Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Nathan J Bowen"'
1
Akademický článek
Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach.
Autor: Shubin W Shahab, Lilya V Matyunina, Roman Mezencev, L DeEtte Walker, Nathan J Bowen, Benedict B Benigno, John F McDonald
Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22508 (2011)
MicroRNAs (miRNAs) are short (∼22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. Previous studies have shown that miRNAs inhibit the translation and facilitate the degr
Externí odkaz: https://doaj.org/article/b68aae28e5354e80b6533ef8e46bfd42
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2
Akademický článek
Prediction of transposable element derived enhancers using chromatin modification profiles.
Autor: Ahsan Huda, Eishita Tyagi, Leonardo Mariño-Ramírez, Nathan J Bowen, Daudi Jjingo, I King Jordan
Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27513 (2011)
Experimentally characterized enhancer regions have previously been shown to display specific patterns of enrichment for several different histone modifications. We modelled these enhancer chromatin profiles in the human genome and used them to guide
Externí odkaz: https://doaj.org/article/147dc18a8fff4fecb434fe18fa2d5b50
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3
Akademický článek
Ovarian carcinoma subtypes are different diseases: implications for biomarker studies.
Autor: Martin Köbel, Steve E Kalloger, Niki Boyd, Steven McKinney, Erika Mehl, Chana Palmer, Samuel Leung, Nathan J Bowen, Diana N Ionescu, Ashish Rajput, Leah M Prentice, Dianne Miller, Jennifer Santos, Kenneth Swenerton, C Blake Gilks, David Huntsman
Publikováno v: PLoS Medicine, Vol 5, Iss 12, p e232 (2008)
BACKGROUND: Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural histories, most ovarian carcinoma biomarker studies and current treatment protoco
Externí odkaz: https://doaj.org/article/b5d9b37051e44d1f81deae27f85c155a
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4
Akademický článek
Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas.
Autor: Carlos S Moreno, Lilya Matyunina, Erin B Dickerson, Nina Schubert, Nathan J Bowen, Sanjay Logani, Benedict B Benigno, John F McDonald
Publikováno v: PLoS ONE, Vol 2, Iss 5, p e441 (2007)
Gene expression profiles of malignant tumors surgically removed from ovarian cancer patients pre-treated with chemotherapy (neo-adjuvant) prior to surgery group into two distinct clusters. One group clusters with carcinomas from patients not pre-trea
Externí odkaz: https://doaj.org/article/4addfdca0fe54f898a25e9cd97a6726a
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5
Akademický článek
Bromocriptine monotherapy overcomes prostate cancer chemoresistance in preclinical models
Autor: Lijuan Bai, Xin Li, Yang Yang, Rui Zhao, Elshaddai Z. White, Alira Danaher, Nathan J. Bowen, Cimona V. Hinton, Nicholas Cook, Dehong Li, Alyssa Y. Wu, Min Qui, Yuhong Du, Haian Fu, Omer Kucuk, Daqing Wu
Publikováno v: Translational Oncology, Vol 34, Iss , Pp 101707- (2023)
Chemoresistance is a major obstacle in the clinical management of metastatic, castration-resistant prostate cancer (PCa). It is imperative to develop novel strategies to overcome chemoresistance and improve clinical outcomes in patients who have fail
Externí odkaz: https://doaj.org/article/84a2284d1e024c788c4eb028b30b0e80
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6
Abstract C023: Aryl hydrocarbon receptor and leptin promote prostate cancer progression and may be associated with chemoresistance
Autor: Kofi K. Khamit-Kush, Joann B. Powell, Jeffrey A. Handy, Nathan J. Bowen, Valerie Odero-Marah, Daqing Wu
Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 32:C023-C023
The aryl hydrocarbon receptor (AhR) is a nuclear transcription factor and xenobiotic sensor reported to mediate diet-induced obesity and is upregulated in high-grade prostate cancer (PCa). Previously published data from our lab shows AhR protein is o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b23c62b669fe7b3a427cca500ad4c41
https://doi.org/10.1158/1538-7755.disp22-c023
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7
The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate
Autor: Isha Saini, Shravan Kumar Komaragiri, Jaideep Chaudhary, Dhanushka Hewa Bostanthirige, Majid Al-Zahrani, Jugal Joshi, Sanjay R. Jain, Matthew C. Havrda, Nathan J. Bowen
Publikováno v: Oncoscience
Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. In this study we investigated the effect of loss of Id4 (Id4-/-) on mouse prostate devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1edf4fbaf91baec5e2c709850da51f
https://pubmed.ncbi.nlm.nih.gov/33884281
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10
Highly and moderately aggressive mouse ovarian cancer cell lines exhibit differential gene expression
Autor: Leticia B McDaniels, Elena Skripnikova, Ian R. Davenport, Qian-Jin Zhang, Yong-Yu Liu, Fengkun Du, Yan Li, Paula Polk, Shubha P. Kale, Wensheng Zhang, Xiao-Lin Li, Harris E. McFerrin, Guangdi Wang, Yuan-Xiang Meng, Nathan J. Bowen
Publikováno v: Tumor Biology. 37:11147-11162
Patients with advanced epithelial ovarian cancer often experience disease recurrence after standard therapies, a critical factor in determining their five-year survival rate. Recent reports indicated that long-term or short-term survival is associate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e5eae8921541219b808577d43f4916
https://doi.org/10.1007/s13277-015-4518-4
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