jbc.ra119.012094