Výsledky vyhledávání - "Nathan J. D. McLaughlin"

Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation

Autor: David J. Elzi, Samina Y. Khan, Anirban Banerjee, Kelly M. England, Susan Kuldanek, Christopher C. Silliman, F. Bernadette West, Jason Bjornsen, Nathan J. D. McLaughlin, Marguerite R. Kelher

Publikováno v: Transfusion. 57:2690-2700

BACKGROUND Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored red blood cells (RBCs) induce proinflammatory activation of human pulmonary microvascular en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7274dfa6a8900ffb7d9a4b99defb21b
https://doi.org/10.1111/trf.14271

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Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation

Autor: Christopher C, Silliman, Marguerite R, Kelher, Samina Y, Khan, F Bernadette, West, Nathan J D, McLaughlin, David J, Elzi, Kelly, England, Jason, Bjornsen, Susan A, Kuldanek, Anirban, Banerjee

Publikováno v: Transfusion. 57(11)

Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored red blood cells (RBCs) induce proinflammatory activation of human pulmonary microvascular endothelial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b145dfd669a0026254232da05c79539
https://pubmed.ncbi.nlm.nih.gov/28880373

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LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils

Autor: Christopher C. Silliman, Xianzhong Meng, Nathan J. D. McLaughlin, Marguerite R. Kelher, Anirban Banerjee, Sanchayita Mitra, Fabia Gamboni, Samina Y. Khan, David J. Elzi

Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury (TRALI). LysoPCs cause ligation of the G2A receptor, cytosolic Ca2+ flux, and activation of Hck. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726f8e1e665ae4479f2808bb779d2c42
https://europepmc.org/articles/PMC5166440/

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Leukotriene B4 and its Metabolites Prime the Neutrophil Oxidase and Induce Proinflammatory Activation of Human Pulmonary Microvascular Endothelial Cells

Autor: John C. Eun, Anirban Banerjee, Marguerite R. Kelher, David J. Elzi, Nathan J. D. McLaughlin, Christopher C. Silliman, Ernest E. Moore, Samina Y. Khan

Publikováno v: Shock. 35:240-244

Leukotrienes are proinflammatory lipid mediators, derived from arachidonic acid via 5-lipoxygenase (5-LO). Leukotriene B4 (LTB4) is an effective polymorphonuclear neutrophil (PMN) chemoattractant, as well as being a major product of PMN priming. Leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1f269850251136a2da264aef0d1b75
https://doi.org/10.1097/shk.0b013e3181faceb3

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Lysophosphatidylcholines activate G2A inducing Gαi-1-/Gαq/11- Ca2+ flux, Gβγ-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Autor: Samina Y. Khan, Anirban Banerjee, Marguerite R. Kelher, Phillip Eckels, Christopher C. Silliman, Fabia Gamboni-Robertson, Nathan J. D. McLaughlin

Publikováno v: Biochemical Journal. 432:35-45

Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TRALI (transfusion-related acute lung injury) and directly affect the physiology of neutrophils [PMNs (po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1e0f983986b818a12aa1f8cccea9596
https://doi.org/10.1042/bj20091087

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Platelet-Activating Factor-Induced Clathrin-Mediated Endocytosis Requires β-Arrestin-1 Recruitment and Activation of the p38 MAPK Signalosome at the Plasma Membrane for Actin Bundle Formation

Autor: Ernest E. Moore, Marguerite R. Kelher, Nathan J. D. McLaughlin, Anirban Banerjee, Fabia Gamboni-Robertson, Forest R. Sheppard, Christine Hamiel, Christopher C. Silliman

Publikováno v: The Journal of Immunology. 176:7039-7050

Clathrin-mediated endocytosis (CME) is a common pathway used by G protein-linked receptors to transduce extracellular signals. We hypothesize that platelet-activating factor (PAF) receptor (PAFR) ligation requires CME and causes engagement of β-arre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34751a5cdaab565e89897aebe504c5a
https://doi.org/10.4049/jimmunol.176.11.7039

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Clinically Relevant Osmolar Stress Inhibits Priming-Induced PMN NADPH Oxidase Subunit Translocation

Autor: Forest R. Sheppard, Ernest E. Moore, Margarite Kelher, Jeffrey L. Johnson, Christopher C. Silliman, Nathan J. D. McLaughlin

Publikováno v: The Journal of Trauma: Injury, Infection, and Critical Care. 58:752-757

Background: The plasma membrane NADPH oxidase is responsible for the external generation of superoxide by neutrophils (polymorphonucleocytes [PMNs]). The oxidase is a multicomponent enzyme, active only when all subunits are translocated to and assemb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0284b5f98ed4143f8fc897199d7d4a
https://doi.org/10.1097/01.ta.0000159246.33364.72

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Hyperosmolarity attenuates TNF-α-mediated proinflammatory activation of human pulmonary microvascular endothelial cells

Autor: Ernest E. Moore, Anirban Banerjee, Wilbert L. Jones, Luis Lee, Jeffrey L. Johnson, Nathan J. D. McLaughlin, Trevor L. Nydam, Christopher C. Silliman

Publikováno v: Shock (Augusta, Ga.). 39(4)

Firm neutrophil (PMN)-endothelial (EC) adhesion is crucial to the PMN-mediated hyperinflammation observed in acute lung injury. Hypertonic saline (HTS) used for resuscitation of hemorrhagic shock has been associated with a decreased incidence of PMN-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e6ece155d59f4904e67bda21badafa
https://pubmed.ncbi.nlm.nih.gov/23364439

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A two-event in vitro model of acute chest syndrome: the role of secretory phospholipase A2 and neutrophils

Autor: J Bradley, Ball, Samina Y, Khan, Nathan J D, McLaughlin, Marguerite R, Kelher, Rachelle, Nuss, Laura, Cole, Xiayuan, Liang, Christopher C, Silliman

Publikováno v: Pediatric bloodcancer. 58(3)

Acute chest syndrome (ACS) in sickle cell disease is associated with elevation of secretory phospholipase A(2) (sPLA(2) ). We hypothesize that sPLA(2) cleaves membrane lipids from sickled red blood cells (RBCs) causing PMN-mediated endothelial cell i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22e3c6a007c5efb1ad8b24987edce8df
https://pubmed.ncbi.nlm.nih.gov/21793188

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Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Autor: Samina Y, Khan, Nathan J D, McLaughlin, Marguerite R, Kelher, Phillip, Eckels, Fabia, Gamboni-Robertson, Anirban, Banerjee, Christopher C, Silliman

Publikováno v: The Biochemical journal. 432(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5742ce181c430bc4d5b5de3cdc3c9a84
https://pubmed.ncbi.nlm.nih.gov/20799926

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