Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nathan L. Shipkowitz"'
Autor:
Nathan L. Shipkowitz, B Flamm, J. Meulbroek, M. Mitten, K. Jarvis, T Hutch, A. Oleksijew, L. Paige, Jacob J. Clement, Jeffrey Alder
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:971-975
The 2-pyridones are a new class of broad-spectrum orally bioavailable antibacterial agents. These compounds are potent bacterial DNA gyrase inhibitors which differ from fluoroquinolones by placement of the nitrogen atom in the ring juncture. ABT-719
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a72b0d91807d2fd9b3a8959d3643523
https://doi.org/10.1128/aac.39.4.971
https://doi.org/10.1128/aac.39.4.971
Autor:
N C Ramer, C. W. Hanson, R N Swanson, P B Fernandes, Dwight J. Hardy, J J Clement, Nathan L. Shipkowitz
Publikováno v:
Antimicrobial Agents and Chemotherapy. 35:1108-1111
Tiacumicins B and C are members of a novel group of 18-membered macrolide antibiotics with in vitro activity against Clostridium difficile. The MICs against 15 strains of C. difficile were 0.12 to 0.25 microgram/ml for tiacumicin B, 0.25 to 1 microgr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8025e9bcba00af2ed199d1bd2163314d
https://doi.org/10.1128/aac.35.6.1108
https://doi.org/10.1128/aac.35.6.1108
Publikováno v:
Antimicrobial Agents and Chemotherapy. 35:423-429
The activity of the quinolone temafloxacin against respiratory pathogens was compared with those of ciprofloxacin and ofloxacin. MICs for 90% of strains tested indicated that temafloxacin was at least two- to fourfold more potent than the other two q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593f772a940dfa279872c1ecfee34f2e
https://doi.org/10.1128/aac.35.3.423
https://doi.org/10.1128/aac.35.3.423
Autor:
L A Freiberg, Nathan L. Shipkowitz, Dwight J. Hardy, R N Swanson, Paul A. Lartey, J J Clement
Publikováno v:
Antimicrobial agents and chemotherapy. 35(5)
Analogs of 9-deoxo-12-deoxy-9,12-epoxyerythromycin A with an epimeric hydroxy, amino, or ketone substitution at the 11 position of the macrolide ring and an amino or epimeric hydroxy substitution at the 4" position of the cladinose sugar were synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027fd067923b73603aa2bb162abf1672
https://pubmed.ncbi.nlm.nih.gov/1854173
https://pubmed.ncbi.nlm.nih.gov/1854173
Autor:
Hiroaki Mitsuya, Samuel Broder, Earl R. Kern, W. Shannon, William Rosenbrook, Kennan C. Marsh, Robert N. Swanson, D. J. Hardy, G. Arnett, Thomas Herrin, Jacob J. Clement, D. W. Norbeck, Nathan L. Shipkowitz, S. Hayashi, J. J. Plattner, H. L. Sham, John W. Erickson
Publikováno v:
ChemInform. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c08d9eba819d9ce7c201447b4f287acd
https://doi.org/10.1002/chin.199048292
https://doi.org/10.1002/chin.199048292
Publikováno v:
Antimicrobial agents and chemotherapy. 34(7)
MICs of clarithromycin and its major human metabolite, 14-hydroxy-clarithromycin, for Haemophilus influenzae in combination were reduced two- to fourfold compared with the MICs of each compound alone. Serum reduced the MICs of the parent compound and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf08e9929f240244892700e683a5d67
https://pubmed.ncbi.nlm.nih.gov/2143642
https://pubmed.ncbi.nlm.nih.gov/2143642
Autor:
K. P. Jarvis, N. R. Ramer, Robert R. Bower, P B Fernandes, D. T. W. Chu, Nathan L. Shipkowitz
Publikováno v:
Antimicrobial Agents and Chemotherapy. 29:201-208
A-56619 and A-56620 are two new aryl-fluoroquinolones which are as potent as or more potent than norfloxacin when administered orally and subcutaneously in mouse protection tests against Staphylococcus aureus, Streptococcus pyogenes, and Streptococcu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d33efb599d9487a195560add2869b5
https://doi.org/10.1128/aac.29.2.201
https://doi.org/10.1128/aac.29.2.201
Autor:
John M. Stamm, Nathan L. Shipkowitz, Charlene M. Vojtko, Prabhavathi B. Fernandes, Edward St. Martin, Charles W. Hanson
Publikováno v:
Journal of Antimicrobial Chemotherapy. 19:449-465
The frequency of development of resistance to the fluoroquinolones in vitro was generally low with Escherichia coli (in the order of 10(-7) to less than 10(-9) and high with Pseudomonas aeruginosa (in the order of 10(-5) to 10(-7)). Susceptibility to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82de4313290137eb62764ec4a0f6cc8e
https://doi.org/10.1093/jac/19.4.449
https://doi.org/10.1093/jac/19.4.449
Autor:
Robert R. Bower, Daniel T. W. Chu, Kenneth P. Jarvis, Prabhavathi B. Fernandes, Jonina Weisz, Nathan L. Shipkowitz
Publikováno v:
Journal of Antimicrobial Chemotherapy. 18:693-701
The MICs of difloxacin (A-56619), A-56620 and ofloxacin were similar or within one to two-fold dilutions against a variety of anaerobic bacteria. Ciprofloxacin was slightly less active (two- to four-fold dilutions) than difloxacin, A-56620 and ofloxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691a5c718d911f1bbc0cdd9ca1437d37
https://doi.org/10.1093/jac/18.6.693
https://doi.org/10.1093/jac/18.6.693
Publikováno v:
Antimicrobial agents and chemotherapy. 19(3)
The in vitro activity of cefmenoxime (SCE-1365 or A-50912), a new semisynthetic cephalosporin antibiotic, was compared with those of cefazolin, cefoxitin, and cefamandole against a broad spectrum of 486 organisms and with that of cefotaxime against 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1a008d21b8bb4d0d3ed6a8f0b11ed8
https://pubmed.ncbi.nlm.nih.gov/6264846
https://pubmed.ncbi.nlm.nih.gov/6264846