Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Nathan Lawlor"'
Autor:
Wonhyoung Seo, Seungyeul Yoo, Yi Zhong, Sang-Hee Lee, Soo-Yeon Woo, Hee-Seon Choi, Minho Won, Taylor Roh, Sang Min Jeon, Kyeong Tae Kim, Prashanta Silwal, Min Joung Lee, Jun Young Heo, Nathan Lawlor, Sup Kim, Dongjun Lee, Jin-Man Kim, Ik-Chan Song, Jun Zhu, Eun-Kyeong Jo
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Acute myeloid leukemia (AML) is an aggressive blood cancer with poor clinical outcomes. Emerging data suggest that mitochondrial oxidative phosphorylation (mtOXPHOS) plays a significant role in AML tumorigenesis, progression, and resistance
Externí odkaz:
https://doaj.org/article/8edec9bceb4d4baeaecc2bb89886e73e
Autor:
Asa Thibodeau, Alper Eroglu, Christopher S. McGinnis, Nathan Lawlor, Djamel Nehar-Belaid, Romy Kursawe, Radu Marches, Daniel N. Conrad, George A. Kuchel, Zev J. Gartner, Jacques Banchereau, Michael L. Stitzel, A. Ercument Cicek, Duygu Ucar
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging due to data sparsity and limited dynamic range. AMULET (ATAC-seq MULtiplet Estimation Tool) enumerates regions with greater than two uniquely aligned reads across the ge
Externí odkaz:
https://doaj.org/article/16ab6a3786b04036bf43b168af964002
Autor:
Jinxiu Rui, Songyan Deng, Ana Luisa Perdigoto, Gerald Ponath, Romy Kursawe, Nathan Lawlor, Tomokazu Sumida, Maya Levine-Ritterman, Michael L. Stitzel, David Pitt, Jun Lu, Kevan C. Herold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2
Externí odkaz:
https://doaj.org/article/d2099481cf7c45539fc5dd7688d09511
Autor:
Nathan Lawlor, Djamel Nehar-Belaid, Jessica D.S. Grassmann, Marlon Stoeckius, Peter Smibert, Michael L. Stitzel, Virginia Pascual, Jacques Banchereau, Adam Williams, Duygu Ucar
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immune cell activation assays have been widely used for immune monitoring and for understanding disease mechanisms. However, these assays are typically limited in scope. A holistic study of circulating immune cell responses to different activators is
Externí odkaz:
https://doaj.org/article/c7dfcc8421ac4e46a4a5b92efb8db88e
Autor:
Nathan Lawlor, Michael L. Stitzel
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp S15-S24 (2019)
Background: Pancreatic Islets of Langerhans are heterogeneous tissues consisting of multiple endocrine cell types that carry out distinct yet coordinated roles to regulate blood glucose homeostasis. Islet dysfunction and specifically failure of the b
Externí odkaz:
https://doaj.org/article/7182bfcd1d5a41c19dc126dcb6bd0ee4
Publikováno v:
Cancer Informatics, Vol 2016, Iss 15, Pp 103-114 (2016)
Externí odkaz:
https://doaj.org/article/6b371ac6ce4647a7b9a30da07411d8ad
Autor:
Gemma L. Pearson, Emily M. Walker, Nathan Lawlor, Anne Lietzke, Vaibhav Sidarala, Jie Zhu, Tracy Stromer, Emma C. Reck, Jin Li, Aaron Renberg, Kawthar Mohamed, Vishal S. Parekh, Irina X. Zhang, Benjamin Thompson, Deqiang Zhang, Sarah A. Ware, Leena Haataja, Stephen C.J. Parker, Peter Arvan, Lei Yin, Brett A. Kaufman, Leslie S. Satin, Lori Sussel, Michael L. Stitzel, Scott A. Soleimanpour
Mitochondrial dysfunction is a hallmark of metabolic diseases, including diabetes, yet the consequences of mitochondrial damage in metabolic tissues are often unclear. Here, we report that mitochondrial dysfunction engages a retrograde (mitonuclear)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e517b42d9cbfc566e59056e5b624ac9
https://doi.org/10.1101/2022.08.02.502357
https://doi.org/10.1101/2022.08.02.502357
Autor:
Nathan Lawlor, Daniel N. Conrad, Djamel Nehar-Belaid, Michael L. Stitzel, Asa Thibodeau, Radu Marches, Zev J. Gartner, A. Ercument Cicek, George A. Kuchel, Romy Kursawe, Alper Eroglu, Jacques Banchereau, Duygu Ucar, Christopher S. McGinnis
Publikováno v:
Genome Biology
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging due to data sparsity and limited dynamic range. AMULET (ATAC-seq MULtiplet Estimation Tool) enumerates regions with greater than two uniquely aligned reads across the genome to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c958fd23a0ee143ff9733456be355c5a
https://hdl.handle.net/11693/77279
https://hdl.handle.net/11693/77279
Autor:
Jie Zhu, Nathan Lawlor, Gemma L. Pearson, Emily M. Walker, Michael L. Stitzel, Scott A. Soleimanpour, Emma C. Reck
Publikováno v:
Diabetes. 70
Mitochondrial function is pivotal to β-cell competence. The mitochondrial life cycle balances mitochondrial biogenesis and turnover (mitophagy) to ensure optimal metabolic function. Human type 2 diabetic (T2D) β-cells are known to develop mitochond
Publikováno v:
Bioinformatics
Summary Single-cell RNA-sequencing (scRNA-seq) technology enables studying gene expression programs from individual cells. However, these data are subject to diverse sources of variation, including ‘unwanted’ variation that needs to be removed in