Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Nathan J Cherrington"'
Autor:
Solène Marie, Kayla L. Frost, Raymond K. Hau, Lucy Martinez-Guerrero, Jailyn M. Izu, Cassandra M. Myers, Stephen H. Wright, Nathan J. Cherrington
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 1-28 (2023)
The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes disease-specific alterations to the absorption, distribution, metabolism, and excretion (A
Externí odkaz:
https://doaj.org/article/8844d7a2d73949a28728c4480052e7fb
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 7, Pp 1599-1605 (2022)
Abstract The ongoing pandemic of severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) and subsequently, coronavirus disease 2019 (COVID‐19), has led to the deaths of over 6.1 million people and sparked a greater interest in virology t
Externí odkaz:
https://doaj.org/article/5d645b29a2fb4323abe83a0b549e26aa
Autor:
Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3869-3878 (2021)
Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal drug transporter
Externí odkaz:
https://doaj.org/article/af1ce66f316a49febc4c7e9ade3a64d2
Autor:
Siennah R. Miller, Joseph L. Jilek, Meghan E. McGrath, Raymond K. Hau, Erin Q. Jennings, James J. Galligan, Stephen H. Wright, Nathan J. Cherrington
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children and adolescents. Although the 5‐year survival rate is high, some patients respond poorly to chemotherapy or have recurrence in locations such as the testis. The blood
Externí odkaz:
https://doaj.org/article/a2f0d650e55c4a91b3124a841f865941
Autor:
Patricia A. Vignaux, Thomas R. Lane, Ana C. Puhl, Raymond K. Hau, Stephen H. Wright, Nathan J. Cherrington, Sean Ekins
Publikováno v:
ACS Omega. 8:12532-12537
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f60d79a705e518f4429b8ee8e1c4aa01
https://doi.org/10.1021/acsomega.3c00724
https://doi.org/10.1021/acsomega.3c00724
Autor:
Alesia M Jung, Shawn C Beitel, Shannon L Gutenkunst, Dean Billheimer, Sara A Jahnke, Sally R Littau, Mandie White, Christiane Hoppe-Jones, Nathan J Cherrington, Jefferey L Burgess
Publikováno v:
Toxicological Sciences. 192:223-232
Excretion of toxicants accumulated from firefighter exposures through breastmilk represents a potential hazard. We investigated if firefighting exposures could increase the concentration of polybrominated diphenyl ethers (PBDEs) and aryl hydrocarbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b54b3480b279fdc7b03411676c38a35
https://doi.org/10.1093/toxsci/kfad017
https://doi.org/10.1093/toxsci/kfad017
Publikováno v:
Drug Metabolism and Disposition. 51:560-571
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404059113d15a48760d8e2faac13d14f
https://doi.org/10.1124/dmd.122.001186
https://doi.org/10.1124/dmd.122.001186
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 219 (2022)
Paraquat (PQ) is an agrochemical known to cause pulmonary fibrosis. PQ-induced collagen deposition in the lung is thought to require enzymatic formation of PQ radicals, but the specific enzymes responsible for this bioactivation event in vivo have no
Externí odkaz:
https://doaj.org/article/59d02f316c6647e8a2658e63c378bdc3
Autor:
Ai-Ming Yu, Magnus Ingelman-Sundberg, Nathan J. Cherrington, Lauren M. Aleksunes, Ulrich M. Zanger, Wen Xie, Hyunyoung Jeong, Edward M. Morgan, Peter J. Turnbaugh, Curtis D. Klaassen, Aadra P. Bhatt, Matthew R. Redinbo, Pengying Hao, David J. Waxman, Li Wang, Xiao-bo Zhong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 7, Iss 2, Pp 241-248 (2017)
Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21st International Symposium on Microsomes and Drug Oxidations held in Davis,
Externí odkaz:
https://doaj.org/article/2f3f00db456d41a9b0dff3480539d4d3
Autor:
Kayla L Frost, Joseph L Jilek, Austin D Thompson, Robert R Klein, Shripad Sinari, Elmira Torabzedehkorasani, Dean D Billheimer, Rick G Schnellmann, Nathan J Cherrington
Publikováno v:
Toxicol Sci
Inflammatory liver diseases, including nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (ALD), hepatitis C virus (HCV), and ALD/HCV, account for nearly 2 million deaths annually. Despite increasing evidence that liver dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74113f6fce35f087ee353acd0c21e1e
https://doi.org/10.1093/toxsci/kfac070
https://doi.org/10.1093/toxsci/kfac070