Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nathan J. Sacks"'
Autor:
Alex M. Jaeger, JJ Patten, Olivia Smith, Haley Hauck, Ömer H. Yilmaz, Tyler Jacks, George Eng, Peter M. K. Westcott, Jason M. Schenkel, Coralie Backlund, Ryan Elbashir, Darrell J. Irvine, Zackery A. Ely, Daniel Zhang, Nathan J. Sacks, Mary Clare Beytagh
Publikováno v:
Nature Cancer. 2:1071-1085
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (for example, those with microsatellite instability). Whether low TMB cancers, which a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4273c6894f082d2418205f8f333ecec5
https://doi.org/10.1038/s43018-021-00247-z
https://doi.org/10.1038/s43018-021-00247-z
Autor:
Alex M. Jaeger, David Canner, Mary Clare Beytagh, JJ Patten, William M. Rideout, Haley Hauck, Isidro Cortes-Ciriano, Santiago Naranjo, Abbey Jin, Zackery A. Ely, Tyler Jacks, Nathan J. Sacks, Roderick T. Bronson, Peter M. K. Westcott, Francesc Muyas, Arjun Bhutkar, Olivia Smith, Daniel Zhang, Amanda M. Cruz
DNA mismatch repair deficiency (MMRd) is associated with high tumor mutational burden (TMB), increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) therapy1. Nevertheless, about half of MMRd tumors do not res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f615eadc4d03bce6cde32dfce858f582
https://doi.org/10.21203/rs.3.rs-879464/v1
https://doi.org/10.21203/rs.3.rs-879464/v1
Autor:
Alex M. Jaeger, Zackery A. Ely, Peter M. K. Westcott, Amanda M. Cruz, David Canner, Francesc Muyas, Mary Clare Beytagh, JJ Patten, Isidro Cortes-Ciriano, Haley Hauck, Abbey Jin, Roderick T. Bronson, Santiago Naranjo, Daniel Zhang, William M. Rideout, Tyler Jacks, Arjun Bhutkar, Nathan J. Sacks, Olivia Smith
DNA mismatch repair deficiency (MMRd) in human cancer is associated with high tumor mutational burden (TMB), frameshift mutation-derived neoantigens, increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa7b8c8cec8f49449a9abd0ac0e96334
https://doi.org/10.1101/2021.08.24.457572
https://doi.org/10.1101/2021.08.24.457572
Autor:
Peter M. K. Westcott, Francesc M. Remolar, Olivia Smith, Haley Hauck, Nathan J. Sacks, Zackery A. Ely, Alex M. Jaeger, William M. Rideout, Arjun Bhutkar, Daniel Zhang, Mary C. Beytagh, Roderick T. Bronson, David A. Canner, Santiago Naranjo, Abbey Jin, J. J. Patten, Amanda M. Cruz, Isidro Cortes-Ciriano, Tyler Jacks
Publikováno v:
Cancer Immunology Research. 10:P023-P023
Deficient DNA mismatch repair (dMMR) in human cancer is associated with high tumor mutation burden (TMB), frameshift mutation-derived neoantigens, increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1272669bb0c279e48d8196dce221628
https://doi.org/10.1158/2326-6074.tumimm21-p023
https://doi.org/10.1158/2326-6074.tumimm21-p023
Autor:
Mary Clare Beytagh, William L. Hwang, Olivia Smith, Peter M. K. Westcott, Omer H Yilmaz, Tyler Jacks, Nathan J. Sacks, Jatin Roper, Jason M. Schenkel, Zackery A. Ely, George Eng, Daniel Zhang
Publikováno v:
Cancer Research. 80:3447-3447
Genetically-engineered mouse models have greatly advanced our understanding of cancer, yet do not recapitulate the mutational complexity of human cancer, and likely lack neo-antigens capable of eliciting potent anti-tumor T cell responses. We develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da4b6150a4cc619711bb163bc7de8c51
https://doi.org/10.1158/1538-7445.am2020-3447
https://doi.org/10.1158/1538-7445.am2020-3447
Autor:
Tuomas Pitkänen, Sami Blom, Katherine Wu, Tyler Jacks, Tuomas Tammela, Peter M. K. Westcott, Tuomas Ropponen, Roderick T. Bronson, Thomas Westerling, Nathan J. Sacks
Publikováno v:
Cancer Research. 79:4447-4447
Lung cancer is the leading cause of cancer-related deaths worldwide, and genetically-engineered mouse models (GEMMs) of cancer provide important mechanistic and preclinical insights into this deadly disease. In particular, the “KP” model enables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d67b99ba3ef512faef24388a92506af
https://doi.org/10.1158/1538-7445.am2019-4447
https://doi.org/10.1158/1538-7445.am2019-4447