Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Nathan I. Nicely"'
Autor:
Qifeng Han, Julia A. Jones, Nathan I. Nicely, Rachel K. Reed, Xiaoying Shen, Katayoun Mansouri, Mark Louder, Ashley M. Trama, S. Munir Alam, Robert J. Edwards, Mattia Bonsignori, Georgia D. Tomaras, Bette Korber, David C. Montefiori, John R. Mascola, Michael S. Seaman, Barton F. Haynes, Kevin O. Saunders
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Here, the authors report that specific monoclonal antibodies isolated from vaccinated rhesus macaques can neutralize a subset of Tier 2 difficult-to-neutralize HIV-1 that express Env in an open conformation, suggesting that V3 loop-specific targeting
Externí odkaz:
https://doaj.org/article/0ac5be9185814e708e45b16386f135cf
Autor:
David R. Martinez, Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, Juilin Chen, Michael Mengual, Ayooluwa O. Douglas, Holly Heimsath, Kevin O. Saunders, Nathan I. Nicely, Joshua Eudailey, Giovanna Hernandez, Papa Kwadwo Morgan-Asiedu, Kevin Wiehe, Barton F. Haynes, M. Anthony Moody, Celia LaBranche, David C. Montefiori, Feng Gao, Sallie R. Permar
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 matern
Externí odkaz:
https://doaj.org/article/547a9acf953c4c8cac9d486936a9784c
Autor:
Quang N. Nguyen, David R. Martinez, Jonathon E. Himes, R. Whitney Edwards, Qifeng Han, Amit Kumar, Riley Mangan, Nathan I. Nicely, Guanhua Xie, Nathan Vandergrift, Xiaoying Shen, Justin Pollara, Sallie R. Permar
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background The initial envelope (Env)-specific antibody response in acutely HIV-1-infected individuals and simian immunodeficiency virus (SIV)-infected rhesus monkeys (RMs) is dominated by non-neutralizing antibodies targeting Env gp41. In c
Externí odkaz:
https://doaj.org/article/fe415d75a5274bc3b545c519abd0e1d7
Autor:
Wilton B. Williams, Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M. Anthony Moody, Hua-Xin Liao, S. Munir Alam, Thomas B. Kepler, Akshaya Ramesh, Kevin Wiehe, James A. Holland, Todd Bradley, Nathan Vandergrift, Kevin O. Saunders, Robert Parks, Andrew Foulger, Shi-Mao Xia, Mattia Bonsignori, David C. Montefiori, Mark Louder, Amanda Eaton, Sampa Santra, Richard Scearce, Laura Sutherland, Amanda Newman, Hilary Bouton-Verville, Cindy Bowman, Howard Bomze, Feng Gao, Dawn J. Marshall, John F. Whitesides, Xiaoyan Nie, Garnett Kelsoe, Steven G. Reed, Christopher B. Fox, Kim Clary, Marguerite Koutsoukos, David Franco, John R. Mascola, Stephen C. Harrison, Barton F. Haynes, Laurent Verkoczy
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnA
Externí odkaz:
https://doaj.org/article/69f91741f8e94cd5827c2664a8377d65
Autor:
Kevin O. Saunders, Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R. Ryan Meyerhoff, Robert Parks, William E. Walkowicz, Baptiste Aussedat, Nelson R. Wu, Fangping Cai, Yusuf Vohra, Peter K. Park, Amanda Eaton, Eden P. Go, Laura L. Sutherland, Richard M. Scearce, Dan H. Barouch, Ruijun Zhang, Tarra Von Holle, R. Glenn Overman, Kara Anasti, Rogier W. Sanders, M. Anthony Moody, Thomas B. Kepler, Bette Korber, Heather Desaire, Sampa Santra, Norman L. Letvin, Gary J. Nabel, David C. Montefiori, Georgia D. Tomaras, Hua-Xin Liao, S. Munir Alam, Samuel J. Danishefsky, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2175-2188 (2017)
Summary: Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antib
Externí odkaz:
https://doaj.org/article/f020d40e9877461f93e8d9d15c7fa9e4
Autor:
Nathan I. Nicely, Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S. Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Merlin L. Robb, Robert J. O'Connell, Nelson L. Michael, Jerome H. Kim, Hua-Xin Liao, S. Munir Alam, Kwan-Ki Hwang, Mattia Bonsignori, Barton F. Haynes
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 713-722 (2015)
Human monoclonal antibody CH58 isolated from an RV144 vaccinee binds at Lys169 of the HIV-1 Env gp120 V2 region, a site of vaccine-induced immune pressure. CH58 neutralizes HIV-1 CRF_01 AE strain 92TH023 and mediates ADCC against CD4+ T cell targets
Externí odkaz:
https://doaj.org/article/fe0db6cc98794aed82f29ecfaf2f89e5
Autor:
E. Keats Shwab, Praveen R. Juvvadi, Greg Waitt, Erik J. Soderblom, M. Arthur Moseley, Nathan I. Nicely, Yohannes G. Asfaw, William J. Steinbach
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT Invasive aspergillosis (IA), caused by the filamentous fungal pathogen Aspergillus fumigatus, is a major cause of death among immunocompromised patients. The cyclic AMP/protein kinase A (PKA) signaling pathway is essential for hyphal growth
Externí odkaz:
https://doaj.org/article/140506a1f19b4a60a82b864e85bf4afe
Autor:
Claire Soave, Charles Ducker, Naeyma Islam, Seongho Kim, Sally Yurgelevic, Nathan I. Nicely, Luke Pardy, Yanfang Huang, Peter E. Shaw, Gregory Auner, Alex Dickson, Manohar Ratnam
Publikováno v:
Molecular Pharmacology. 103:211-220
Autor:
Tierra A. Bobo, Preston N. Samowitz, Michael I. Robinson, Laura I. Montes, Lawrence J. Forsberg, Richard Feng, Nathan I. Nicely, Haiyan Fu
Publikováno v:
Gene Therapy. 30:377-385
Autor:
Elizaveta T. Wick, Colton J. Treadway, Zhijun Li, Nathan I. Nicely, Zhizhong Ren, Albert S. Baldwin, Yue Xiong, Joseph S. Harrison, Nicholas G. Brown
Publikováno v:
J Virol
Viruses evolve mechanisms to exploit cellular pathways that increase viral fitness, e.g., enhance viral replication or evade the host cell immune response. The ubiquitin-proteosome system, a fundamental pathway-regulating protein fate in eukaryotes,