Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Nathan K. Lebrasseur"'
Autor:
Jielu Hao Robichaud, Yingyi Zhang, Chuan Chen, Kai He, Yan Huang, Xu Zhang, Xiaobo Sun, Xiaoyu Ma, Gary Hardyman, Ciaran G. Morrison, Zheng Dong, Nathan K. LeBrasseur, Kun Ling, Jinghua Hu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Despite the importance of cellular senescence in human health, how damaged cells undergo senescence remains elusive. We have previously shown that promyelocytic leukemia nuclear body (PML-NBs) translocation of the ciliary FBF1 is essential f
Externí odkaz:
https://doaj.org/article/775317152ced4b5da1b5be5d1a47e362
Autor:
Lu Yang, Yan Er Ng, Haipeng Sun, Ying Li, Lucas C. S. Chini, Nathan K. LeBrasseur, Jun Chen, Xu Zhang
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Single-cell RNA-sequencing (scRNA-seq) has become a widely used tool for both basic and translational biomedical research. In scRNA-seq data analysis, cell type annotation is an essential but challenging step. In the past few year
Externí odkaz:
https://doaj.org/article/0f87fa342e7a41b09999a4b868c35f48
Autor:
Xiaoyu Ma, Yingyi Zhang, Yuanyuan Zhang, Xu Zhang, Yan Huang, Kai He, Chuan Chen, Jielu Hao, Debiao Zhao, Nathan K. LeBrasseur, James L. Kirkland, Eduardo N. Chini, Qing Wei, Kun Ling, Jinghua Hu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells. Fbf1 ablation reduces senescence and associated health decline in mice, highlighting cil
Externí odkaz:
https://doaj.org/article/880ce8033dc74d578533b640039e7438
Autor:
Zaira Aversa, Elizabeth J. Atkinson, Eva M. Carmona, Thomas A. White, Amanda A. Heeren, Sarah K. Jachim, Xu Zhang, Steven R. Cummings, Sergio E. Chiarella, Andrew H. Limper, Nathan K. LeBrasseur
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Cellular senescence is a cell fate in response to diverse forms of age-related damage and stress that has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The associations between circulating levels of c
Externí odkaz:
https://doaj.org/article/8d4a4dd058af433191e03b3e30beda89
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
Externí odkaz:
https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Autor:
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, João F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
Externí odkaz:
https://doaj.org/article/e07e402c5be742719a9abae3ab241ab2
Autor:
Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) th
Externí odkaz:
https://doaj.org/article/fc80a778d0594c49a7d28805675dc1fe
Autor:
Sandra Zampieri, Ines Bersch, Helmut Kern, Nejc Sarabon, Riccardo Rosati, Nathan K. LeBrasseur, Christiaan Leeuwenburg, Ugo Carraro
Publikováno v:
European Journal of Translational Myology (2023)
The 2023 Padua Days of Muscle and Mobility Medicine (Pdm3) were held from March 29th to April 1st, 2023. Most of the abstracts were published electronically in the European Journal of Translational Myology (EJTM) 33 (1) 2023. Here we report the compl
Externí odkaz:
https://doaj.org/article/cb45ca36b80e42d2a2691350e68c98c1
Autor:
Davis A. Englund, Alyssa Jolliffe, Zaira Aversa, Xu Zhang, Ines Sturmlechner, Ayumi E. Sakamoto, Julianna D. Zeidler, Gina M. Warner, Colton McNinch, Thomas A. White, Eduardo N. Chini, Darren J. Baker, Jan M. van Deursen, Nathan K. LeBrasseur
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101652- (2023)
Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse model of p21 overexpression (p21OE), we examined if p21 mechanistically contributes
Externí odkaz:
https://doaj.org/article/d4615090d69c464288f4371a6d95f0e6
Autor:
LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, Yi Zhu, Tamara Tchkonia, James L. Kirkland
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 446-456 (2019)
Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including
Externí odkaz:
https://doaj.org/article/0d43e885c44b49ce9dfa80c8a91636b9