A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson’s Disease in Participants With Leucine‐Rich Repeat Kinase 2 Mutation

Autor: Caroline H. Williams-Gray, Diane Stephenson, Klaus Romero, Judith Anton, Ferdous Gheyas, Nathan J. Hanan, Jonas Weidemann, Minhua Yang, Malidi Ahamadi, Massimo Bani, Bob Stafford, Charles S. Venuto, Chao Chen, Vincent Thuillier, Ka Lai Yee, Gennaro Pagano, Monica Javidnia, Sreeraj Macha, Nitin Mehrotra, Vikram Sinha, Kenneth Marek, Yaming Hang, Hans Smit, Anne Pedata, Mussie Akalu, Babak Boroojerdi, David T. Dexter, Glenn T. Stebbins

Publikováno v: Clinical Pharmacology & Therapeutics. 110:508-518

Leucine-rich repeat kinase 2 (LRRK2) inhibitors are currently in clinical development as interventions to slow progression of Parkinson's disease (PD). Understanding the rate of progression in PD as measured by both motor and non-motor features is pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9053473f0a3b3a25461e5d893d23049
https://doi.org/10.1002/cpt.2277

Graphical user interfaces for regulatory‐endorsed quantitative drug development tools in Alzheimer’s disease

Autor: Samantha Budd Haeberlein, Klaus Romero, Michael Gold, Sudhir Sivakumaran, Nathan J. Hanan, Vikram Sinha

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8caa733602b0de341410c1ae2fa1dd1a
https://doi.org/10.1002/alz.044029

Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk

Autor: Kerri Bertrand, Brookie M. Best, Gordon Honerkamp-Smith, Christina D. Chambers, Nathan J. Hanan

Publikováno v: Pediatrics, vol 142, iss 3
Bertrand, KA; Hanan, NJ; Honerkamp-Smith, G; Best, BM; & Chambers, CD. (2018). Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk. PEDIATRICS, 142(3). doi: 10.1542/peds.2018-1076. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0jq9p4f2

BACKGROUND AND OBJECTIVE: Marijuana is the most commonly used recreational drug among breastfeeding women. With legalization of marijuana in several US states and a 1990 study in which authors documented psychomotor deficits in infants breastfed by m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1f8be3254983c28405b6020a7d8e66
https://escholarship.org/uc/item/0jq9p4f2

Modeling Nikkomycin Z Dosing and Pharmacology in Murine Pulmonary Coccidioidomycosis Preparatory to Phase 2 Clinical Trials

Autor: Hien T. Trinh, Lisa F. Shubitz, David E. Nix, Nathan J. Hanan, John N. Galgiani, Robert Perrill, C. Michael Thompson

Nikkomycin Z (NikZ) is a chitin synthase inhibitor with activity against Coccidioides species that is being developed as a first-in-class orphan product for treatment of coccidioidomycosis. It has previously been shown to reduce lethal respiratory in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1730af6747b02f7425461dc99d6ae899
https://europepmc.org/articles/PMC4038145/