Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nathan J Schuld"'
Autor:
Nathan J Schuld, Stacy A Hussong, Rebecca J Kapphahn, Ute Lehmann, Heidi Roehrich, Abrar A Rageh, Neal D Heuss, Wendy Bratten, Dale S Gregerson, Deborah A Ferrington
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126768 (2015)
The immunoproteasome is upregulated by disease, oxidative stress, and inflammatory cytokines, suggesting an expanded role for the immunoproteasome in stress signaling that goes beyond its canonical role in generating peptides for antigen presentation
Externí odkaz:
https://doaj.org/article/9b2560ec4c69478f833ffd1608d41a17
Autor:
Carol L. Williams, Alexander C. Mackinnon, Jian Huang, Ellen L. Lorimer, Xiuxu Chen, Nathan J. Schuld, Carmen Bergom, Andrew D. Hauser
PDF - 139KB, Supplementary Materials and Methods; Supplementary Figure S1: MDA-MB-231 cells have more detergent soluble prenylated RhoA than RhoC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95e3dbd053c5b50965708505f9a43c3
https://doi.org/10.1158/1541-7786.22509246.v1
https://doi.org/10.1158/1541-7786.22509246.v1
Autor:
Carol L. Williams, Alexander C. Mackinnon, Jian Huang, Ellen L. Lorimer, Xiuxu Chen, Nathan J. Schuld, Carmen Bergom, Andrew D. Hauser
Breast cancer malignancy is promoted by the small GTPases RhoA and RhoC. SmgGDS is a guanine nucleotide exchange factor that activates RhoA and RhoC in vitro. We previously reported that two splice variants of SmgGDS, SmgGDS-607, and SmgGDS-558, have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb25005cf554ec3aa66bd0640a385581
https://doi.org/10.1158/1541-7786.c.6539238.v1
https://doi.org/10.1158/1541-7786.c.6539238.v1
Autor:
Andrew D. Hauser, Ellen L. Lorimer, Tracy J. Berg, Adam J. Gastonguay, Nathan J. Schuld, Carol L. Williams
Publikováno v:
Cancer Biology & Therapy. 13:647-656
The small GTPase Rac1 regulates many cellular processes, including cytoskeletal reorganization, cell migration, proliferation, and survival. Additionally, Rac1 plays a major role in activating NF-κB-mediated transcription. Both Rac1 and NF-κB regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb10ff2e887dbc08250851a7c578350a
https://doi.org/10.4161/cbt.20082
https://doi.org/10.4161/cbt.20082
Autor:
Andrew D. Hauser, Carol L. Williams, Nathan J. Schuld, Adam J. Gastonguay, Ellen L. Lorimer, Jessica M. Wilson
Publikováno v:
Cell cycle (Georgetown, Tex.). 13(6)
Oncogenic mutation or misregulation of small GTPases in the Ras and Rho families can promote unregulated cell cycle progression in cancer. Post-translational modification by prenylation of these GTPases allows them to signal at the cell membrane. Spl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16ad28511afbe56c1fa908a081707e9
https://pubmed.ncbi.nlm.nih.gov/24552806
https://pubmed.ncbi.nlm.nih.gov/24552806
Autor:
Nathan J. Schuld, Nathan C. Simon, Carol L. Williams, Jeffrey S. Vervacke, Mark D. Distefano, Ellen L. Lorimer, Andrew D. Hauser, Joseph T. Barbieri
Ras family small GTPases localize at the plasma membrane, where they can activate oncogenic signaling pathways. Understanding the mechanisms that promote membrane localization of GTPases will aid development of new therapies to inhibit oncogenic sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70034aae3c8953c18e1c23d9724944c
https://europepmc.org/articles/PMC3945348/
https://europepmc.org/articles/PMC3945348/
Autor:
Carmen Bergom, Jian Huang, Ellen L. Lorimer, Carol L. Williams, Alexander C. Mackinnon, Xiuxu Chen, Andrew D. Hauser, Nathan J. Schuld
Breast cancer malignancy is promoted by the small GTPases RhoA and RhoC. SmgGDS is a guanine nucleotide exchange factor that activates RhoA and RhoC in vitro. We previously reported that two splice variants of SmgGDS, SmgGDS-607, and SmgGDS-558, have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502746803a0b0e902ddeac70847ad118
https://europepmc.org/articles/PMC4285378/
https://europepmc.org/articles/PMC4285378/
Autor:
Andrew D. Hauser, Carol L. Williams, Nathan J. Schuld, Michael B. Dwinell, Patrick Gonyo, Ellen L. Lorimer, Balaraman Kalyanaraman, Donna McAllister, Elizabeth Ntantie, John A. Auchampach
Publikováno v:
Cell Cycle
During metastasis, cancer cells acquire the ability to dissociate from each other and migrate, which is recapitulated in vitro as cell scattering. The small guanosine triphosphatase (GTPase) Rap1 opposes cell scattering by promoting cell-cell adhesio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6342181d9dd05b5d48df35bc6a92e15c
https://doi.org/10.1126/scisignal.2003374
https://doi.org/10.1126/scisignal.2003374
Autor:
Amy L. Funk, Nathan J. Schuld, Christine Hrycnya, Mark D. Distefano, Jeffrey S. Vervacke, Carol L. Williams
Publikováno v:
Peptides Across the Pacific: The Proceedings of the Twenty-Third American and the Sixth International Peptide Symposium.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3efc16c3610c1f38517c12d9aa6f2b6
https://doi.org/10.17952/23aps.2013.208
https://doi.org/10.17952/23aps.2013.208
Autor:
Clifford J. Steer, Julia Nguyen, Kristal A. Newman, Julie V. Vineyard, Carol M. Bruzzone, Gregory M. Vercellotti, Nathan J. Schuld, Chunsheng Chen, John D. Belcher, Joan D. Beckman
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 152(6)
Evaluation of the transfer efficiency of a rat heme oxygenase-1 (HO-1) transgene into mice requires differentiation of rat and mouse HO-1. However, rat and mouse HO-1 have 94% homology; antibodies and enzyme activity cannot adequately distinguish HO-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108eb44ecf466e702b469d9b51fdfa44
https://pubmed.ncbi.nlm.nih.gov/19059164
https://pubmed.ncbi.nlm.nih.gov/19059164