Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Nathan J. Brendish"'
Autor:
Rebekah Penrice-Randal, Xiaofeng Dong, Andrew George Shapanis, Aaron Gardner, Nicholas Harding, Jelmer Legebeke, Jenny Lord, Andres F. Vallejo, Stephen Poole, Nathan J. Brendish, Catherine Hartley, Anthony P. Williams, Gabrielle Wheway, Marta E. Polak, Fabio Strazzeri, James P. R. Schofield, Paul J. Skipp, Julian A. Hiscox, Tristan W. Clark, Diana Baralle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe COVID-19 pandemic has created pressure on healthcare systems worldwide. Tools that can stratify individuals according to prognosis could allow for more efficient allocation of healthcare resources and thus improved patient outcomes. It
Externí odkaz:
https://doaj.org/article/919dbb10fdda47859e6b536e0d1cbd3a
Autor:
Jelmer Legebeke, Jenny Lord, Rebekah Penrice-Randal, Andres F. Vallejo, Stephen Poole, Nathan J. Brendish, Xiaofeng Dong, Catherine Hartley, John W. Holloway, Jane S. Lucas, Anthony P. Williams, Gabrielle Wheway, Fabio Strazzeri, Aaron Gardner, James P. R. Schofield, Paul J. Skipp, Julian A. Hiscox, Marta E. Polak, Tristan W. Clark, Diana Baralle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The worldwide COVID-19 pandemic has claimed millions of lives and has had a profound effect on global life. Understanding the body’s immune response to SARS-CoV-2 infection is crucial in improving patient management and prognosis. In this study we
Externí odkaz:
https://doaj.org/article/f46b555a1c314f3fb50bd6cabe819aa8
Publikováno v:
Clinical Infection in Practice, Vol 11, Iss , Pp 100075- (2021)
Background: UK Public Health England (PHE) guidelines recommend the liberal use of neuraminidase inhibitors (NAIs) in hospitalised adults with suspected influenza and are aligned with international guidelines. NAI use is recommended to start as early
Externí odkaz:
https://doaj.org/article/351a0bfce9324e2f810659348b5fd080
Autor:
Hans de Graaf, Ruth O. Payne, Iona Taylor, Kazutoyo Miura, Carol A. Long, Sean C. Elias, Marija Zaric, Angela M. Minassian, Sarah E. Silk, Lee Li, Ian D. Poulton, Megan Baker, Simon J. Draper, Diane Gbesemete, Nathan J. Brendish, Filipa Martins, Arianna Marini, David Mekhaiel, Nick J. Edwards, Rachel Roberts, Johan Vekemans, Sarah Moyle, Saul N. Faust, Eleanor Berrie, Alison M. Lawrie, Fergal Hill, Adrian V. S. Hill, Sumi Biswas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundTransmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria. The Plasmodium falciparum Pfs25 protein (Pfs25) is the most clinically advanced ca
Externí odkaz:
https://doaj.org/article/daf9bdd8e4a1400a9c2b0c0584c0a152
Publikováno v:
European Respiratory Review, Vol 30, Iss 159 (2021)
Influenza virus infection causes seasonal epidemics and occasional pandemics, leading to huge morbidity and mortality worldwide. Vaccination against influenza is needed annually as protection from constantly mutating strains is required. Groups at hi
Externí odkaz:
https://doaj.org/article/38cd6c37759c496c9945311569c30f0c
Autor:
Nathan J. Brendish, Alex R. Tanner, Stephen Poole, Kate R. Beard, Vasanth V. Naidu, Christopher T. Mansbridge, Nicholas J. Norton, Helen Wheeler, Laura Presland, Tristan W. Clark
Publikováno v:
Infectious Diseases and Therapy. 11:1267-1280
Introduction: RT-PCR has suboptimal sensitivity for the diagnosis of COVID-19. A composite reference standard comprising RT-PCR plus radiological and clinical features has been recommended for diagnostic accuracy studies. The FebriDx finger prick poi
Publikováno v:
The Journal of Infection
SARS-CoV-2 viral load at presentation to hospital is independently associated with the risk of death
Autor:
Kate R Beard, Hang Phan, Florina Borca, Tristan W Clark, Nathan J Brendish, Alex R Tanner, Stephen Poole
Publikováno v:
The Journal of Infection
Objectives: Previous studies have suggested that SARS-CoV-2 viral load, measured on upper respiratory tract samples at presentation to hospital using PCR Cycle threshold (Ct) value, has prognostic utility. However, these studies have not comprehensiv
Autor:
Stephen Poole, Mark Jones, Ben Welham, Lee Dexter, Tristan W Clark, Christopher McQuitty, Jose Horno, Emily Heiden, Tim Jm Wallis, Anna Freeman, Mark Watson, Tom Wilkinson, Hannah Burke, Ben G. Marshall, Alex Kong, Nathan J Brendish, Aishath Fazleen
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-9 (2021)
Respiratory Research
Respiratory Research
Background The long-term consequences of COVID-19 remain unclear. There is concern a proportion of patients will progress to develop pulmonary fibrosis. We aimed to assess the temporal change in CXR infiltrates in a cohort of patients following hospi
Autor:
Ahalya K. Malachira, Tristan W Clark, Stephen Poole, Nick Cortes, Laura Presland, Samuel Mills, Kate R Beard, Cathleen Chan, Esther Nyimbili, Sean Ewings, Nathan J Brendish
Publikováno v:
The Lancet Respiratory Medicine. 9:419-429
Summary Background Diagnosis of influenza in patients admitted to hospital is delayed due to long turnaround times with laboratory testing, leading to inappropriate and late antiviral treatment and isolation facility use. Molecular point-of-care test